Results 61 to 70 of about 13,136,107 (398)

The Emerging Role of Urease as a General Microbial Virulence Factor

PLoS Pathogens, 2014
Urea is generated in humans following the breakdown of amino acids and is evenly distributed throughout the body, including in the central nervous system, subcutaneous adipose tissue, blood serum, and epithelial lining fluid [1], [2].
Julian C Rutherford
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection

Frontiers in Cellular and Infection Microbiology, 2020
Toxoplasma gondii is an exceptionally successful parasite that infects a very broad host range, including humans, across the globe. The outcome of infection differs remarkably between hosts, ranging from acute death to sterile infection.
Debanjan Mukhopadhyay, David Arranz-Solís, Jeroen P. J. Saeij   +2 more
doaj   +1 more source

High sporulation and overexpression of virulence factors in biofilms and reduced susceptibility to vancomycin and linezolid in recurrent Clostridium [Clostridioides] difficile infection isolates [PDF]

, 2019
Clostridium [Clostridioides] difficile infection (CDI) is one of the leading causes of diarrhea associated with medical care worldwide, and up to 60% of patients with CDI can develop a recurrent infection (R-CDI). A multi-species microbiota biofilm model
Baines, Simon, Camacho-Ortiz, Adrian, Flores-Trevino, Samantha, Garza-Gonzalez, Elvira, Maldonado-Garza, Hector Jesus, Morfin-Otero, Rayo, Rodriguez-Noriega, Eduardo, Rodrıguez-Noriega, Eduardo, Tijerina-Rodrıguez, Laura, Villarreal-Trevino, Licet   +9 more
core   +2 more sources

Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility

Physiological Reviews, 2020
Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, COPD, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons.
H. Ji, Runzhen Zhao, S. Matalon, M. Matthay   +3 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Nicotinamide Adenine Dinucleotide-Dependent Flavin Oxidoreductase of Mycoplasma hyopneumoniae Functions as a Potential Novel Virulence Factor and Not Only as a Metabolic Enzyme

Frontiers in Microbiology, 2021
Mycoplasma hyopneumoniae (Mhp) is the main pathogen that causes enzootic pneumonia, a disease that has a significant impact on the pig industry worldwide. The pathogenesis of enzootic pneumonia, especially possible virulence factors of Mhp, has still not
Xing Xie, Fei Hao, Rong Chen, Jingjing Wang, Yanna Wei, Jin Liu, Haiyan Wang, Zhenzhen Zhang, Yun Bai, Guoqing Shao, Qiyan Xiong, Zhixin Feng   +11 more
doaj   +1 more source

Virulence profile comparison between LEE-negative Shiga toxin-producing Escherichia coli (STEC) strains isolated from cattle and humans [PDF]

, 2010
For comparison purposes, the prevalence of 8 virulence markers was investigated, by PCR, in 153 cattle and 47 human Locus for Enterocyte Effacement (LEE)-negative Shiga toxin-producing Escherichia coli (STEC) strains isolated in Argentina.
Galli, Lucía, Irino, Kinue, Leotta, Gerardo Anibal, Miliwebsky, Elizabeth, Rivas, Marta   +4 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Pan-genomic analysis of Corynebacterium amycolatum gives insights into molecular mechanisms underpinning the transition to a pathogenic phenotype

Frontiers in Microbiology, 2022
Corynebacterium amycolatum is a nonlipophilic coryneform which is increasingly being recognized as a relevant human and animal pathogen showing multidrug resistance to commonly used antibiotics.
Hendor N. R. Jesus, Danilo J. P. G. Rocha, Rommel T. J. Ramos, Artur Silva, Bertram Brenig, Aristóteles Góes-Neto, Mateus M. Costa, Siomar C. Soares, Vasco Azevedo, Eric R. G. R. Aguiar, Luiz Martínez-Martínez, Luiz Martínez-Martínez, Luiz Martínez-Martínez, Alain Ocampo, Alain Ocampo, Sana Alibi, Alexis Dorta, Alexis Dorta, Luis G. C. Pacheco, Luis G. C. Pacheco, Jesus Navas, Jesus Navas   +21 more
doaj   +1 more source