Results 51 to 60 of about 4,443,372 (306)

Autonomous virulence adaptation improves coevolutionary optimization [PDF]

, 2011
A novel approach for the autonomous virulence adaptation (AVA) of competing populations in a coevolutionary optimization framework is presented.
Ait-Boudaoud, D, Ait-Boudaoud, Djamel, John Cartlidge, Djamel Ait-Boudaoud, Cartlidge, J., Cartlidge, J   +5 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Analyzing the distribution of virulence factors of Mycobacterium tuberculosis and the impact of virulence gene mutations on treatment outcomes in different lineages using whole-genome sequencing in Urumqi

Virulence
This study centers on Urumqi, utilizing whole-genome sequencing and comparative genomics, we explored virulence factor mutations in different Mycobacterium tuberculosis lineages and their impact on tuberculosis patient prognosis.
Jiandong Yang, Yaoqin Lu, Yanggui Chen, Yida Wang, Chao Wang, Kai Wang   +5 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The ability to utilize mucin affects the regulation of virulence gene expression in Streptococcus pneumoniae.

, 2008
Streptococcus pneumoniae colonizes the mucin-rich environment of the nasopharynx. As colonization may be the first stage of infection, investigation was carried out as to whether the pneumococcus could utilize mucin as a source of nutrient and whether ...
Manco, Sonia, Kadioglu, Aras, Andrew, Peter W, Yesilkaya, Hasan, Terra, Vanessa S   +4 more
core   +1 more source

The coevolution of virulence : tolerance in perspective [PDF]

, 2010
Coevolutionary interactions, such as those between host and parasite, predator and prey, or plant and pollinator, evolve subject to the genes of both interactors.
Colegrave, Nick, Colegrave Nick, Tom J. Little, David M Shuker, Day, Troy, Tom J Little, Graham Andrea L., Nick Colegrave, Little, Tom J., Troy Day, Shuker David M., Graham, Andrea L., Andrea L. Graham, Little Tom J., David M. Shuker, Day Troy, Shuker, David M., Andrea L Graham   +17 more
core   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Protein Disulfide Isomerase FgEps1 Is a Secreted Virulence Factor in Fusarium graminearum

Journal of Fungi, 2023
Protein disulfide isomerase (PDI) is a member of the thioredoxin (Trx) superfamily with important functions in cellular stability, ion uptake, and cellular differentiation.
Kouhan Liu, Xintong Wang, Ying Li, Yifeng Shi, Yanyan Ren, Aolin Wang, Bingjie Zhao, Peng Cheng, Baotong Wang   +8 more
doaj   +1 more source

Virulence factors of Helicobacter pylori

International Journal of Medical Microbiology, 2001
To date a number of virulence factors have been identified and characterised from the gastric pathogen Helicobacter pylori. The vacuolating toxin (VacA) is a major determinant of H. pylori-associated gastric disease. In non-polarised cells, VacA alters the endocytic pathway, resulting in the release of acid hydrolases and the reduction of both ...
DUNDON, WILLIAM GEORGE, DE BERNARD, MARINA, MONTECUCCO, CESARE   +2 more
openaire   +3 more sources

Gac two-component system in Pseudomonas syringae pv. tabaci is required for virulence but not for hypersensitive reaction [PDF]

, 2008
Pseudomonas syringae pv. tabaci 6605 causes wildfire disease on host tobacco plants. To investigate the regulatory mechanism of the expression of virulence, Gac two-Component system-defective mutants, Delta gacA and Delta gacS, and a double mutant, Delta
Ichinose, Yuki, Marutani, Mizuri, Ogawa, Yujiro, Yoshishige, Inagaki, Toyoda, Kazuhiro, Shiraishi, Tomonori, Taguchi, Fumiko, Hossain, Mijan Md.   +7 more
core   +1 more source