Results 141 to 150 of about 13,031,687 (355)
What a Difference a Dalton Makes: Bacterial Virulence Factors Modulate Eukaryotic Host Cell Signaling Systems via Deamidation [PDF]
, 2013 E. Washington +2 more
openalex +1 more source
Advanced Science, EarlyView.This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song +14 more
wiley +1 more source
Angewandte Chemie, EarlyView.A total of 16 chemically synthesized capsular polysaccharide (CPS) fragments related to Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii were analyzed by glycan microarray. Comparative screening revealed three conserved epitopes that act as cross‐protective vaccine lead candidates against multidrug‐resistant (MDR) bacterial ...
Amar Kumar Mishra +9 more
wiley +2 more sources
Advanced Science, EarlyView.To address the infection‐associated orthopedic implant failures, this study presents a gelatinase‐responsive antibacterial titanium implant (Ti‐Dual) featuring a dual‐anchored fusion peptide containing antibacterial (HHC36) and osteogenic (RGD) domains connected by a cleavable GPLGV linker.
Ru Zhong +5 more
wiley +1 more source
Advanced Science, EarlyView.Solution structures of a series of cyclic lipodepsipeptides from Pseudomonas reveal that these specialized metabolites adopt left‐handed alpha helical conformations of only two types, being either ‘stapled’ or ‘catch‐pole’ helix. The particular modular distribution of the biosynthetic gene clusters is found to determine the extent of their conserved ...
Benjámin Kovács +9 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.A point‐of‐care testing method based on solvent‐responsive magnetic beads suitable for large‐area diagnosis and mutation screening in remote areas was developed to detect it by combining bioluminescenct pyrophosphate in real‐time technology and recombinase‐aid amplification technology.
Zhongjie Fei +8 more
wiley +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson +8 more
wiley +1 more source
Bacterial virulence factors differentially activate the innate immune system in the lung [PDF]
, 2008 Christian Bode +4 more
openalex +1 more source