Epidemiology, Virulence Factors, and Antibacterial Resistance of <i>Klebsiella</i> spp.: The Known Unknowns. [PDF]
Krūmiņa A +4 more
europepmc +1 more source
Antibiotic Remodeling of the Gut Microbiota Impairs Host Resistance to Secondary Infection
Gut microbial dynamics induced by four antibiotics, revealed distinct taxonomic and functional shifts. Vancomycin‐perturbed bacteriomes were proven to promote pathogen resistance to antibiotic treatment. Metronidazole‐treated mice showed pronounced Salmonella translocation to hepatic tissue, and altered Enterococcus avium populations modulated host ...
Miaoyu Li +17 more
wiley +1 more source
Virulence factors of <i>Phocoenobacter atlanticus</i> subspecies <i>atlanticus</i>: in search of vaccine targets. [PDF]
Ellul RM +6 more
europepmc +1 more source
This study employed multi‐omics approaches to investigate the regulatory mechanism of Mycobacterium PknG on host cell processes. We found that host lysine‐tRNA ligase (KARS) is a potential substrate of PknG; and PknG can regulate the immune response by catalyzing the phosphorylation of KARS at T592 and T595 sites, affecting the phosphorylation level in
Nana Tian +13 more
wiley +1 more source
<i>Aggregatibacter actinomycetemcomitans</i> virulence factors and systemic inflammation: linking periodontitis to rheumatoid arthritis. [PDF]
Seguel-Fuentes E +6 more
europepmc +1 more source
BacSafe: A Comprehensive Database for Integrated Assessment of Bacterial Biosafety
The substantial threats that bacterial contamination poses to healthcare and industrial production requires a comprehensive assessment of biosafety risks for each bacterial species. Here, we introduce BacSafe, a novel database that integrates diverse domains of biosafety knowledge and evaluates bacterial risk across both clinical and environmental ...
Ye Feng +9 more
wiley +1 more source
Quantitative proteomics of infected macrophages reveals novel Leishmania virulence factors. [PDF]
Hagedorn N +6 more
europepmc +1 more source
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory condition. Dysbiosis is commonly observed. This study identified distinct sinonasal microbial communities in CRSwNP patients and explored their clinical and pathological associations. Two distinct microbial communities were identified: community type 1 (CT1), dominated by
Bixing Fang +10 more
wiley +1 more source
EhVps29 Has a Role in the Location of the Retromer Complex and the Function of Key Virulence Factors in <i>Entamoeba histolytica</i>. [PDF]
Martínez-Valencia D +6 more
europepmc +1 more source
The “efficacy paradox” of phytochemicals, low bioavailability yet significant health benefits, is associated with gut microbiota, which biotransforms dietary precursors into bioactive metabolites, enabling systemic effects. Thus, health outcomes of diet depend not just on intake “the rainbow”, but on gut microbial metabolism, redefining “you are what ...
Peng Yang, Ren‐You Gan
wiley +1 more source

