Results 111 to 120 of about 268,142 (318)

'Yersinia pseudotuberculosis' mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1

, 2010
Manganese has an important yet undefined role in the virulence of many bacterial pathogens. In this study we confirm that a null mutation in Yersinia pseudotuberculosis mntH reduces intracellular manganese accumulation.
Richard W. Titball, Oyston, Petra C. F., Ford, Donna C., Champion, Olivia L., Olivia L. Champion, Andrey Karlyshev, Donna C. Ford, Petra C. F. Oyston, Titball, Richard W., Titball, Richard W, Karlyshev, Andrey, Wren, Brendan W, Champion, Olivia L, Duffield, Melanie, Ian A. M. Cooper, Ford, Donna C, Wren, Brendan W., Oyston, Petra CF, Brendan W. Wren, Cooper, Ian AM, Cooper, A. M., Melanie Duffield   +21 more
core   +1 more source

The coevolution of virulence : tolerance in perspective [PDF]

, 2010
Coevolutionary interactions, such as those between host and parasite, predator and prey, or plant and pollinator, evolve subject to the genes of both interactors.
Colegrave, Nick, Colegrave Nick, Tom J. Little, David M Shuker, Day, Troy, Tom J Little, Graham Andrea L., Nick Colegrave, Little, Tom J., Troy Day, Shuker David M., Graham, Andrea L., Andrea L. Graham, Little Tom J., David M. Shuker, Day Troy, Shuker, David M., Andrea L Graham   +17 more
core   +1 more source

A Virus‐Inducible E3–RLCK–MADS Module Coordinates Suppression of Plant Immunity and Fertility in Rice

Advanced Science, EarlyView.
ABSTRACT Viruses often hijack host developmental programs to promote infection, but the mechanistic links between reproductive regulation and antiviral immunity remain incompletely understood. Here, we identify a virus‐triggered hierarchical degradation cascade that links antiviral immunity and fertility regulation in rice. We show that the rice grassy
Yuansheng Wu, Fengling Wu, Shiting Huang, Denglu Yang, Xin Lei, Xue Zhang, Na Liu, Peng Gan, Chuan Li, Jie Zhang, Ming Wu, Qingxiao Jia, Shanshan Zhao, Jianguo Wu   +13 more
wiley   +1 more source

Difference in virulence between Staphylococcus aureus isolates causing gangrenous mastitis versus subclinical mastitis in a dairy sheep flock

, 2009
Staphylococcus aureus mastitis in dairy sheep ranges from subclinical mastitis to lethal gangrenous mastitis. Neither the S. aureus virulence factors nor the host-factors or the epidemiological events contributing to the different outcomes are known.
Le Loir, Y, Robinson, DA, Caroline Le Marechal, Vautor, Eric, Le Loir, Yves, Lindsay, Jodi, Le Marechal, C, Lindsay, J, Joshua Cockfield, D. Ashley Robinson, Chevalier, M, Le Marechal, Caroline, Jodi Lindsay, Chevalier, Marlène, Vautor, E, Richard Thiery, Eric Vautor, Thiery, R, Cockfield, J, Cockfield, Joshua, Yves Le Loir, Marlène Chevalier, Robinson, D., Thiery, Richard   +23 more
core   +1 more source

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

A Genome-Wide Association Study Identifies Genomic Regions for Virulence in the Non-Model Organism Heterobasidion annosum ss [PDF]

, 2013
The dense single nucleotide polymorphisms (SNP) panels needed for genome wide association (GWA) studies have hitherto been expensive to establish and use on non-model organisms.
Brandström Durling, Mikael, Mikael Brandström-Durling, Stenlid, Jan,, Olson, Åke,, Sveriges lantbruksuniversitet., Jan Stenlid (102750), Kerstin Dalman (102738), Himmelstrand, Kajsa,, Himmelstrand, Kajsa, Mårten Lind (102744), Kerstin Dalman, Mårten Lind, Olson, Åke, Lind, Mårten,, Kajsa Himmelstrand (102739), Jan Stenlid, Åke Olson (102741), Stenlid, Jan, Lind, Mårten, Mikael Brandström-Durling (102747), Dalman, Kerstin,, Brandström Durling, Mikael,, Åke Olson, Kajsa Himmelstrand, Dalman, Kerstin   +24 more
core   +1 more source

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Characterisation of the effects of salicylidene acylhydrazide compounds on type three secretion in Escherichia coli O157:H7 [PDF]

, 2009
Recent work has highlighted a number of compounds that target bacterial virulence by affecting gene regulation. In this work, we show that small-molecule inhibitors affect the expression of the type III secretion system (T3SS) of <i>Escherichia ...
Layton, Abigail, Stevens, M. P., Tree, J.J., Stevens, Mark P, Tree, J. J., Roe, A. J., McInally, C., Roe, Andrew J, Tree, Jai J, Wang, Dai, Elofsson, M., Houghton, I., Mahajan, A., Stevens, M.P., Gally, D. L., Roe, A.J., Wang, D., Gally, D.L., Layton, A., Elofsson, Mikael,, McInally, Carol, Houghton, Irene, Mahajan, Arvind, Gally, David L   +23 more
core   +1 more source

H2S‐Amplified “Three‐in‐One” Antibacterial Strategy for Periodontitis Treatment Using a Photosensitive Pillararene‐Embedded COF/MOF Hybrid

Advanced Science, EarlyView.
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang, Meng‐Hao Li, Liang Cheng, Tian‐Shou Zhang, Hui Hui, Yan Wang, Hong‐Pu Zhang, Bo‐Wen Liu, Lin Wang, Ying‐Wei Yang   +9 more
wiley   +1 more source