Results 111 to 120 of about 2,134,385 (307)

Distribution of virulence and quorum sensing genes.

, 2023
Distribution of virulence and quorum sensing genes.
Mayada Gwida (3908152), Chukwunonso N. Amolo (14564239), Anthony I. Okoh (5618081), Abeni Beshiru (5775296), Isoken H. Igbinosa (5775299), Abraham G. Ogofure (10938708), Maged El-Ashker (730451), Etinosa O. Igbinosa (5775302), Olajide Akinnibosun (14564242)   +8 more
core   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

Occurrence of virulence genes in multidrug-resistant Escherichia coli isolates from humans, animals, and the environment: One health perspective.

PLoS ONE
Escherichia coli is one of the critical One Health pathogens due to its vast array of virulence and antimicrobial resistance genes. This study used multiplex PCR to determine the occurrence of virulence genes bfp, ompA, traT, eaeA, and stx1 among 50 ...
Edwin M James, Zuhura I Kimera, Fauster X Mgaya, Elieshiupendo M Niccodem, Joely Ezekiely Efraim, Mecky I Matee, Erasto V Mbugi   +6 more
doaj   +1 more source

Heatmap of virulence genes.

, 2012
Heatmap of virulence genes.
Anne-Laure Vivant (135124), Dominique Garmyn (135112), Laurent Gal (135120), Yoann Augagneur (135116), Pascal Piveteau (135127)   +4 more
core   +1 more source

Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux. [PDF]

, 2008
BACKGROUND: Human and animal health is constantly under threat by emerging pathogens that have recently acquired genetic determinants that enhance their survival, transmissibility and virulence.
Hinds, Jason, Richard W Titball, Wren, Brendan W, Dawson, LF, Titball Richard W, Dawson Lisa F, Lisa F Dawson, Richard A Stabler, Oyston, Petra CF, Titball, RW, Stabler, Richard A, Dawson, Lisa F, Hinds Jason, Oyston, PCF, Stabler Richard A, Wren, BW, Witney, AA, Petra CF Oyston, Titball, Richard W, Oyston Petra CF, Witney, Adam A, Jim Wade, Witney Adam A, Hinds, J, Wren Brendan W, Wade, Jim, Jason Hinds, Wade, J, Stabler, RA, Oyston, PC, Adam A Witney, Wade Jim, Brendan W Wren   +32 more
core   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source

Chemical Inhibition of Pyocyanin Biosynthesis Attenuates Virulence of Pseudomonas aeruginosa

Angewandte Chemie, EarlyView.
Anti‐virulence strategies disarm pathogens rather than killing them directly. A β‐lactone reduces pyocyanin production without affecting growth. Chemical proteomics identified PqsC as the primary target via binding to Cys129. Crystallography revealed the binding mode, and SAR yielded a chloroacetamide inhibitor with improved enzymatic potency and anti ...
Wei Ding, Sebastian R. Borgert, Wulf Blankenfeldt, Stephan A. Sieber   +3 more
wiley   +2 more sources

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources