Results 91 to 100 of about 268,142 (318)

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Cholera virulence gene expression [PDF]

Genome Biology, 2000
Expression patterns of Vibrio cholerae virulence genes determined during an infection differ dramatically from those observed in conventional in vitro analyses.
openaire   +1 more source

The Viral Replication Complex Is Associated with the Virulence of Newcastle Disease Virus

, 2010
Virulent strains of Newcastle disease virus ([NDV] also known as avian paramyxovirus type 1) can be discriminated from low-virulence strains by the presence of multiple basic amino acid residues at the proteolytic cleavage site of the fusion (F) protein.
Peeters, B.P.H., G. Koch, B. P. H. Peeters, Rottier, P.J.M., Dortmans, J.C.F.M., J. C. F. M. Dortmans, P. J. M. Rottier, Koch, G.   +7 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Pyruvate formate lyase is required for pneumococcal fermentative metabolism and virulence.

, 2009
Knowledge of the in vivo physiology and metabolism of Streptococcus pneumoniae is limited, even though pneumococci rely on efficient acquisition and metabolism of the host nutrients for growth and survival.
Andrew, Peter W., Homer, Karen A, Spissu, Francesca, Homer, Karen A., Benisty, Rachel, Porat, Nurith, Neves, Ana R., Andrew, Peter W, Yesilkaya, Hasan, Neves, Ana R, Terra, Vanessa S., Carvalho, Sandra M, Terra, Vanessa S, Carvalho, Sandra M.   +13 more
core   +1 more source

Self‐Amplifying Redox Cycle Triggers Ferroptosis/Cuproptosis Synergy for Enhanced Bacterial Eradication

Advanced Science, EarlyView.
This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao, Shaolong Qiu, Jiangli Cao, Jifeng Liu, Zhiyong Song, Ting Du, Xinjun Du   +6 more
wiley   +1 more source

Distribution of Virulence Factors in Vancomycin-Resistant Enterococci Isolated from Clinical and Intestinal Samples

Microorganisms
Virulence factors in enterococci play an important role in the pathogenesis of enterococcal infection and colonization. The aim was to determine the prevalence of genes encoding virulence factors in VRE from clinical and intestinal samples.
Preslava Mihaylova Hristova
doaj   +1 more source

Newly Emerging MDR B. cereus in Mugil seheli as the First Report Commonly Harbor nhe, hbl, cytK, and pc-plc Virulence Genes and bla1, bla2, tetA, and ermA Resistance Genes

Infection and Drug Resistance, 2022
Abdelazeem M Algammal,1 Khyreyah J Alfifi,2 Mahmoud Mabrok,3 Marfat Alatawy,2 Dalia A Abdel-moneam,4 Saad Alghamdi,5 Marwa M Azab,6 Reham A Ibrahim,7 Helal F Hetta,8 Reham M El-Tarabili1 1Department of Bacteriology, Immunology, and Mycology, Faculty of ...
Algammal AM, Alfifi KJ, Mabrok M, Alatawy M, Abdel-moneam DA, Alghamdi S, Azab MM, Ibrahim RA, Hetta HF, El-Tarabili RM   +9 more
doaj  

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Correlation between antimicrobial resistance and virulence in carbapenem-resistant Klebsiella pneumoniae at colonization and infection stages

BMC Infectious Diseases
Objective Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a critical global public health. To investigate the dynamic changes of drug resistance genes and virulence traits in carbapenem-resistant Klebsiella pneumoniae during colonization-
Junning He, Yijie Yin, Cheng Li, Ning Xie, Peilin Zhang, Guixia Wang, Xianting Liang, Yongfang Liu   +7 more
doaj   +1 more source