Results 81 to 90 of about 1,788,404 (210)

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Newly Emerging MDR B. cereus in Mugil seheli as the First Report Commonly Harbor nhe, hbl, cytK, and pc-plc Virulence Genes and bla1, bla2, tetA, and ermA Resistance Genes

Infection and Drug Resistance, 2022
Abdelazeem M Algammal,1 Khyreyah J Alfifi,2 Mahmoud Mabrok,3 Marfat Alatawy,2 Dalia A Abdel-moneam,4 Saad Alghamdi,5 Marwa M Azab,6 Reham A Ibrahim,7 Helal F Hetta,8 Reham M El-Tarabili1 1Department of Bacteriology, Immunology, and Mycology, Faculty of ...
Algammal AM, Alfifi KJ, Mabrok M, Alatawy M, Abdel-moneam DA, Alghamdi S, Azab MM, Ibrahim RA, Hetta HF, El-Tarabili RM   +9 more
doaj  

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

A Genome-Wide Association Study Identifies Genomic Regions for Virulence in the Non-Model Organism Heterobasidion annosum ss [PDF]

, 2013
The dense single nucleotide polymorphisms (SNP) panels needed for genome wide association (GWA) studies have hitherto been expensive to establish and use on non-model organisms.
Olson, Åke, Brandström Durling, Mikael, Himmelstrand, Kajsa, Dalman, Kerstin, Stenlid, Jan, Lind, Mårten   +5 more
core   +3 more sources

Helicobacter pylori virulence factors in duodenal ulceration: A primary cause or a secondary infection causing chronicity [PDF]

, 2006
Reports from countries with a high prevalence of Helicobacter pylori. (H pylori) infection do not show a proportionately high prevalence of duodenal ulceration, suggesting the possibility that H pylori cannot be a primary cause of duodenal ulceration. It
Hobsley, M, Tovey, FI, Holton, J
core  

Pyruvate formate lyase is required for pneumococcal fermentative metabolism and virulence.

, 2009
Knowledge of the in vivo physiology and metabolism of Streptococcus pneumoniae is limited, even though pneumococci rely on efficient acquisition and metabolism of the host nutrients for growth and survival.
Andrew, Peter W., Homer, Karen A, Spissu, Francesca, Homer, Karen A., Benisty, Rachel, Porat, Nurith, Neves, Ana R., Andrew, Peter W, Yesilkaya, Hasan, Neves, Ana R, Terra, Vanessa S., Carvalho, Sandra M, Terra, Vanessa S, Carvalho, Sandra M.   +13 more
core   +1 more source

Multiple avirulence paralogues in cereal powdery mildew fungi may contribute to parasite fitness and defeat of plant resistance [PDF]

, 2006
Powdery mildews, obligate biotrophic fungal parasites on a wide range of important crops, can be controlled by plant resistance (R) genes, but these are rapidly overcome by parasite mutants evading recognition.
Porritt, Oliver, Jones, Jonathan D. G., Porritt, O, Sacristan, S, Ridout, CJ, Ridout, Christopher J., Brown, James K. M., Skamnioti, Pari, Skamnioti, Paraskevi, Sacristán Benayas, Soledad, Brown, JK, Jones, JD   +11 more
core   +1 more source

A Microcapsule‐Integrated smRandom‐seq Platform Enables Fixation‐Free Single Microbe RNA Sequencing

Advanced Science, EarlyView.
We developed a microcapsule‐integrated high‐throughput fixation‐free single‐microbe RNA‐seq workflow in which microbes are encapsulated in aqueous two‐phase microcapsules for physical confinement of nucleic acids. This platform enables co‐encapsulation with barcoded beads for sequencing and reveals that fixation‐free processing enhances transcriptomic ...
Mengdi Song, Yuting Wang, Zhaolun Wang, Shunji Zhang, Zhengmin Tang, Yongcheng Wang   +5 more
wiley   +1 more source

Distribution of Virulence Factors in Vancomycin-Resistant Enterococci Isolated from Clinical and Intestinal Samples

Microorganisms
Virulence factors in enterococci play an important role in the pathogenesis of enterococcal infection and colonization. The aim was to determine the prevalence of genes encoding virulence factors in VRE from clinical and intestinal samples.
Preslava Mihaylova Hristova
doaj   +1 more source

Comparison of virulence genes found in draft genomes of F. necrophorum [PDF]

, 2015
Fusobacterium necrophorum is a causative agent of persistent sore throat syndrome, tonsillar abscesses and Lemierre’s syndrome (LS) in humans. LS is characterised by thrombophlebitis of the jugular vein and bacteraemia.
Greenwell, P., Kimmitt, P.T., Wright Katie Greenwell Pamela   +2 more
core