Results 61 to 70 of about 268,142 (318)

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Pan-Genome Analysis of Campylobacter: Insights on the Genomic Diversity and Virulence Profile

Microbiology Spectrum, 2022
The genus Campylobacter contains pathogens that cause bacterial gastroenteritis in humans and animals. Despite large-scale sequencing efforts to raise clinical awareness of Campylobacter, little is known about the diversity and functions of virulence ...
Chaofang Zhong, Bingpeng Qu, Gang Hu, Kang Ning   +3 more
doaj   +1 more source

AListeria monocytogenesStrain Is Still Virulent despite Nonfunctional Major Virulence Genes [PDF]

The Journal of Infectious Diseases, 2009
The low-virulence Listeria monocytogenes strains have been previously assigned to 4 phenotypic groups. This study aimed to characterize the A23 strain, which exhibits a pulsed-field gel electrophoresis profile specific to low-virulence strains. This strain has the same causal mutations as the group III strains and a supplementary mutation in the mpl ...
Roche, Sylvie, Grépinet, Olivier, Corde, Yannick, Teixeira-Mechin, Ana-Paula, Kerouanton, A, Temoin, Stephanie, Mereghetti, L, Brisabois, A, Velge, Philippe   +8 more
openaire   +4 more sources

Insect infection model for Campylobacter jejuni reveals that O-methyl phosphoramidate has insecticidal activity

, 2010
Galleria mellonella (wax moth) larvae have elsewhere been shown to be susceptible to pathogens such as Francisella tularensis, Burkholderia mallei, and Pseudomonas aeruginosa.
Champion, O. L., Wren, B. W., Karlyshev, AV, Woodward, M, Senior, NJ, Wren, BW, Champion, OL, Howard, Sarah L, Titball, Richard W, Woodward, Martin J., Howard, SL, Wren, Brendan W, La Ragione, R., Titball, R. W., Champion, Olivia L, Senior, Nicola J, Senior, N. J., Howard, S. L., La Ragione, Roberto, La Ragione, R, Titball, RW, Karlyshev, Andrey V, Karlyshev, A. V., Woodward, Martin   +23 more
core   +1 more source

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, EarlyView.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

Bacterial human virulence genes across diverse habitats as assessed by in silico analysis of environmental metagenomes

Frontiers in Microbiology, 2016
The occurrence and distribution of clinically relevant bacterial virulence genes across natural (non-human) environments is not well understood. We aimed to investigate the occurrence of homologues to bacterial human virulence genes in a variety of ...
Ditte Andreasen Søborg, Niels Bohse Hendriksen, Jan H. Christensen, Mogens Kilian, Niels Kroer   +4 more
doaj   +1 more source

Heterologous expression from Agrobacterium virulence promoters [PDF]

, 1991
The aim of this work was twofold: to construct plasmids with a gene encoding a pesticidal protein expressed from an Agrobacterium tumefaciens virulence promoter and to determine, in planta, the sites of Agrobacterium vir-induction.
Lilley, Catherine Jane, Lilley, C.J
core  

Phylogenomic analysis of natural selection pressure in Streptococcus genomes [PDF]

, 2007
In comparative analyses of bacterial pathogens, it has been common practice to discriminate between two types of genes: (i) those shared by pathogens and their non-pathogenic relatives (core genes), and (ii) those found exclusively in pathogens (pathogen-
Joseph Bielawski, Katherine Dunn, Dunn, K, Yang, Z, Anisimova Maria, Anisimova, Maria, Yang Ziheng, Maria Anisimova, Bielawski, Joseph P., Anisimova, M, Bielawski Joseph, Bielawski, J, Yang, Ziheng, Dunn, Katherine, Dunn Katherine, Ziheng Yang   +15 more
core   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Virulence genes in Enterococcus faecium and Enterococcus faecalis isolated from blood culture in haematological patients [PDF]

Клиническая микробиология и антимикробная химиотерапия
Objective. To study virulence genes in E. faecium and E. faecalis isolated from the blood cultures of patients with hematological diseases. Materials and Methods. Virulence genes were studied in E. faecium and E.
Fedorova A.V., Khrulnova S.A., Vetokhina A.V., Molchanova I.V., Kutsevalova O.Yu., Klyasova G.A.   +5 more
doaj   +1 more source