Results 131 to 140 of about 171,270 (316)

The poly (A) polymerase pcnB modulates virulence and resistance in Klebsiella pneumoniae by differentially regulating chromosomal mRNA stability and plasmid copy number

Frontiers in Microbiology
Klebsiella pneumoniae is a leading cause of healthcare-associated infections, with emerging strains exhibiting both multidrug resistance and hypervirulence, largely mediated by plasmid-encoded genes.
Liaoqin Zhang, Shujie Zhang, Jun Wang, Zhongdong Zhang, Yong Xu, Chen Zhang   +5 more
doaj   +1 more source

Epidemiology of virulence-associated plasmids and outer membrane protein patterns within seven common Salmonella serotypes [PDF]

, 1985
Reiner Helmuth, R. Stephan, Cornelia Bunge, Bernhard Hoog, A. Steinbeck, E. Bulling   +5 more
openalex   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Mechanisms to Evade the Phagocyte Respiratory Burst Arose by Convergent Evolution in Typhoidal Salmonella Serovars. [PDF]

, 2018
Typhoid fever caused by Salmonella enterica serovar (S.) Typhi differs in its clinical presentation from gastroenteritis caused by S. Typhimurium and other non-typhoidal Salmonella serovars.
Bäumler, Andreas J, Cobb, Brian A, Hiyoshi, Hirotaka, Lock, Gabriel, Raffatellu, Manuela, Saechao, Cheng, Wangdi, Tamding   +6 more
core   +2 more sources

Emergence of IS26-mediated pLVPK-like virulence and NDM-1 conjugative fusion plasmid in hypervirulent carbapenem-resistant Klebsiella pneumoniae

, 2023
Chongmei Tian, Yueyue Shi, Lingzhi Ren, Delian Huang, Siwei Wang, Yaping Zhao, Liping Fu, Yongfeng Bai, Daozong Xia, Xueyu Fan   +9 more
openalex   +1 more source

Macrophage extracellular vesicles deliver Mef2d proteins to aggravate Bacteroides fragilis pathogenicity in type 2 diabetes arterial calcification

Interdisciplinary Medicine, EarlyView.
Bacteroides fragilis is associated with type 2 diabetes (T2D) arterial calcification and can be activated by macrophage‐derived extracellular vesicles (EVs). BF takes up EVs via receptor‐mediated endocytosis, and activation is induced by EV‐derived Mef2d, thereby inhibiting ArsR family transcriptional regulator transcription.
Cong Chen, Rong He, Jirong Luo, Zhengfeng Liang, Qunwen Pan, Shuangquan Liu, Jingsong Cao   +6 more
wiley   +1 more source

Molecular characteristics and pathogenic mechanisms of KPC-3 producing hypervirulent carbapenem-resistant Klebsiella pneumoniae (ST23-K1)

Frontiers in Cellular and Infection Microbiology
ObjectiveThis study aimed to comprehensively investigate hypervirulent carbapenem-resistant Klebsiella pneumoniae (CR-hvKP) in the Ningbo region. Importantly, we sought to elucidate its molecular characteristics and pathogenic mechanisms.
Yanye Tu, Hui Gao, Rongqing Zhao, Jiliang Yan, Xingbing Wu   +4 more
doaj   +1 more source

Additional file 2 of Modular evolution of secretion systems and virulence plasmids in a bacterial species complex

, 2022
Lin Chou, Yu-Chen Lin, Mindia Haryono, Mary Nia M. Santos, Shu‐Ting Cho, Alexandra J. Weisberg, Chih‐Feng Wu, Jeff H. Chang, Erh‐Min Lai, Chih‐Horng Kuo   +9 more
openalex   +1 more source

Genomic Insights Into Carbapenem‐Resistant Klebsiella pneumoniae in Pediatric Bloodstream Infections in Zhejiang, China (2019–2024)

Journal of Clinical Laboratory Analysis, EarlyView.
The primary mechanism of carbapenem resistance identified in pediatric CRKP‐BSI strains was the production of Class B metalloenzymes. We report, for the first time, an outbreak of bloodstream infections in a neonatal ward caused by the dissemination of NDM‐1‐producing ST25 K. pneumoniae.
Mingming Zhou, Xiucai Zhang, Zhenjie Chen, Chao Fang, Shixing Liu, Jintao Xia, Yining Zhao, Chenmei Zhang, Hongqiang Shen   +8 more
wiley   +1 more source

Antimicrobial resistance of Yersinia enterocolitica and presence of plasmid pYV virulence genes in human and animal isolates

New Microbes and New Infections, 2019
Interactions between bacterial virulence and antimicrobial resistance are of increasing interest in clinical microbiology. On this account, antimicrobial resistance of Yersinia enterocolitica O:3 strains isolated from humans (n = 55), food-chain animals (
T. Gkouletsos, K. Patas, G. Lambrinidis, H. Neubauer, L.D. Sprague, A. Ioannidis, S. Chatzipanagiotou   +6 more
doaj   +1 more source