Results 131 to 140 of about 104,714 (231)

Regulation of the Yersinia pseudotuberculosis Type III Secretion System by the CpxAR Two‐Component System

Molecular Microbiology, EarlyView.
Host tissue cues including temperature, oxygen, and iron availability regulate expression of the Yersinia type III secretion system (T3SS) master regulator LcrF. We found that CpxR inhibits LcrF through an indirect, multi‐factorial mechanism and identified the osmolarity‐sensing OmpR/EnvZ system as an additional regulator of LcrF, highlighting ...
Karen Hug, Erin Mettert, Melissa Estrada Escobar, Cristina Vargas Vazquez, David Balderas, Sarvind Tripathi, Laya Ashley, Patricia J. Kiley, Victoria Auerbuch   +8 more
wiley   +1 more source

Hypervirulent Klebsiella pneumoniae Sequence Type 420 with a Chromosomally Inserted Virulence Plasmid. [PDF]

Int J Mol Sci, 2021
Eger E, Heiden SE, Becker K, Rau A, Geisenhainer K, Idelevich EA, Schaufler K.   +6 more
europepmc   +1 more source

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

Molecular Microbiology, EarlyView.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan, Sourav Roy, Revathi Govind   +2 more
wiley   +1 more source

Chain‐Length Regulation by WzzE Is Necessary for, but Genetically Separable From, Cyclic Enterobacterial Common Antigen Synthesis

Molecular Microbiology, EarlyView.
Here, we demonstrate that polysaccharide chain length regulation plays a distinct role in enabling formation of a cyclic molecule important for the bacterial cell surface. However, this function is necessary, but not sufficient for the cyclic molecule's biosynthesis.
Joseph F. Carr, Yohannes H. Rezenom, Jennifer S. Rudolf, Daniel J. Warzecha, Angela M. Mitchell   +4 more
wiley   +1 more source

LURP1, a SARD1‐regulated protein, coordinates with the helper NLR ADR1 to promote plant immunity

New Phytologist, EarlyView.
The working model of LURP1 function in plant immunity. Upon pathogen infection, SARD1/CBP60g promotes the transcription of LURP1 directly. LURP1 likely functions as an adaptor protein that associates with the PRRs–BAK1 complexes at the plasma membrane (PM) while also interacts with the ADR1 family helper NLRs.
Xueru Liu, Weijie Huang, Zhengxi Gong, Chenying Li, Siyu Chen, Shucai Wang, Yuelin Zhang, Xin Li   +7 more
wiley   +1 more source

Acquisition of the Conjugative Virulence Plasmid From a CG23 Hypervirulent Klebsiella pneumoniae Strain Enhances Bacterial Virulence. [PDF]

Front Cell Infect Microbiol, 2021
Tian D, Wang W, Li M, Chen W, Zhou Y, Huang Y, Sheng Z, Jiang X.   +7 more
europepmc   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Role of the Yersinia pseudotuberculosis Virulence Plasmid in Pathogen-Phagocyte Interactions in Mesenteric Lymph Nodes. [PDF]

EcoSal Plus, 2021
Bliska JB, Brodsky IE, Mecsas J.
europepmc   +1 more source

The ComEA/ComEC Operon is Critical for Nitrosative Stress Tolerance by an Oral Commensal

Molecular Oral Microbiology, EarlyView.
ABSTRACT Oral commensal streptococci play a large role in mediating microbial homeostasis. Our prior work has demonstrated that hydrogen peroxide (H2O2) produced by oral commensal streptococci can react with salivary nitrite (NO2) and generate peroxynitrite (ONOO−), a potent antimicrobial.
Sara E. Edmonds, Hernan Grenett, Priscilla Grenett, Jessica A. Scoffield   +3 more
wiley   +1 more source

Isolation of Hv-CRKP with co-production of three carbapenemases (bla_KPC, bla_OXA-181 or _OXA-232, and bla_NDM-1) and a virulence plasmid: a study from a Chinese tertiary hospital. [PDF]

Front Microbiol, 2023
Li P, Luo WY, Xiang TX, Peng TX, Luo S, He ZY, Liao W, Wei DD, Liu P, Wan LG, Zhang W, Liu Y.   +11 more
europepmc   +1 more source