Results 51 to 60 of about 2,401,730 (258)

Characterisation of the effects of salicylidene acylhydrazide compounds on type three secretion in Escherichia coli O157:H7 [PDF]

, 2009
Recent work has highlighted a number of compounds that target bacterial virulence by affecting gene regulation. In this work, we show that small-molecule inhibitors affect the expression of the type III secretion system (T3SS) of <i>Escherichia ...
Layton, Abigail, Stevens, M. P., Tree, J.J., Stevens, Mark P, Tree, J. J., Roe, A. J., McInally, C., Roe, Andrew J, Tree, Jai J, Wang, Dai, Elofsson, M., Houghton, I., Mahajan, A., Stevens, M.P., Gally, D. L., Roe, A.J., Wang, D., Gally, D.L., Layton, A., Elofsson, Mikael,, McInally, Carol, Houghton, Irene, Mahajan, Arvind, Gally, David L   +23 more
core   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Xanthomonas oryzae pv. oryzae RpfE Regulates Virulence and Carbon Source Utilization without Change of the DSF Production

The Plant Pathology Journal, 2013
It has been known that most regulation of pathogenicity factor (rpf) genes in xanthomonads regulates virulence in response to the diffusible signal factor, DSF.
Jung-Hee Cho, Joo-Mi Yoon, Sang-Won Lee, Young-Hee Noh, Jae-Soon Cha   +4 more
doaj   +1 more source

Copy Number of an Integron-Encoded Antibiotic Resistance Locus Regulates a Virulence and Opacity Switch in Acinetobacter baumannii AB5075

mBio, 2020
We describe a novel genetic mechanism in which tandem amplification of a plasmid-borne integron regulates virulence, opacity variation, and global gene expression by altering levels of a putative small RNA (sRNA) in Acinetobacter baumannii AB5075.
Sarah E. Anderson, Chui Yoke Chin, David S. Weiss, Philip N. Rather   +3 more
doaj   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

SSR42 is a novel regulator of cytolytic activity in Staphylococcus aureus

mBio
SSR42 is the longest noncoding RNA in the Staphylococcus aureus cell and the second-most abundant transcript in the stationary-phase transcriptome, second only to RNAIII.
Mary-Elizabeth Jobson, Brooke R. Tomlinson, Emilee M. Mustor, Emily A. Felton, Andy Weiss, Clayton C. Caswell, Lindsey N. Shaw   +6 more
doaj   +1 more source

Evolution of malaria virulence in cross-generation transmission through selective immune pressure [PDF]

, 2007
Theoretical arguments and some mathematical models of host-parasite coevolution (e.g. [1- 6]) suggest host immunity as the driving source for the evolution of parasite virulence.
David E. Gurarie
core  

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Stress-dependent activation of the Listeria monocytogenes virulence program ensures bacterial resilience during infection

mBio
Listeria monocytogenes (Lm) is a Gram-positive, facultative intracellular pathogen that uses both a housekeeping (P1) and stress-activated (Sigma B-dependent) promoter (P2) to express the master virulence regulator PrfA. The Sigma B regulon contains over
Mariya Lobanovska, Ying Feng, Jonathan Zhang, Allison H. Williams, Daniel A. Portnoy   +4 more
doaj   +1 more source

Mycobacterium tuberculosis acg Gene Is Required for Growth and Virulence In Vivo. [PDF]

, 2011
Mycobacterium tuberculosis dosRS two-component regulatory system controls transcription of approximately 50 genes including hspX, acg and Rv2030c, in response to hypoxia and nitric oxide conditions and within macrophages and mice.
Hu, Y, Yanmin Hu, Hu Yanmin, Anthony R M Coates, Anthony R. M. Coates, Coates, AR, Coates Anthony R. M.   +6 more
core   +2 more sources