Results 41 to 50 of about 2,401,730 (258)

Unique cell adhesion and invasion properties of Yersinia enterocolitica O:3, the most frequent cause of human Yersiniosis. [PDF]

, 2011
Many enteric pathogens are equipped with multiple cell adhesion factors which are important for host tissue colonization and virulence. Y. enterocolitica, a common food-borne pathogen with invasive properties, uses the surface proteins invasin and YadA ...
Eckhard Strauch, Rohde, Manfred, Skurnik Mikael, Julia Batzilla, Tatjana Stolz, Fabio Pisano, Mikael Skurnik, Fruth Angelika, Heesemann, Jürgen, Uliczka, Frank, Alexander Rakin, Strauch Eckhard, Petra Dersch, Pisano Fabio, Manfred Rohde, Skurnik, Mikael, Strauch, Eckhard, Frank Uliczka, Jürgen Heesemann, Stolz Tatjana, Heesemann Jürgen, Rakin Alexander, Pisano, Fabio, Julia Schaake, Rohde Manfred, Schaake, Julia, Rakin, Alexander, Stolz, Tatjana, Fruth, Angelika, Angelika Fruth, Uliczka Frank, Batzilla, Julia, Schaake Julia, Batzilla Julia, Dersch, Petra, Dersch Petra, Rakin, Alexander V., Strauch, E., Stolz, T., Pisano, F., Fruth, A., Batzilla, J., Skurnik, M., Schaake, J., Dersch, P., Uliczka, F., Heesemann, J., Rohde, M.   +47 more
core   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

The yad and yeh fimbrial loci influence gene expression and virulence in enterohemorrhagic Escherichia coli O157:H7

mSphere
Fimbriae are essential virulence factors for many bacterial pathogens. Fimbriae are extracellular structures that attach bacteria to surfaces. Thus, fimbriae mediate a critical step required for any pathogen to establish infection by anchoring a ...
Laura A. Gonyar, Amber B. Sauder, Lindsay Mortensen, Graham G. Willsey, Melissa M. Kendall   +4 more
doaj   +1 more source

Cytosolic pH Controls Fungal MAPK Signaling and Pathogenicity

mBio, 2023
Mitogen-activated protein kinases (MAPKs) regulate a variety of cellular processes in eukaryotes. In fungal pathogens, conserved MAPK pathways control key virulence functions such as infection-related development, invasive hyphal growth, or cell wall ...
Tânia R. Fernandes, Melani Mariscal, Antonio Serrano, David Segorbe, Teresa Fernández-Acero, Humberto Martín, David Turrà, Antonio Di Pietro   +7 more
doaj   +1 more source

Parasite variation and the evolution of virulence in a Daphnia-microparasite system [PDF]

, 2008
Understanding genetic relationships amongst the life-history traits of parasites is crucial for testing hypotheses on the evolution of virulence. This study therefore examined variation between parasite isolates (the bacterium Pasteuria ramosa) from the ...
Little, T. J., Chadwick, W., Watt, K.
core   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Mycobacterium tuberculosis PhoP integrates stress response to intracellular survival by regulating cAMP level

eLife
Survival of Mycobacterium tuberculosis within the host macrophages requires the bacterial virulence regulator PhoP, but the underlying reason remains unknown.
Hina Khan, Partha Paul, Harsh Goar, Bhanwar Bamniya, Navin Baid, Dibyendu Sarkar   +5 more
doaj   +1 more source

Streptococcus pyogenes Hijacks Host Glutathione for Growth and Innate Immune Evasion

mBio, 2022
The nasopharynx and the skin are the major oxygen-rich anatomical sites for colonization by the human pathogen Streptococcus pyogenes (group A Streptococcus [GAS]).
Stephan Brouwer, Magnus G. Jespersen, Cheryl-lynn Y. Ong, David M. P. De Oliveira, Bernhard Keller, Amanda J. Cork, Karrera Y. Djoko, Mark R. Davies, Mark J. Walker   +8 more
doaj   +1 more source

Hydrogels Augmented With Artificial Sweeteners can Inhibit Multidrug‐Resistant Acinetobacter baumannii Growth and Biofilm Formation While Demonstrating Safety in Pre‐Clinical Pilot Human Trials

Advanced Healthcare Materials, EarlyView.
Using PVA–borax hydrogels as carriers for off‐the‐shelf artificial sweeteners to fight multidrug‐resistant A. baumannii. These soft, biocompatible hydrogels rapidly reduce bacterial viability within multidrug‐resistant A. baumannii biofilms by more than 99% within one hour and sustain antimicrobial activity over time, while demonstrating safety in both
Jie Han, Mohamed Soliman, Bin Zhang, Dominika Krawiel, Ronan R. McCarthy   +4 more
wiley   +1 more source

The two-component system ArlRS is essential for wall teichoic acid glycoswitching in Staphylococcus aureus

mBio
Staphylococcus aureus is among the leading causes of hospital-acquired infections. Critical to S. aureus biology and pathogenesis are the cell wall-anchored glycopolymers wall teichoic acids (WTA). Approximately one-third of S.
Marieke M. Kuijk, Emma Tusveld, Esther Lehmann, Rob van Dalen, Iñigo Lasa, Hanne Ingmer, Yvonne Pannekoek, Nina M. van Sorge   +7 more
doaj   +1 more source