Results 31 to 40 of about 2,401,730 (258)

Killing them softly:managing pathogen polymorphism and virulence in spatially variable environments [PDF]

, 2013
Understanding why pathogen populations are genetically variable is vital because genetic variation fuels evolution, which often hampers disease control efforts.
Vale, Pedro F; id_orcid, Vale, Pedro F.
core   +1 more source

Identification of Group A Streptococcus Genes Directly Regulated by CsrRS and Novel Intermediate Regulators

mBio, 2021
Adaptation of group A Streptococcus (GAS) to its human host is mediated by two-component systems that transduce external stimuli to regulate bacterial physiology.
Meredith B. Finn, Kathryn M. Ramsey, Simon L. Dove, Michael R. Wessels   +3 more
doaj   +1 more source

The ability to utilize mucin affects the regulation of virulence gene expression in Streptococcus pneumoniae.

, 2008
Streptococcus pneumoniae colonizes the mucin-rich environment of the nasopharynx. As colonization may be the first stage of infection, investigation was carried out as to whether the pneumococcus could utilize mucin as a source of nutrient and whether ...
Manco, Sonia, Kadioglu, Aras, Andrew, Peter W, Yesilkaya, Hasan, Terra, Vanessa S   +4 more
core   +1 more source

Evolutionary trade-offs underlie the multi-faceted virulence of Staphylococcus aureus [PDF]

, 2015
Date of Acceptance: 20/07/2015Bacterial virulence is a multifaceted trait where the interactions between pathogen and host factors affect the severity and outcome of the infection. Toxin secretion is central to the biology of many bacterial pathogens and
Williams, Barnabas, Uhlemann, Anne-Catrin, Edward Feil, Recker, Mario, Maisem Laabei (311431), Lowy, FD, Clarke, SR, Janina Dordel (250569), Janina Dordel, Votintseva, Antonina A., Lowy, Franklin D., Votintseva, AA, Austin, ED, Wilson, Daniel J, Bowden, Rory, Wilson, Daniel J., Daniel J. Wilson (194149), Matthew Holden, Crook, Derrick W., Dordel, Janina, Derrick W Crook, Maho Yokoyama (791513), Thorpe, Harry A, Holden, Matthew, Matthew Holden (791517), Sharon J. Peacock (35782), Derrick W. Crook (145636), Austin, Eloise D, Williams, B, Mario Recker (88496), Sharon J Peacock, Eloise D Austin, Perkins, Mark, Votintseva, Antonina A, Barnabas Williams (791515), Recker, M, Mario Recker, Franklin D Lowy, Young, Bernadette C, Khadija Ouadi, Ouadi, Khadija, Eloise D. Austin (791512), Rory Bowden (179995), Crook, Derrick, Wilson, DJ, Barnabas Williams, Bernadette C Young, Maho Yokoyama, Yokoyama, Maho, Clark, Stephen Robert, Harry A Thorpe, Franklin D. Lowy (299074), Uhlemann, AC, Feil, E, Edward Feil (270047), Anne-Catrin Uhlemann, Stephen R Clarke, Ouadi, K, Antonina A Votintseva, Clarke, Stephen R, Peacock, Sharon J., Mark Perkins, Peacock, SJ, Laabei, M, Ruth C. Massey (174217), Maisem Laabei, Antonina A. Votintseva (791518), Harry A. Thorpe (791514), Austin, Eloise D., Young, BC, Peacock, Sharon J, Massey, Ruth C., Mark Perkins (254177), Bernadette C. Young (408943), Massey, RC, Crook, DW, Thorpe, HA, Clarke, Stephen R., Feil, Edward, Anne-Catrin Uhlemann (299063), Wilson, Daniel, Crook, Derrick W, Laabei, Maisem, Khadija Ouadi (598087), Perkins, M, Lowy, Franklin D, Daniel J Wilson, Rory Bowden, Stephen R. Clarke (791516), Bowden, R, Dordel, J, Massey, Ruth C, Young, Bernadette C., Thorpe, Harry A., Yokoyama, M, Holden, M, Ruth C Massey   +96 more
core   +1 more source

Evolution towards Virulence in a Burkholderia Two-Component System

mBio, 2021
Bacteria in the Burkholderia cepacia complex (BCC) are significant pathogens for people with cystic fibrosis (CF) and are often extensively antibiotic resistant.
Matthew M. Schaefers, Benjamin X. Wang, Nicole M. Boisvert, Sarah J. Martini, Sarah L. Bonney, Christopher W. Marshall, Michael T. Laub, Vaughn S. Cooper, Gregory P. Priebe   +8 more
doaj   +1 more source

Steps toward broad-spectrum therapeutics : discovering virulence-associated genes present in diverse human pathogens [PDF]

, 2009
© 2009 Stubben et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Karlyshev, Andrey V., Gans, Jason D, Oyston, Petra C. F., Ford, Donna C., Gans, Jason D., Wolinsky Murray, Titball, Richard W., Cooper, Ian A, Karlyshev, Andrey, Wren, Brendan W, Cooper Ian A, Duffield Melanie L, Duffield, Melanie, Ford Donna C, Lingard, Bryan, Ford, Donna C, Stubben, Chris J., Wren, Brendan W., Oyston, Petra CF, Karlyshev, Andrey V, Titball, Rick W, Lingard, Brian, Duffield, Melanie L, Karlyshev Andrey V, Gans Jason D, Oyston Petra CF, Song, Jian, Stubben, Chris J, Oyston, Petra C F, Titball Rick W, de Rochefort Anna, Stubben Chris J, Wren Brendan W, Lingard Bryan, Wolinsky, Murray, de Rochefort, Anna, Cooper, Ian A., Song Jian   +37 more
core   +1 more source

A highly conserved tRNA modification contributes to C. albicans filamentation and virulence

Microbiology Spectrum
tRNA modifications play important roles in maintaining translation accuracy in all domains of life. Disruptions in the tRNA modification machinery, especially of the anticodon stem loop, can be lethal for many bacteria and lead to a broad range of ...
Bettina Böttcher, Sandra D. Kienast, Johannes Leufken, Cristian Eggers, Puneet Sharma, Christine M. Leufken, Bianka Morgner, Hannes C. A. Drexler, Daniela Schulz, Stefanie Allert, Ilse D. Jacobsen, Slavena Vylkova, Sebastian A. Leidel, Sascha Brunke   +13 more
doaj   +1 more source

Plant Signals Anticipate the Induction of the Type III Secretion System in Pseudomonas syringae pv. actinidiae, Facilitating Efficient Temperature-Dependent Effector Translocation

Microbiology Spectrum, 2022
Disease resistance in plants depends on a molecular dialogue with microbes that involves many known chemical effectors, but the time course of the interaction and the influence of the environment are largely unknown.
Maria Rita Puttilli, Davide Danzi, Cristiana Correia, Jessica Brandi, Daniela Cecconi, Marcello Manfredi, Emilio Marengo, Conceição Santos, Francesco Spinelli, Annalisa Polverari, Elodie Vandelle   +10 more
doaj   +1 more source

Passaging of a Newcastle disease virus pigeon variant in chickens results in selection of viruses with mutations in the polymerase complex enhancing virus replication and virulence [PDF]

, 2010
Some Newcastle disease virus (NDV) variants isolated from pigeons (pigeon paramyxovirus type 1; PPMV-1) do not show their full virulence potential for domestic chickens but may become virulent upon spread in these animals.
Peeters, B.P.H., Strategic Infection Biology, Dep Infectieziekten Immunologie, G. Koch, B. P. H. Peeters, Rottier, P.J.M., Dortmans, J.C.F.M., J. C. F. M. Dortmans, P. J. M. Rottier, Koch, G.   +9 more
core   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source