Results 91 to 100 of about 5,037,505 (267)

Transcriptional profiling of zebrafish intestines identifies macrophages as host cells for human norovirus infection

Gut Microbes
Human noroviruses (HuNoVs) are a major cause of diarrheal disease, yet critical aspects of their biology, including cellular tropism, remain unclear.
Emma Roux, Reegan J. Willms, Jana Van Dycke, Álvaro Cortes Calabuig, Lore Van Espen, Geert Schoofs, Jelle Matthijnssens, Johan Neyts, Peter de Witte, Edan Foley, Joana Rocha-Pereira   +10 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Utilising proteomic approaches to understand oncogenic human herpesviruses [PDF]

, 2014
The γ‑herpesviruses Epstein-Barr virus and Kaposi's sarcoma‑associated herpesvirus are successful pathogens, each infecting a large proportion of the human population.
Owen, Christopher B, Hughes, DJ, Berndt, Anja, Schumann, Sophie, Whitehouse, A, Jackson, BR, Whitehouse, Adrian, Baquero-Perez, Belinda, Jackson, Brian R, Berndt, A, Owen, CB, Hughes, David J, Baquero-Perez, B, Schumann, S   +13 more
core   +1 more source

SARS-CoV-2 entry and fusion are independent of ACE2 localization to lipid rafts

Journal of Virology
Membrane fusion occurs at the early stages of SARS-CoV-2 replication, during entry of the virus, and later during the formation of multinucleated cells called syncytia.
William Bolland, Inès Marechal, Chloé Petiot, Françoise Porrot, Florence Guivel-Benhassine, Anne Brelot, Nicoletta Casartelli, Olivier Schwartz, Julian Buchrieser   +8 more
doaj   +1 more source

Covalent Functionalization of 2D Semiconductors: A Roadmap to Advanced Electronic Devices

Advanced Functional Materials, EarlyView.
This Review presents recent advances in the covalent functionalization strategies for two‐dimensional semiconductors and their implementation in modern technologies. Layered materials are modified through diverse molecular chemistries (e.g., thiols, diazonium salts, alkyl halides, and electron‐deficient species) to tailor their surface properties ...
Ramiro Quirós‐Ovies, Bin Han, Paolo Samorì   +2 more
wiley   +1 more source

Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease

Nature Communications
Hepatitis C virus (HCV) exists as a heterogenous quasispecies, but the phenotypic consequences of viral variability are widely unexplored. Here we identify a replication enhancing domain (ReED) in non-structural protein 5A conferring high replication ...
Paul Rothhaar, Tomke Arand, Ha Gyu-Thomas Seong, Christian Heuss, Margaret Tulessin, Zhiqing Wang, Colin Förster, Alina C. Schneider, Jocelyn Quistrebert, Haiting Chai, Marvin Reineke, Louise Benning, Jonathan Honegger, Maike Hofmann, Robert Thimme, Jörg Timm, STOPHCV investigators, Paul Schnitzler, Uta Merle, Naglaa H. Shoukry, Julie Bruneau, Chaturaka Rodrigo, Andrew Lloyd, Rowena A. Bull, M. Azim Ansari, Carolin Mogler, John McLauchlan, Xavier Forns, Sofía Pérez-del-Pulgar, Volker Lohmann   +29 more
doaj   +1 more source

Uncovering Virus-Virus Interactions by Unifying Approaches and Harnessing High-Throughput Tools

mSystems, 2019
Virus-host interactions have received much attention in virology. Virus-virus interactions can occur when >1 virus infects a host and can be deemed social when one virus affects the fitness of another virus, as in the well-known case of superinfection ...
Samuel L. Díaz-Muñoz
doaj   +1 more source

Nano Borophene as a Programmable 2D Scaffold for Organized DNA Assembly and Long‐Range Energy Transfer

Advanced Functional Materials, EarlyView.
Borophene is introduced as a programmable 2D bio‐interface that organizes DNA through dual boron–sulfur and nucleobase interactions. This molecular architecture enables efficient long‐range nanosurface energy transfer, establishing new design principles for functional nano–bio interfaces and amplification‐free optical biosensing.
Teresa Aditya, Pranay Saha, John M. Sansalone, Shraddha Krishnakumar, Matthew Molinaro, André J. van der Vlies, Nada Maher, Adrienne Griffiths, Zakhro Zakirova, Ketan Dighe, Narayana R. Aluru, Dipanjan Pan   +11 more
wiley   +1 more source

Insights into neutralization of animal viruses gained from study of influenza virus [PDF]

, 1991
It has long been known that the binding of antibodies to viruses can result in a loss of infectivity, or neutralization, but little is understood of the mechanism or mechanisms of this process.
Outlaw, Mark C., Dimmock, N. J.
core   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source