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Bioinformatics approaches for unveiling virus-host interactions [PDF]

open access: yesComputational and Structural Biotechnology Journal, 2023
The coronavirus disease-2019 (COVID-19) pandemic has elucidated major limitations in the capacity of medical and research institutions to appropriately manage emerging infectious diseases.
Hitoshi Iuchi   +8 more
doaj   +2 more sources

Comodulation of Dengue and Chikungunya Virus Infection During a Coinfection Scenario in Human Cell Lines

open access: yesFrontiers in Cellular and Infection Microbiology, 2022
The Dengue virus (DENV) and Chikungunya virus (CHIKV) are the arboviruses that pose a threat to global public health. Coinfection and antibody-dependent enhancement are major areas of concern during DENV and CHIKV infections, which can alter the clinical
Debjani Taraphdar   +9 more
doaj   +1 more source

Viral Hijack of Filamentous Surface Structures in Archaea and Bacteria

open access: yesViruses, 2021
The bacterial and archaeal cell surface is decorated with filamentous surface structures that are used for different functions, such as motility, DNA exchange and biofilm formation. Viruses hijack these structures and use them to ride to the cell surface
Colin Tittes   +2 more
doaj   +1 more source

Archaeal Host Cell Recognition and Viral Binding of HFTV1 to Its Haloferax Host

open access: yesmBio, 2023
Viruses are highly abundant and the main predator of microorganisms. Microorganisms of each domain of life are infected by dedicated viruses. Viruses infecting archaea are genomically and structurally highly diverse.
Sabine Schwarzer   +3 more
doaj   +1 more source

Structural insights into the mechanism of archaellar rotational switching

open access: yesNature Communications, 2022
Signal transduction via phosphorylated CheY is conserved in bacteria and archaea. In this study, the authors employ structural biochemistry combined with cell biology to delineate the mechanism of CheY recognition by the adaptor protein CheF.
Florian Altegoer   +10 more
doaj   +1 more source

Cellular and Genomic Properties of Haloferax gibbonsii LR2-5, the Host of Euryarchaeal Virus HFTV1

open access: yesFrontiers in Microbiology, 2021
Hypersaline environments are the source of many viruses infecting different species of halophilic euryarchaea. Information on infection mechanisms of archaeal viruses is scarce, due to the lack of genetically accessible virus–host models. Recently, a new
Colin Tittes   +7 more
doaj   +1 more source

Growth Phase Dependent Cell Shape of Haloarcula

open access: yesMicroorganisms, 2021
Several haloarchaea are reported to be pleomorphic, while others exhibit remarkable shapes, such as squares. Recently, Haloferax volcanii was found to alter its morphology during growth.
Sabine Schwarzer   +3 more
doaj   +1 more source

Decreased MIP-3α Production from Antigen-Activated PBMCs in Symptomatic HIV-Infected Subjects

open access: yesPathogens, 2021
CD4+ CCR6+ T cells are highly susceptible to HIV infection, and a high cytokine producing CCR6+ T cell subset is selectively lost during HIV infection. The CCR6 chemokine MIP-3α (CCL20) is produced at sites of infection in SIV animal models. Recently, we
Fuchun Zhang   +4 more
doaj   +1 more source

Reassessment of the capacity of the HIV-1 Env cytoplasmic domain to trigger NF-κB activation

open access: yesVirology Journal, 2018
The cytoplasmic domain of lentiviral Envelopes (EnvCD) ensures Env incorporation into nascent virions and regulates Env trafficking to and from the plasma membrane.
Cyprien Beraud   +2 more
doaj   +1 more source

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