Results 61 to 70 of about 6,133,142 (332)

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
core   +1 more source

Effects of extracellular K+ on grapevine membrane potential as influenced by the antiviral mycophenolic acid. An electrophysiological study

Advances in Horticultural Science, 2015
Mycophenolic acid (MPA) is an effective antiviral drug in plants, and its action in modulating the activity of KATP channels is already known in animals.
Andrea Luvisi, Enrico Rinaldelli, A. Panattoni   +2 more
doaj   +1 more source

Exploitation of Host Factors and Cellular Pathways by Tombusviruses for the Biogenesis of the Viral Replication Organelles

Proceedings, 2020
Plus-stranded RNA viruses recruit cellular vesicles and co-opt cellular proteins involved in cellular metabolism and lipid biosynthesis to build viral replicase complexes (VRCs) within the large viral replication compartments. We use tombusviruses (TBSV),
Peter D. Nagy
doaj   +1 more source

Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody [PDF]

, 2010
<b>BACKGROUND:</b> In the acute phase of infection with feline immunodeficiency virus (FIV), the virus targets activated CD4+ T cells by utilising CD134 (OX40) as a primary attachment receptor and CXCR4 as a co-receptor.
Brian J Willett, Margaret J Hosie, Ayman Samman, McMonagle, Elizabeth L., Logan, Nicola, Nicola Logan, Hosie, Margaret J., Samman, Ayman, Willett, Brian J., Kraase, Martin, Martin Kraase, Elizabeth L McMonagle   +11 more
core   +1 more source

Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation [PDF]

, 2010
End-stage liver disease caused by chronic hepatitis C virus (HCV) infection is a leading cause for liver transplantation (LT). Due to viral evasion from host immune responses and the absence of preventive antiviral strategies, reinfection of the graft is
Pessaux, Patrick, Doffoel, Michel, Leroux-Roels, G., Stoll-Keller, Françoise, Michel Doffoël, Patel, Arvind H, Samira Fafi-Kremer, Fofana, I., Soulier, E., Patric Carolla, Fafi-Kremer, S., Doffoel, M., Stoll-Keller, F., Cosset, F.-L., Meuleman, Philip, Fafi-Kremer, Samira, Eric Soulier, Philip Meuleman, Isabel Fofana, Wolf, P., Soulier, Eric, Cosset, François-Loic, François-Loïc Cosset, Leroux-Roels, Geert, Wolf, Philippe, Françoise Stoll-Keller, Philippe Wolf, Carolla, Patric, Pessaux, P., Meuleman, P., Baumert, Thomas F, Patel, A.H., Fofana, Isabel, Patrick Pessaux, Thomas F. Baumert, Arvind H. Patel, Geert Leroux-Roels, Carolla, P., Baumert, T.F.   +38 more
core   +1 more source

Targeting Virus-host Interactions of HIV Replication

Current Topics in Medicinal Chemistry, 2015
Cellular proteins that are hijacked by HIV in order to complete its replication cycle, form attractive new targets for antiretroviral therapy. In particular, the protein-protein interactions between these cellular proteins (cofactors) and viral proteins are of great interest to develop new therapies.
Weydert, Caroline, De Rijck, Jan, Christ, Frauke, Debyser, Zeger   +3 more
openaire   +2 more sources

Paradoxical Interplay of Viral and Cellular Functions

Viruses, 2011
Some cellular editing functions can restrict the replication of some viruses but contribute to completion of the life cycle of others. A recent study has identified an isoform of the adenosine deaminase acting on RNA type 1 (ADAR 1) as required for ...
Esteban Domingo
doaj   +1 more source

Characterization of influenza A virus induced transposons reveals a subgroup of transposons likely possessing the regulatory role as eRNAs

Scientific Reports, 2022
Although many studies have observed genome-wide host transposon expression alteration during viral infection, the mechanisms of induction and the impact on the host remain unclear. Utilizing recently published influenza A virus (IAV) time series data and
Steven S. Shen, Hezkiel Nanda, Constantin Aliferis, Ryan A. Langlois   +3 more
doaj   +1 more source

Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction

Viruses, 2016
Enterovirus genus includes multiple important human pathogens, such as poliovirus, coxsackievirus, enterovirus (EV) A71, EV-D68 and rhinovirus. Infection with EVs can cause numerous clinical conditions including poliomyelitis, meningitis and encephalitis,
X. Lei, Xia Xiao, Jianwei Wang
semanticscholar   +1 more source

Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag?TSG101 interaction

, 2008
The egress of HIV particles from virus-infected cells is accomplished by the recruitment of proteins that normally mediate host cell endocytic functions.
Gam, Jongsik, Cohen, Stanley N., Benkovic, Stephen J., Pans, Hui, Tavassoli, Ali, Lu, Quan   +5 more
core   +1 more source