Results 61 to 70 of about 5,926,015 (303)

The Role of Lactylation in Virus–Host Interactions

International Journal of Molecular Sciences
Lactylation, a novel form of post-translational modifications (PTMs) of protein, particularly within histone proteins, has recently gained attention for its role in regulating gene expression and cellular processes. In recent years, lactylation has been widely studied in cancer, immune diseases, neurological diseases, cardiovascular diseases, metabolic
Gejie Zhao, Jia Zhou, Shutong He, Xiao Fei, Guijie Guo   +4 more
openaire   +2 more sources

Poxvirus Proteomics and Virus-Host Protein Interactions [PDF]

Microbiology and Molecular Biology Reviews, 2009
SUMMARY Studies of the functional proteins encoded by the poxvirus genome provide information about the composition of the virus as well as individual virus-virus protein and virus-host protein interactions, which provides insight into viral pathogenesis and drug discovery.
Kim, Van Vliet, Mohamed R, Mohamed, Leiliang, Zhang, Nancy Yaneth, Villa, Steven J, Werden, Jia, Liu, Grant, McFadden   +6 more
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Transcriptome analysis of infection of the archaeon Sulfolobus solfataricus with Sulfolobus turreted icosahedral virus [PDF]

, 2008
Microarray analysis of infection by Sulfolobus turreted icosahedral virus (STIV) revealed insights into the timing and extent of virus transcription, as well as differential regulation of host genes. Using a microarray containing genes from both the host
Walther, Jasper, Douglas, Trevor, Brumfield, Susan K., Bothner, Brian, Ortmann, Alice C., McInnerney, Kathleen, Young, Mark J., Brouns, Stan J.J., Van De Werken, Harmen J.G.; id_orcid, Van De Oost, John, Van Der Oost, John, Werken, H.J.G., van de, Brumfield, S.K., Douglas, T., Oost, J., van der, Walther, J., Young, M.J., Ortmann, A.C., Brouns, S.J.J., Bothner, B., McInnerney, K.   +20 more
core   +1 more source

The impact of cytomegalovirus coinfection on tuberculosis in the mouse model

BMC Infectious Diseases
Background Tuberculosis (TB) remains a major global health challenge, with 10.6 million new cases and 1.3 million deaths annually. HIV coinfection is a well-known risk factor in high-burden regions, but emerging evidence suggests that other viral ...
Jaqueline Marschner, Sebastian Marwitz, Lars Eggers, Linda von Borstel, Lara Buer, David Hertz, Torsten Goldmann, Eleonore Ostermann, Wolfram Brune, Bianca E. Schneider   +9 more
doaj   +1 more source

Mosquito Saliva Subunit Vaccine Enhances Efficacy of VLP Vaccines Against Zika and Chikungunya Viruses

Vaccines
Background/Objectives: Mosquito-borne viruses cause substantial global morbidity and mortality. Mosquito saliva, secreted during biting, facilitates blood feeding and can enhance virus infection.
Siân Jossi, Megan Cole, Yonca Keskek Turk, Sam Verwimp, Katrien Trappeniers, James Luk, Joshua X. D. Ang, Luke Alphey, Leen Delang, Clive S. McKimmie, Olga Pleguezuelos   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A high-throughput yeast two-hybrid protocol to determine virus-host protein interactions

, 2022
S.1-15The yeast two-hybrid (Y2H) system is a powerful method to identify and analyze binary protein interactions. In the field of virology, the Y2H system has significantly increased our knowledge of structure and function of viral proteins by ...
Bailer, S., Koegl, M., Striebinger, H.
core   +1 more source

Sand fly saliva reprograms skin fibroblasts to enhance arbovirus infection

iScience
Summary: Arbovirus transmission by sand flies is a growing public health concern, yet the early skin events shaping infection outcomes remain undefined.
Yonca Keskek Turk, Ailish McCafferty-Brown, Liam Barningham, Magdalena Jancarova, Petr Volf, Matthew E. Rogers, Akira J.T. Alexander, Çağdaş Kaya, Sandy MacDonald, Maria Grazia Cusi, Alain Kohl, Kave Shams, Clive S. McKimmie   +12 more
doaj   +1 more source

Early Virus–Host Cell Interactions

Journal of Molecular Biology, 2018
International ...
openaire   +4 more sources