Results 101 to 110 of about 722,631 (394)

Bacterial superglue enables easy development of efficient virus-like particle based vaccines

Journal of Nanobiotechnology, 2016
BackgroundVirus-like particles (VLPs) represent a significant advance in the development of subunit vaccines, combining high safety and efficacy. Their particulate nature and dense repetitive subunit organization makes them ideal scaffolds for display of
S. Thrane, C. Janitzek, S. Matondo, M. Resende, T. Gustavsson, W. A. de Jongh, Stine B. Clemmensen, W. Roeffen, M. van de Vegte-Bolmer, G. van Gemert, R. Sauerwein, J. Schiller, M. Nielsen, T. Theander, A. Salanti, A. Sander   +15 more
semanticscholar   +1 more source

Platforms, advances, and technical challenges in virus-like particles-based vaccines

Frontiers in Immunology, 2023
Viral infectious diseases threaten human health and global stability. Several vaccine platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based vaccines have been developed to counter these viral infectious diseases.
Reeshu Gupta, K. Arora, Sourav Roy, A. Joseph, Ruchir Rastogi, N. M. Arora, P. Kundu   +6 more
semanticscholar   +1 more source

Virus-like particles as nanovaccine candidates [PDF]

Advances in Natural Sciences: Nanoscience and Nanotechnology, 2013
The existing vaccines are mainly limited to the microorganisms we are able to culture and produce and/or to those whose killing is mediated by humoral response (antibody mediated). It has been more difficult to develop vaccines capable of inducing a functional cellular response needed to prevent or cure chronic diseases.
Gerardo Guillén, Julio Aguilar, Santiago Dueñas, Lisset Hermida, Enrique V. Iglesias, E Penton, Yadira Lobaina, María C. López, Alexis Mussachio, Viviana Falcón, L Alvarez, Gillian Martínez, Lázaro Gil, Iris Valdés, Alienys Izquierdo, Laura Lazo, Ernesto Marcos, Guadalupe Guzmán, Verena Muzio, Luis Gabriel González Herrera   +19 more
openaire   +1 more source

Mucus Physically Restricts Influenza A Viral Particle Access to the Epithelium

Advanced Biology, EarlyView.
The infectious potential of respiratory viruses depends on their ability to navigate through a layer of mucus that serves as a protective barrier in the lung. It is demonstrated that influenza A virus penetration through mucus is significantly limited by the gel's internal microstructure and, to a lesser extent, by adhesive binding to mucin glycans ...
Logan Kaler, Elizabeth M. Engle, Maria Corkran, Ethan Iverson, Allison Boboltz, Maxinne A. Ignacio, Taj Yeruva, Margaret A. Scull, Gregg A. Duncan   +8 more
wiley   +1 more source

RNA Phage VLP-Based Vaccine Platforms

Pharmaceuticals, 2021
Virus-like particles from a variety of RNA bacteriophages have turned out to be useful platforms for delivery of vaccine antigens in a highly immunogenic format.
David S. Peabody, Julianne Peabody, Steven B. Bradfute, Bryce Chackerian   +3 more
doaj   +1 more source

Faddeev description of two-hole one-particle motion and the single-particle spectral function [PDF]

Phys.Rev. C63 (2001) 034313, 2000
The Faddeev technique is employed to address the problem of describing the influence of both particle-particle and particle-hole phonons on the single-particle self-energy. The scope of the few-body Faddeev equations is extended to describe the motion of two-hole one-particle (two-particle one-hole) excitations.
arxiv   +1 more source

Sortase-Mediated Ligation as a Modular Approach for the Covalent Attachment of Proteins to the Exterior of the Bacteriophage P22 Virus-like Particle.

Bioconjugate chemistry, 2017
Virus-like particles are unique platforms well suited for the construction of nanomaterials with broad-range applications. The research presented here describes the development of a modular approach for the covalent attachment of protein domains to the ...
Dustin P Patterson, B. Schwarz, John Avera, B. Western, M. Hicks, P. Krugler, Matthew Terra, M. Uchida, Kimberly McCoy, T. Douglas   +9 more
semanticscholar   +1 more source

Addition of retinoic acid-inducible gene 1 to Ebola virus-like particles to enhance virus-like particle vaccines [PDF]

, 2022
The long-term goal of this study is to investigate if human monocytes treated with Ebola virus (EBOV) virus-like particles (VLPs) supplemented with a constitutively active form of retinoic acid-inducible gene 1 (caRIG-I) induce an inflammatory response ...
Pautz, Elizabeth
core   +1 more source

Generation of Advanced Blood–Brain Barrier Spheroids Using Human‐Induced Pluripotent Stem Cell‐Derived Brain Capillary Endothelial‐Like Cells

Advanced Biology, EarlyView.
In this article, the establishment and characterization of a self‐assembled 3D BBB spheroid model using human induced pluripotent stem cell (hiPSC)‐derived and primary cells is reported. Spheroids demonstrate in‐vivo like tight junction ultrastructure and, in comparison to 2D mono‐cultures, higher transcript expression of BBB specific genes.
Sanjana Mathew‐Schmitt, Sabrina Oerter, Evelin Reitenbach, Sabine Gätzner, Alevtina Höchner, Heinz‐Georg Jahnke, Jörg Piontek, Winfried Neuhaus, Andreas Brachner, Marco Metzger, Antje Appelt‐Menzel   +10 more
wiley   +1 more source

Predicting the impact of particle-particle collisions on turbophoresis with a reduced number of computational particles [PDF]

arXiv, 2019
A common feature of wall-bounded turbulent particle-laden flows is enhanced particle concentrations in a thin layer near the wall due to a phenomenon known as turbophoresis. Even at relatively low bulk volume fractions, particle-particle collisions regulate turbophoresis in a critical way, making simulations sensitive to collisional effects. Lagrangian
arxiv