Results 121 to 130 of about 722,631 (394)

Robust Systemic and Mucosal Immune Responses to Coxsackievirus B3 Elicited by Spider Silk Protein Based Nanovaccines via Subcutaneous Immunization

Advanced Functional Materials, EarlyView.
Spider minor ampullate silk protein (MiSp) and retinoic acid (RA) based nanovaccine are capable of eliciting both mucosal and systemic immune responses following subcutaneous administration and demonstrate significant protective effects against CVB3 infection in mice.
Xingmei Qi, Guoqiang Wei, Yanan Li, Sidong Xiong, Gefei Chen   +4 more
wiley   +1 more source

Incorporation of membrane-anchored flagellin or Escherichia coli heat-labile enterotoxin B subunit enhances the immunogenicity of rabies virus-like particles in mice and dogs

Frontiers in Microbiology, 2015
Rabies remains an important worldwide public health threat, so safe, effective and affordable vaccines are still being sought. Virus-like particle (VLP)-based vaccines targeting various viral pathogens have been successfully produced, licensed and ...
Yinglin eQi, Yinglin eQi, Hongtao eKang, Hongtao eKang, Xuexing eZheng, Hualei eWang, Yuwei eGao, Songtao eYang, Xianzhu eXia   +8 more
doaj   +1 more source

Progress in developing virus-like particle influenza vaccines

Expert Review of Vaccines, 2016
Recombinant vaccines based on virus-like particles (VLPs) or nanoparticles have been successful in their safety and efficacy in preclinical and clinical studies.
F. Quan, Young‐Tae Lee, Ki-hye Kim, Min-chul Kim, Sang-Moo Kang   +4 more
semanticscholar   +1 more source

Cloning and expression of a Saccharomyces cerevisiae RNA-dependent RNA polymerase [PDF]

, 2019
RNA-dependent RNA polymerases (RdRp) are ubiquous enzimes  first described in RNA viruses and virus-like elements. In Saccharomyces cerevisiae this enzyme can be found, fused with capsid proteins, encoded by the L-A helper virus-like particle ...
Garzón, A, Jiménez, J, Mariscal, M, Quintero, J   +3 more
core   +1 more source

At-line multi-angle light scattering detector for faster process development in enveloped virus-like particle purification [PDF]

, 2019
At-line static light scattering and fluorescence monitoring allows direct in-process tracking of fluorescent virus-like particles. We have demonstrated this by coupling at-line multi-angle light scattering and fluorescence detectors to the downstream ...
Cervera, Laura, González-Domínguez, Irene, Gòdia Casablancas, Francesc, Jungbauer, Alois, Pereira Aguilar, P., Schneider, Tobias Amadeus   +5 more
core   +1 more source

Biomimetic Spider Silk by Crosslinking and Functionalization with Multiarm Polyethylene Glycol

Advanced Functional Materials, EarlyView.
Bioconjugation of recombinant mini‐spidroins with multiarm polyethylene glycol (PEG) is employed to produce artificial spider silk, which can be crosslinked and chemically functionalized while maintaining a biomimetic spinning approach. The best fibers exhibit enhanced tensile strength and/or extensibility, both contributing to an increased toughness ...
Viktors Romaņuks, Jēkabs Fridmanis, Benjamin Schmuck, Anna Līna Bula, Alons Lends, Kristine Senkane, Gundars Leitis, Sergejs Gaidukovs, Krisjanis Smits, Anna Rising, Gints Smits, Kristaps Jaudzems   +11 more
wiley   +1 more source

Whole-Inactivated and Virus-Like Particle Vaccine Strategies for Chikungunya Virus.

Journal of Infectious Diseases, 2016
Chikungunya virus (CHIKV) is a global public health threat, having been identified in >60 countries in Asia, Africa, Europe, and the Americas. There is no cure for or licensed vaccine against CHIKV infection. Initial attempts at CHIKV vaccine development
A. DeZure, N. Berkowitz, B. Graham, J. Ledgerwood   +3 more
semanticscholar   +1 more source

The role of influenza neuraminidase transmembrane domain on budding and virus morphology [PDF]

, 2014
Influenza A virus neuraminidase (NA), a type II transmembrane glycoprotein plays a role in the cleavage of sialic acids and facilitating the release of mature virions from the surface of infected cells. NA has also previously been shown to play a role in
Roddy, Scott, Edward
core  

Direct Ink Writing of Conductive Hydrogels

Advanced Functional Materials, EarlyView.
This review examines the use of direct ink writing (DIW) for fabricating conductive hydrogels with customizable 3D structures. It outlines the rheological requirements for successful DIW, followed by an exploration of the materials and ink formulations used to impart electronic and/or ionic conductivity to hydrogels while maintaining printability ...
Monica Ho, Aline Braz Ramirez, Negar Akbarnia, Eric Croiset, Elisabeth Prince, Gerald G. Fuller, Milad Kamkar   +6 more
wiley   +1 more source

Peridynamics-based discrete element method (PeriDEM) model of granular systems involving breakage of arbitrarily shaped particles [PDF]

arXiv, 2020
Usage, manipulation, transport, delivery, and mixing of granular or particulate media, comprised of spherical or polyhedral particles, is commonly encountered in industrial sectors of construction (cement and rock fragments), pharmaceutics (tablets), and transportation (ballast).
arxiv