Results 91 to 100 of about 296,086 (304)

The Case of a 40‐Year‐Old Man With New‐Onset Status Epilepticus in the Setting of HIV Infection

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 40‐year‐old man from Andhra Pradesh in India, while on regular antiretroviral treatment (ART) for long‐standing HIV infection presented with a 1‐day history of new‐onset status epilepticus. CT and MRI brain showed multifocal cerebral ring lesions, some of which demonstrated characteristic ‘hole‐with‐a‐dot’ sign.
Vadde Akhil, Ramachandiran Nandhagopal
wiley   +1 more source

Recombinant modified vaccinia virus Ankara generating Ebola virus-like particles [PDF]

, 2017
There are currently no approved therapeutics or vaccines to treat or protect against the severe hemorrhagic fever and death caused by Ebola virus (EBOV). Ebola virus-like particles (EBOV VLPs) consisting of the matrix protein VP40, the glycoprotein (GP),
Wolferstätter, Michael, Gert Zimmer, Mark Suter, Michael Wolferstätter, Zimmer, Gert, Steigerwald, Robin, Suter, Mark, Hubertus Hochrein, Andrea S. Laimbacher, Marieken Klingenberg, Robin Steigerwald, Chaplin, Paul, Marc Schweneker, Klingenberg, Marieken, Paul Chaplin, Lauterbach, Henning, Hochrein, Hubertus, Laimbacher, Andrea S, Elisabeth M. Schraner, Schraner, Elisabeth M, Wagner, Susanne, Jürgen Hausmann, Hausmann, Jürgen, Susanne Wagner, Schweneker, Marc, Henning Lauterbach, Ulrike Dirmeier, Dirmeier, Ulrike   +27 more
core   +1 more source

Special Issue "Virus-Like Particle Vaccines". [PDF]

, 2020
Virus-like particles (VLPs) have become a key tool for vaccine developers and manufacturers [...
Bachmann, Martin F., Vogel, Monique, Monique Vogel, Martin F. Bachmann   +3 more
core   +1 more source

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source

Self-Assembled Virus-Like Particles from Rotavirus Structural Protein VP6 for Targeted Drug Delivery [PDF]

, 2011
Proteins of viral capsid may self-assemble into virus-like particles (VLPs) that can find many biomedical applications such as platform for drug delivery.
Zhang, JP (张锦平), Zhao, QH (赵庆欢), Zhang, LM (张立明), Zhang, ZJ (张智军), Chen, WH (陈卫红), Qinghuan Zhao, Yuanding Chen, Liming Zhang, Jinping Zhang, Zhijun Zhang, Chen, YD, Weihong Chen   +11 more
core   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Octahedral small virus-like particles of dengue virus type 2

Journal of Virology
Flavivirus envelope (E) and precursor M (prM) proteins, when ectopically expressed, assemble into empty, virus-like particles (VLPs). Cleavage of prM to M and loss of the pr fragment converts the VLPs from immature to mature particles, mimicking a ...
Adam Johnson, Martín Dodes Traian, Richard M. Walsh, Simon Jenni, Stephen C. Harrison   +4 more
doaj   +1 more source

Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Advanced Functional Materials, EarlyView.
This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor, Paula T. Hammond   +4 more
wiley   +1 more source

Development of Virus-like Particle Plant-Based Vaccines against Avian H5 and H9 Influenza A Viruses [PDF]

Avian influenza A virus (AIV) is a significant cause of mortality in poultry, causing substantial economic loss, particularly in developing countries, and has zoonotic potential.
Iqbal, Munir, Dunham, Stephen P., Elbohy, Ola A, Janet M. Daly, Stephen P. Dunham, Daly, Janet M., Munir Iqbal, Dunham, Stephen P, Elbohy, Ola A., Daly, Janet M, Ola A. Elbohy   +10 more
core   +2 more sources

Establishment of a reverse genetics system for Schmallenberg virus, a newly emerged orthobunyavirus in Europe [PDF]

, 2013
Schmallenberg virus (SBV) is a newly emerged orthobunyavirus that has caused widespread disease in cattle, sheep and goats in Europe. Like other orthobunyaviruses, SBV is characterized by a tripartite negative-sense RNA genome that encodes four ...
Szemiel, A.M., McLees, A., Li, P., van Knippenberg, I.C., McLees, Angela, Li, Ping, Shi, X., van Knippenberg, Ingeborg C., Elliott, Richard M., Szemiel, Agnieszka M., Shi, Xiaohong, Koudriakova, E., Koudriakova, Elina, Blakqori, G., Elliott, R.M., Blakqori, Gjon   +15 more
core   +1 more source