Results 101 to 110 of about 6,611,706 (299)

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Development of Virus-like Particle Plant-Based Vaccines against Avian H5 and H9 Influenza A Viruses [PDF]

Avian influenza A virus (AIV) is a significant cause of mortality in poultry, causing substantial economic loss, particularly in developing countries, and has zoonotic potential.
Iqbal, Munir, Dunham, Stephen P., Elbohy, Ola A, Janet M. Daly, Stephen P. Dunham, Daly, Janet M., Munir Iqbal, Dunham, Stephen P, Elbohy, Ola A., Daly, Janet M, Ola A. Elbohy   +10 more
core   +1 more source

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

Recombinant modified vaccinia virus Ankara generating Ebola virus-like particles [PDF]

, 2017
There are currently no approved therapeutics or vaccines to treat or protect against the severe hemorrhagic fever and death caused by Ebola virus (EBOV). Ebola virus-like particles (EBOV VLPs) consisting of the matrix protein VP40, the glycoprotein (GP),
Wolferstätter, Michael, Gert Zimmer, Mark Suter, Michael Wolferstätter, Zimmer, Gert, Steigerwald, Robin, Suter, Mark, Hubertus Hochrein, Andrea S. Laimbacher, Marieken Klingenberg, Robin Steigerwald, Chaplin, Paul, Marc Schweneker, Klingenberg, Marieken, Paul Chaplin, Lauterbach, Henning, Hochrein, Hubertus, Laimbacher, Andrea S, Elisabeth M. Schraner, Schraner, Elisabeth M, Wagner, Susanne, Jürgen Hausmann, Hausmann, Jürgen, Susanne Wagner, Schweneker, Marc, Henning Lauterbach, Ulrike Dirmeier, Dirmeier, Ulrike   +27 more
core   +2 more sources

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Dynamics of HIV-1 assembly and release. [PDF]

, 2009
Assembly and release of human immunodeficiency virus (HIV) occur at the plasma membrane of infected cells and are driven by the Gag polyprotein. Previous studies analyzed viral morphogenesis using biochemical methods and static images, while dynamic and ...
Kräusslich Hans-Georg, Barbara Müller, William J. Godinez, Bräuchle Christoph, Müller, Barbara, Rohr Karl, Karl Rohr, Godinez, William J., William J Godinez, Lampe Marko, Eils, Roland, Godinez William J., Roland Eils, Rohr, Karl, Lampe, Marko, Ivanchenko Sergey, Lamb, Don C., Don C. Lamb, Marko Lampe, Bräuchle, Christoph, Eils Roland, Lamb Don C., Hans-Georg Kräusslich, Christoph Bräuchle, Kräusslich, Hans-Georg, Sergey Ivanchenko, Ivanchenko, Sergey, Don C Lamb, Müller Barbara   +28 more
core   +2 more sources

Programmable Functional Silicification of DNA Origami Nanostructures

Advanced Materials, EarlyView.
This work introduces additional functionality into silica‐coated DNA origami nanostructures using non‐standard silica precursors. A fluorescent precursor enables enhanced intracellular tracking, while a disulfide‐containing reagent yields redox‐responsive, degradable silica coatings.
Anna V. Baptist, Lasse Guericke, Philipp Mauker, Oliver Thorn‐Seshold, Amelie Heuer‐Jungemann   +4 more
wiley   +1 more source

Plant production and immunogenic characterisation of Human papillomavirus chimaeric vaccines [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 153-175).Cervical cancer is primarily caused by infection with Human papillomavirus (HPV) and is a global concern, particularly in developing countries which contain ~80% of the cervical ...
Pineo, Catherine
core   +1 more source

Artificial Intelligence Meets Micro/Nanorobotics

Advanced Materials, EarlyView.
Artificial intelligence is transforming micro‐ and nanorobots from externally controlled, task‐specific machines into adaptive, autonomous systems. Machine learning, multimodal perception, digital twins, AI‐guided materials and geometry design enhance propulsion, localization, decision‐making, whichaccelerates clinical and environmental applications ...
Fatma M. Yurtsever, Minitha Cherukutty Ramakrishnan, Ian Kuula Ross, Ivan Zelinka, Hamed Shahsavan, Michal Otyepka, Martin Pumera   +6 more
wiley   +1 more source