Results 121 to 130 of about 6,611,706 (299)
Modular Virus-Like Particles: Building Nanoscale Platforms for Multiple Applications
Postępy MikrobiologiiVirus-like particles (VLPs) are multiprotein structures that mimic the conformation of infectious virus particles and are therefore potent inducers of immune responses in mammals.
Naskalska Antonina
doaj +1 more source
PLoS ONE, 2017 Light microscopy is a powerful tool in the detection and analysis of parasites, fungi, and prokaryotes, but has been challenging to use for the detection of individual virus particles.
George G Daaboul +11 more
doaj +1 more source
RNA transmission and expression from inert HIV candidate vaccine virus-like-particles [PDF]
, 2008 Includes abstract.Includes bibliographical references (leaves 136-158).HIV-1 Gag virus-like-particles (VLPs) produced in various expression systems are potent stimulators of both cellular and humoral immune responses in animal models.
Valley-Omar, Ziyaad
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Advanced Science, EarlyView.Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu +13 more
wiley +1 more source
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
Potato leafroll virus, its purification from its vector Myzus persicae [PDF]
, 1967 Experiments were described on the purification of potato leafroll virus (PLRV) from its vector Myzus persicae. Preliminary experiments demonstrated that much non- viral material had to be removed from aphid macerates to obtain a pure virus preparation ...
Peters, D.
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Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
RNA packaging and uncoating in simple single-stranded RNA viruses [PDF]
, 2012 Simple (non-enveloped) small, positive-sense single-stranded RNA viruses infect hosts from all kingdoms of life. However, their assembly and uncoating processes remain poorly understood. For turnip crinkle virus (TCV), 3D reconstructions by cryoelectron
Bakker, Saskia
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Silica Nanoparticles as a Carrier of Virus-Like Particles for Hepatitis B Vaccine
Adherence of hepatitis B virus like particles to silica (SiO2) nanoparticles was explored for immunomodulation purposes by optical absorbance measurements, transmission electron microscopy, fluorescence microscopy and vaccination of Balb/c mice.
Skrastiņa, Dace +6 more
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