Results 61 to 70 of about 6,229,730 (383)

Bat and virus [PDF]

Protein & Cell, 2010
Bat, the only flying mammal and count more than 20% of the extant mammals on earth, were recently identified as a natural reservoir of emerging and reemerging infectious pathogens. Astonishing amount (more than 70) and genetic diversity of viruses isolated from the bat have been identified in different populations throughout the world.
openaire   +3 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies [PDF]

, 2016
There is mounting evidence that in the absence of neutralizing antibodies cross-reactive T cells provide protection against pandemic influenza viruses. Here, we compared protection and CD8+ T cell responses following challenge with H1N1 2009 pandemic and
Callewaert, Nico, Fiers, Walter, Saelens, Xavier, Schepens, Bert, Schotsaert, Michael, Smet, Anouk, Stegalkina, Svetlana, Vanderschaeghe, Dieter, Vogel, Thorsten U, Ysenbaert, Tine   +9 more
core   +2 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Epidemiology and biology of a herpesvirus in rabies endemic vampire bat populations

Nature Communications, 2020
Here, Griffiths et al. show infection of 80–100% of sampled vampire bats in Peru with a newly discovered betaherpesvirus (DrBHV) that exhibits specificity within neotropical bats and evidence for superinfection.
Megan E. Griffiths, Laura M. Bergner, Alice Broos, Diana K. Meza, Ana da Silva Filipe, Andrew Davison, Carlos Tello, Daniel J. Becker, Daniel G. Streicker   +8 more
doaj   +1 more source

Investigating the etiology of acute febrile illness: a prospective clinic-based study in Uganda

BMC Infectious Diseases, 2023
Background Historically, malaria has been the predominant cause of acute febrile illness (AFI) in sub-Saharan Africa. However, during the last two decades, malaria incidence has declined due to concerted public health control efforts, including the ...
Brian K. Kigozi, Grishma A. Kharod, Henry Bukenya, Sean V. Shadomy, Dana L. Haberling, Robyn A. Stoddard, Renee L. Galloway, Phionah Tushabe, Annet Nankya, Thomas Nsibambi, Edward Katongole Mbidde, Julius J. Lutwama, Jamie L. Perniciaro, William L. Nicholson, William A. Bower, Josephine Bwogi, David D. Blaney   +16 more
doaj   +1 more source

Cellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120 [PDF]

, 2001
BACKGROUND: Cellulose acetate phthalate (CAP), a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the human immunodeficiency virus type 1 (HIV-1) and several herpesviruses. CAP formulations
A Boyum, A Robert Neurath, A Trkola, A Trkola, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, Asim K Debnath, CD Rizzuto, CK Lapham, CM Javan, DR Burton, DR Littman, EA Berger, F Cocchi, G Alkhatib, H Choe, H Deng, J Bilello, JA Este, JC Lee, K Javaherian, KH Manson, L Wu, L Xiao, M Baba, M Baba, M Moulard, M Thali, MA Skinner, MC Peitsch, Nathan Strick, P Greenhead, PD Kwong, RA Anderson, RA Maguire, RF Speck, RJ Shattock, S Harada, S Laal, S Matsushita, S Rusconi, S Shaunak, T Dragic, T Gyotoku, T Kawamura, T Muster, TN Hart, WR Melander, Y Feng, YI Rumyantseva, Yun-Yao Li   +55 more
core   +3 more sources

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Arboviruses and symbiotic viruses cooperatively hijack insect sperm-specific proteins for paternal transmission

Nature Communications, 2023
Arboviruses and symbiotic viruses can be paternally transmitted by male insects to their offspring, but the mechanism remains largely unknown. Here, the authors identify the sperm-specific serpin protein HongrES1 of the leafhopper Recilia dorsalis as a ...
Jiajia Wan, Qifu Liang, Ruonan Zhang, Yu Cheng, Xin Wang, Hui Wang, Jieting Zhang, Dongsheng Jia, Yu Du, Wenhui Zheng, Dingzhong Tang, Taiyun Wei, Qian Chen   +12 more
doaj   +1 more source

The Brazilian Zika virus strain causes birth defects in experimental models

Nature, 2016
Zika virus infection has been linked to an increase in the number of infants born with microcephaly in Brazil, but direct experimental proof that Zika virus causes birth defects was lacking. Here Alysson Muotri and colleagues show that the Brazilian Zika
Fernanda R. Cugola, I. Fernandes, F. B. Russo, Beatriz C. Freitas, João Leonardo Rodrigues Mendonça Dias, Katia P. Guimarães, C. Benazzato, N. Almeida, G. C. Pignatari, Sarah Romero, C. M. Polonio, I. Cunha, C. L. Freitas, W. Brandão, C. Rossato, David A G Andrade, D. Faria, A. T. Garcez, Carlos Alberto Buchpigel, C. Braconi, E. Mendes, A. Sall, P. Zanotto, J. Peron, A. Muotri, Patricia C B Beltrão-Braga   +25 more
semanticscholar   +1 more source