Results 61 to 70 of about 4,195,312 (308)
Transition between immune and disease states in a cellular automaton model of clonal immune response
, 1997 In this paper we extend the Celada-Seiden (CS) model of the humoral immune response to include infectious virus and cytotoxic T lymphocytes (cellular response).
Abbas +26 more
core +2 more sources
A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis [PDF]
, 2017 The structural flexibility or 'breathing' of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium.
Diamond, Michael S +4 more
core +5 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Potential and limitations of plant virus epidemiology: lessons from the Potato virus Y pathosystem [PDF]
, 2011 Plant virus epidemiology provides powerful tools to investigate key factors that contribute to virus epidemics in agricultural crops. When successful, epidemiological approaches help to guide decisions regarding plant protection strategies.
Döring, Thomas F.
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Emergence of measles virus genotype D8 amidst endemic B3 circulation in Uganda, 2023-2025
International Journal of Infectious DiseasesObjectives: Measles remains a significant global health threat, with recurrent outbreaks, even in regions such as America, where the disease had been eliminated.
Prossy Namuwulya +18 more
doaj +1 more source
Effect of Coated Silver Nanoparticles on Cancerous vs. Healthy Cells
Journal of Toxicology, 2022 Unique properties of silver nanoparticles (NPs) ensure their wide applications, in biomedicine; for this reason, it is very important carefully to study the toxicity of such NPs. The influence of silver nanoparticles coated with natural resin (Ag NPs) on
Liubov Artiukh +4 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Nature CommunicationsViruses associated with acute febrile illness in Africa cause a spectrum of clinical disease from mild to life-threatening. Routine diagnostic methods are insufficient to identify all viral pathogens in this region.
Shirin Ashraf +26 more
doaj +1 more source
mBio, 2014 Most of the circulating vaccine-derived polioviruses (cVDPVs) implicated in poliomyelitis outbreaks in Madagascar have been shown to be recombinants between the type 2 poliovirus (PV) strain of the oral polio vaccine (Sabin 2) and another species C human
Barbara Holmblat +5 more
doaj +1 more source