Results 81 to 90 of about 4,225,102 (309)

Optimal Control to Limit the Propagation Effect of a Virus Outbreak on a Network [PDF]

open access: yes, 2019
The aim of this paper is to propose an optimal control strategy to face the propagation effects of a virus outbreak on a network; a recently proposed model is integrated and analysed.
Di Giamberardino, Paolo   +1 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Immunological and virological characterization of HIV-1 viremia controllers in the North Region of Brazil

open access: yesBMC Infectious Diseases, 2017
Background A rare phenotype of clinical non-progressors to AIDS is not well understood and the new protocol for universal treatment, may block the understanding of viral control thus it is crucial to define this controversial group.
Samara Tatielle M. Gomes   +9 more
doaj   +1 more source

A study on the isolation of leukemia virus of AKR mouse by fluorocarbon [PDF]

open access: yes, 1962
The authors have succeeded in isolating a biologically-active leukemia virus from leukemic tissues of AKR mice with a fluorocarbon. From the chemical analysis of the biologically-active virus fraction it has been clarified that the AKR leukemia virus is ...
Miyoshi, Isao, Okada, Koichi
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system. [PDF]

open access: yes, 1992
Following intracerebral inoculation of adult Balb/c Byj mice, the MHV-4 strain of mouse hepatitis virus (MHV) had an LD50 of less than 0.1 PFU, whereas its monoclonal antibody resistant variant V5A13.1 had an LD50 of 10(4.2) PFU.
Bloom, F   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts

open access: yesNature Communications
Bunyavirales is a very large order including viruses infecting a variety of taxonomic groups such as arthropods, vertebrates, plants, and protozoa. Some bunyaviruses are transmitted between vertebrate hosts by blood-sucking arthropods and cause major ...
Selim Terhzaz   +9 more
doaj   +1 more source

Advancing Arbovirus Research in the Caribbean and Latin America: 2025 Global Virus Network Regional Meeting

open access: yesViruses
A May 2025 symposium convened leading virology experts across Latin America and the Caribbean (LAC) to advance regional research and collaborative efforts.
Tiffany R. Butterfield   +5 more
doaj   +1 more source

Genetic Methods to Identify and Manipulate Newly born Neurons in the Adult Brain

open access: yesFrontiers in Neuroscience, 2011
Although mammalian neurogenesis is mostly completed by the perinatal period, new neurons are continuously generated in the subventricular zone of the lateral ventricle and the subgranular zone of the hippocampal dentate gyrus.
Itaru eImayoshi   +2 more
doaj   +1 more source

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