Results 61 to 70 of about 2,988,144 (307)

Vaccinia Virus Infection Requires Maturation of Macropinosomes. [PDF]

, 2015
The prototypic poxvirus, vaccinia virus (VACV), occurs in two infectious forms, mature virions (MVs) and extracellular virions (EVs). Both enter HeLa cells by inducing macropinocytic uptake.
Mercer, Jason, Rizopoulos, Zaira, Balistreri, G, Kilcher, S, Mercer, J, Syedbasha, M, Kilcher, Samuel, Helenius, Ari, Balistreri, Giuseppe, Rizopoulos, Z, Syedbasha, Mohammedyaseen, Martin, Caroline K., Martin, CK, Helenius, A   +13 more
core   +1 more source

Transcriptome Dynamics in Triticum aestivum Genotypes Associated with Resistance against the Wheat Dwarf Virus

Viruses, 2023
Wheat dwarf virus (WDV) is one of the most important pathogens of cereal crops worldwide. To understand the molecular mechanism of resistance, here we investigated the comparative transcriptome of wheat genotypes with different levels of resistance ...
Abdoallah Sharaf, Przemysław Nuc, Jan Ripl, Glenda Alquicer, Emad Ibrahim, Xifeng Wang, Midatharahally N. Maruthi, Jiban Kumar Kundu   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A significant sex--but not elective cesarean section--effect on mother-to-child transmission of hepatitis C virus infection

, 2005
BACKGROUND: Risk factors for mother-to-child transmission of hepatitis C virus (HCV) are poorly quantified. METHODS: We conducted a European multicenter prospective study of HCV-infected pregnant women and their infants.
LANARI, MARCELLO, European, Paediatric Hepatitis C. Virus Network   +1 more
core   +1 more source

Interferon, virus vaccines and antiviral drugs [PDF]

, 2008
The emergence of viruses with zoonotic potential, i.e. with the potential ability to cross species barriers to infect unnatural hosts, poses a huge threat to humans.
Rodrigues, Ana Mara Lopes
core   +2 more sources

Evaluation of an Engineered Zika Virus-Like Particle Vaccine Candidate in a Mosquito-Mouse Transmission Model

mSphere, 2023
The primary route of Zika virus (ZIKV) transmission is through the bite of an infected Aedes mosquito, when it probes the skin of a vertebrate host during a blood meal.
Maria Vittoria Mancini, Rapeepat Tandavanitj, Thomas H. Ant, Shivan M. Murdochy, Daniel D. Gingell, Chayanee Setthapramote, Piyatida Natsrita, Alain Kohl, Steven P. Sinkins, Arvind H. Patel, Giuditta De Lorenzo   +10 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Emergence of measles virus genotype D8 amidst endemic B3 circulation in Uganda, 2023-2025

International Journal of Infectious Diseases
Objectives: Measles remains a significant global health threat, with recurrent outbreaks, even in regions such as America, where the disease had been eliminated.
Prossy Namuwulya, Irene Turyahabwe, Rena Nakyeyune, Molly Birungi, Phionah Tushabe, James Peter Eliku, Francis Aine, Jonathan Comfort Haumba, Mathias Ssenono, Lucy Nakabazzi, Maria Nabbuto, Jacob Mpiima, Micheal Baganizi, Immaculate Ampeire, Annet Kisakye, Qouilazoni Aquino Ukuli, Henry Bukenya, Josephine Bwogi, Barnabas Bakamutumaho   +18 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source