Results 61 to 70 of about 4,225,102 (309)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis [PDF]

, 2017
The structural flexibility or 'breathing' of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium.
Diamond, Michael S, Dowd, Kimberly A, Goo, Leslie, Pierson, Theodore C, VanBlargan, Laura A   +4 more
core   +5 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Emergence of measles virus genotype D8 amidst endemic B3 circulation in Uganda, 2023-2025

International Journal of Infectious Diseases
Objectives: Measles remains a significant global health threat, with recurrent outbreaks, even in regions such as America, where the disease had been eliminated.
Prossy Namuwulya, Irene Turyahabwe, Rena Nakyeyune, Molly Birungi, Phionah Tushabe, James Peter Eliku, Francis Aine, Jonathan Comfort Haumba, Mathias Ssenono, Lucy Nakabazzi, Maria Nabbuto, Jacob Mpiima, Micheal Baganizi, Immaculate Ampeire, Annet Kisakye, Qouilazoni Aquino Ukuli, Henry Bukenya, Josephine Bwogi, Barnabas Bakamutumaho   +18 more
doaj   +1 more source

Effect of Coated Silver Nanoparticles on Cancerous vs. Healthy Cells

Journal of Toxicology, 2022
Unique properties of silver nanoparticles (NPs) ensure their wide applications, in biomedicine; for this reason, it is very important carefully to study the toxicity of such NPs. The influence of silver nanoparticles coated with natural resin (Ag NPs) on
Liubov Artiukh, Olga Povnitsa, Svitlana Zahorodnia, Calin V. Pop, Nodari Rizun   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Uncovering the viral aetiology of undiagnosed acute febrile illness in Uganda using metagenomic sequencing

Nature Communications
Viruses associated with acute febrile illness in Africa cause a spectrum of clinical disease from mild to life-threatening. Routine diagnostic methods are insufficient to identify all viral pathogens in this region.
Shirin Ashraf, Hanna Jerome, Daniel Lule Bugembe, Deogratius Ssemwanga, Timothy Byaruhanga, John Timothy Kayiwa, Robert Downing, Jesus F. Salazar-Gonzalez, Maria G. Salazar, James G. Shepherd, Craig Wilkie, Chris Davis, Nicola Logan, Sreenu B. Vattipally, Gavin S. Wilkie, Ana da Silva Filipe, Alfred Ssekagiri, Prossy Namuwulya, Henry Bukenya, Brian K. Kigozi, Weronika Witkowska McConnell, Brian J. Willett, Stephen Balinandi, Julius Lutwama, Pontiano Kaleebu, Josephine Bwogi, Emma C. Thomson   +26 more
doaj   +1 more source

Nonhomologous Recombination between Defective Poliovirus and Coxsackievirus Genomes Suggests a New Model of Genetic Plasticity for Picornaviruses

mBio, 2014
Most of the circulating vaccine-derived polioviruses (cVDPVs) implicated in poliomyelitis outbreaks in Madagascar have been shown to be recombinants between the type 2 poliovirus (PV) strain of the oral polio vaccine (Sabin 2) and another species C human
Barbara Holmblat, Sophie Jégouic, Claire Muslin, Bruno Blondel, Marie-Line Joffret, Francis Delpeyroux   +5 more
doaj   +1 more source

Densovirus induces winged morphs in asexual clones of the rosy apple aphid, Dysaphis plantaginea [PDF]

, 2009
Winged morphs of aphids are essential for their dispersal and survival. We discovered that the production of the winged morph in asexual clones of the rosy apple aphid, Dysaphis plantaginea, is dependent on their infection with a DNA virus, Dysaphis ...
E. V. Ryabov, G. Keane, N. Naish, C. Evered, D. Winstanley, Zera, Braendle, Hodge, Fereres, van Munster, van Munster, Ryabov, Ban, Hales, Fu, Iseki, Barton   +16 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source