Results 51 to 60 of about 3,262,736 (331)
Role of Hepatitis C Virus Envelope Glycoprotein E1 in Virus Entry and Assembly
Frontiers in Immunology, 2018 Hepatitis C virus (HCV) glycoproteins E1 and E2 form a heterodimer to constitute viral envelope proteins, which play an essential role in virus entry. E1 does not directly interact with host receptors, and its functions in viral entry are exerted mostly ...
Yimin Tong +6 more
doaj +1 more source
CryoEM of Viral Ribonucleoproteins and Nucleocapsids of Single-Stranded RNA Viruses
Viruses, 2023 Single-stranded RNA viruses (ssRNAv) are characterized by their biological diversity and great adaptability to different hosts; traits which make them a major threat to human health due to their potential to cause zoonotic outbreaks.
Andrea Modrego +3 more
doaj +1 more source
Bluetongue virus assembly and exit pathways. [PDF]
Adv Virus Res, 2020 Bluetongue virus (BTV) is an insect-vectored emerging pathogen of wild ruminants and livestock in many parts of the world. The virion particle is a complex structure of consecutive layers of protein surrounding a genome of 10 double-stranded (ds) RNA segments. BTV has been studied extensively as a model system for large, nonenveloped dsRNA viruses.
Roy P.
europepmc +3 more sources
Bionanomaterials from plant viruses [PDF]
, 2015 Plant virus capsids have emerged as useful biotemplates for material synthesis. All plant virus capsids are assembled with high-precision, three-dimensional structures providing nanoscale architectures that are highly monodisperse, can be produced in ...
Aljabali, Alaa A. A., Evans, David
core +2 more sources
Genome Research, 2020 Viruses are the most abundant biological entities on Earth and play key roles in host ecology, evolution, and horizontal gene transfer. Despite recent progress in viral metagenomics, the inherent genetic complexity of virus populations still poses ...
J. Beaulaurier +10 more
semanticscholar +1 more source
Biophysica, 2023 Virus particles consist of a protein coat that protects their genetic material and delivers it to the host cell for self-replication. Understanding the interplay between virus structure and function is a requirement for understanding critical processes ...
David Reguera +6 more
doaj +1 more source
Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]
, 2013 Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P. +12 more
core +2 more sources
Capsid protein structure in Zika virus reveals the flavivirus assembly process
Nature Communications, 2020 Structures of flavivirus (dengue virus and Zika virus) particles are known to near-atomic resolution and show detailed structure and arrangement of their surface proteins (E and prM in immature virus or M in mature virus). By contrast, the arrangement of
T. Y. Tan +11 more
semanticscholar +1 more source
In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus. [PDF]
, 2016 Packaging of the genome into a protein capsid and its subsequent delivery into a host cell are two fundamental processes in the life cycle of a virus. Unlike double-stranded DNA viruses, which pump their genome into a preformed capsid, single-stranded ...
Dai, Xinghong +6 more
core +1 more source
Adeno-associated virus capsid assembly is divergent and stochastic
Nature Communications, 2020 Adeno-associated viruses (AAVs) are increasingly used as gene therapy vectors. AAVs package their genome in a non-enveloped T = 1 icosahedral capsid of ~3.8 megaDalton, consisting of 60 subunits of 3 distinct viral proteins (VPs), which vary only in ...
Tobias P. Wörner +7 more
semanticscholar +1 more source