Results 81 to 90 of about 11,567,095 (406)
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
BMC Primary Care, 2023 Background The rate of progression of type 2 diabetes following diagnosis varies across individuals and populations. Studies investigating the progression of type 2 diabetes in adult African populations with newly diagnosed diabetes are limited. We aimed
Davis Kibirige +3 more
doaj +1 more source
Spatial and temporal dynamics of an almost periodic reaction-diffusion system for West Nile virus [PDF]
arXiv, 2020 In current paper, we put forward a reaction-diffusion system for West Nile virus in spatial heterogeneous and time almost periodic environment with free boundaries to investigate the influences of the habitat differences and seasonal variations on the propagation of West Nile virus.
arxiv
Viruses and Virus Diseases of Rubus.
Plant Disease, 2013 Blackberry and raspberry are members of the family Rosaceae. They are classified in the genus Rubus, which comprises hundreds of species and has a center of origin in the Far East.
R. Martin +5 more
semanticscholar +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Human Vaccines & Immunotherapeutics, 2018 Pre-clinical models mimicking persistent hepatitis B virus (HBV) expression are seldom, do not capture all features of a human chronic infection and due to their complexity, are subject to variability.
Roland Kratzer +7 more
doaj +1 more source
Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways
Nature Communications, 2022 The SARS-CoV-2 variant of concern Omicron, has been reported to mainly use the endocytosis pathway for viral entry, bypassing the furin/TMPRSS2 pathway utilised by other variants. Here, the authors test a panel of SARS-CoV-2 variants in TMPRSS2 knock out
Naoko Iwata-Yoshikawa +15 more
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Molecules, 2022 The heterocyclic indole structure has been shown to be one of the most promising scaffolds, offering various medicinal advantages from its wide range of biological activity. Nonetheless, the significance of 3-oxindole has been less known.
Dong-Eun Kim +7 more
doaj +1 more source
Network analysis and disease subnets for the SARS-CoV-2/Human interactome [PDF]
arXiv, 2020 Motivation: With the aim to amplify and make sense of interactions of virus-human proteins in the case of SARS-CoV-2, we performed a structural analysis of the network of protein interactions obtained from the integration of three sources: 1) proteins of virus SARS-CoV-2, 2)physical interactions between SARS-CoV-2 and human proteins, 3) known ...
arxiv