Results 171 to 180 of about 258,080 (265)

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Striking tick-borne virus diversity and potential reservoirs documented during One-Health-based cross-sectional screening in Anatolia. [PDF]

Parasit Vectors
Dinçer E, Timurkan MÖ, Oğuz B, Ozan E, Coşkun N, Kızıltepe Ş, Dinçer PFP, Şahan A, Yalçınkaya D, Gökçeçik ÖF, Nayir MB, Bayendur SH, Bourke BP, Linton YM, Ergunay K.   +14 more
europepmc   +1 more source

Revealing RNA virus diversity and evolution in unicellular algae transcriptomes. [PDF]

Virus Evol, 2021
Charon J, Murray S, Holmes EC.
europepmc   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

RNA virus diversity highlights the potential biosecurity threat posed by Antarctic krill. [PDF]

Mar Life Sci Technol
Xu T, Zhao X, Loch T, Zhu J, Wang W, Wang X, Wang C, Fan G, Hao B, Zhang J, Zhao W, Bondad-Reantaso MG, Alday-Sanz V, Zhang Q.   +13 more
europepmc   +1 more source

Genetic recombination among tomato yellow leaf curl virus isolates in commercial tomato crops in Kuwait drives emergence of virus diversity: a comparative genomic analysis. [PDF]

BMC Res Notes, 2023
Al-Ali E, Al-Hashash H, Akbar A, Al-Aqeel H, Al-Shayji N, Alotaibi M, Ben Hejji A.   +6 more
europepmc   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Virus Diversity and Loads in Crickets Reared for Feed: Implications for Husbandry. [PDF]

Front Vet Sci, 2021
de Miranda JR, Granberg F, Low M, Onorati P, Semberg E, Jansson A, Berggren Å.   +6 more
europepmc   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

The links between dietary diversity and RNA virus diversity harbored by the great evening bat (Ia io). [PDF]

Microbiome
Huang Z, Wang Z, Liu Y, Ke C, Feng J, He B, Jiang T.   +6 more
europepmc   +1 more source