Results 191 to 200 of about 263,373 (311)

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Hungary as a source of West Nile virus diversity and spread in Europe: insights from the 2024 transmission season. [PDF]

Euro Surveill
Nagy A, Erdélyi K, Molnár Z, Lőrincz RB, Nagy O, Koroknai A, Csonka N, Kerényi K, Forgách P, Horváth E, Soltész Z, Nagy G, Takács M, Barcsay E, Szomor K, Tóth GE, Cadar D.   +16 more
europepmc   +1 more source

Reversion of a resistance-breaking mutation shows reversion costs and high virus diversity at necrotic local lesions. [PDF]

Mol Plant Pathol, 2023
Moreno-Pérez MG, Bera S, McLeish M, Fraile A, García-Arenal F.   +4 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Using molecular approaches to assess rabies virus diversity in Haiti and the Dominican Republic. [PDF]

Front Microbiol
Condori RE, Dilius AP, Cadet R, Lopez-Nuñez G, Diaz-Mateo E, Gomez-Belliard AK, Ross YB, Boutelle C, Velasco-Villa A, Gigante CM, Li Y, Wallace RM.   +11 more
europepmc   +1 more source

Virus diversity, wildlife-domestic animal circulation and potential zoonotic viruses of small mammals, pangolins and zoo animals. [PDF]

Nat Commun, 2023
Cui X, Fan K, Liang X, Gong W, Chen W, He B, Chen X, Wang H, Wang X, Zhang P, Lu X, Chen R, Lin K, Liu J, Zhai J, Liu DX, Shan F, Li Y, Chen RA, Meng H, Li X, Mi S, Jiang J, Zhou N, Chen Z, Zou JJ, Ge D, Yang Q, He K, Chen T, Wu YJ, Lu H, Irwin DM, Shen X, Hu Y, Lu X, Ding C, Guan Y, Tu C, Shen Y.   +39 more
europepmc   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Unveiling hepatitis E virus diversity in Sudan's internally displaced populations: a molecular epidemiology approach. [PDF]

Trop Med Health
Osman HA, Bakr WMK, Hashish MH, Elkhidir IM, Bedri S, Oyola SO, Norder H, Abd El-Wahab EW.   +7 more
europepmc   +1 more source

Chirohepevirus from Bats: Insights into Hepatitis E Virus Diversity and Evolution. [PDF]

Viruses, 2022
Wang B, Yang XL.
europepmc   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source