Results 31 to 40 of about 218,144 (258)
Molecular Engineering of Virus Tropism
International Journal of Molecular SciencesEngineered viral vectors designed to deliver genetic material to specific targets offer significant potential for disease treatment, safer vaccine development, and the creation of novel biochemical research tools. Viral tropism, the specificity of a virus for infecting a particular host, is often modified in recombinant viruses to achieve precise ...
Bo He +7 more
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Relative infectivity of the SARS-CoV-2 Omicron variant in human alveolar cells
iScience, 2022 Summary: With the continuous emergence of highly transmissible SARS-CoV-2 variants, the comparison of their infectivity has become a critical issue for public health.
Taewoo Kim +12 more
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Bioengineering, 2022 The unexpected appearance of the monkeypox virus and the extensive geographic dispersal of cases have prompted researchers to concentrate on potential therapeutic approaches.
Muhammad Naveed +11 more
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Manipulation of the mechanical properties of a virus by protein engineering [PDF]
Proceedings of the National Academy of Sciences, 2008 In a previous study, we showed that the DNA molecule within a spherical virus (the minute virus of mice) plays an architectural role by anisotropically increasing the mechanical stiffness of the virus. A finite element model predicted that this mechanical reinforcement is a consequence of the interaction between ...
Carolina, Carrasco +3 more
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Engineered bacteria launch and control an oncolytic virus
Nature Biomedical Engineering, 2023 Abstract The ability of bacteria and viruses to selectively replicate in tumors has led to synthetic engineering of new microbial therapies. Here we design a cooperative strategy whereby S.
Zakary S. Singer +9 more
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Molecular Therapy: OncologyViruses are able to efficiently penetrate cells, multiply, and eventually kill infected cells, release tumor antigens, and activate the immune system. Therefore, viruses are highly attractive novel agents for cancer therapy.
Christina Funk +12 more
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Leveraging Synthetic Virology for the Rapid Engineering of Vesicular Stomatitis Virus (VSV)
VirusesVesicular stomatitis virus (VSV) is a prototype RNA virus that has been instrumental in advancing our understanding of viral molecular biology and has applications in vaccine development, cancer therapy, antiviral screening, and more.
Chad M. Moles +6 more
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A Cancer-Favoring, Engineered Vaccinia Virus for Cholangiocarcinoma [PDF]
Cancers, 2019 While oncolytic vaccinia virus-based therapy has shown promising results for uncured patients with cancer, its effects on cholangiocarcinoma (CCA) remain unclear. Here, we evaluated the anti-cancer activity of the cancer-favoring oncolytic vaccinia virus (CVV), which was recognized as a promising therapy for stem cell-like colon cancer cells (SCCs) and
So Young Yoo +4 more
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Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells
Emerging Microbes and Infections, 2020 Studies on patients with the coronavirus disease-2019 (COVID-19) have implicated that the gastrointestinal (GI) tract is a major site of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Sunhee Lee +4 more
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Identification of HIV transmitting CD11c+ human epidermal dendritic cells
Nature Communications, 2019 Composition and function of immune populations at barrier surfaces is crucial for response to infection. Here, the authors identify a population of dendritic cells in human epidermis, abundant in anogenital epithelia and distinct from Langerhans cells by
Kirstie M. Bertram +28 more
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