Results 91 to 100 of about 298,867 (391)

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas [PDF]

, 2015
Burkitt lymphoma (BL) is an aggressive neoplasm characterized by consistent morphology and phenotype, typical clinical behavior and distinctive molecular profile.
Ambrosio, M., Bellan, C., Consiglio, J., Croce, C., De Falco, G., Etebari, M., Fuligni, F., Gibellini, D., Laginestra, M., Lazzi, S., Leoncini, L., Navari, M., Piccaluga, P., Pileri, S., Rogena, E., Rossi, M., Sapienza, M., Tripodo, C., Tumwine, L.   +18 more
core   +3 more sources

Immune-checkpoint expression in Epstein-Barr virus positive and negative plasmablastic lymphoma: a clinical and pathological study in 82 patients

Haematologica, 2016
Plasmablastic lymphoma is a rare and aggressive diffuse large B-cell lymphoma commonly associated with Epstein-Barr virus co-infection that most often occurs in the context of human immunodeficiency virus infection.
Camille Laurent, Bettina Fabiani, Catherine Do, Emmanuelle Tchernonog, Guillaume Cartron, Pauline Gravelle, Nadia Amara, Sandrine Malot, Maryknoll Mawanay Palisoc, Christiane Copie-Bergman, Alexandra Traverse Glehen, Marie-Christine Copin, Pierre Brousset, Stefania Pittaluga, Elaine S. Jaffe, Paul Coppo   +15 more
doaj   +1 more source

Epstein-Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression [PDF]

, 2015
Lytic replication of the human gamma herpes virus Epstein-Barr virus (EBV) is an essential prerequisite for the spread of the virus. Differential regulation of a limited number of cellular genes has been reported in B-cells during the viral lytic ...
Alison J. Sinclair, Anja Godfrey, Bailey, Bark-Jones, Beatty, Ben-Bassat, Bergbauer, Bhende, Bhende, Broderick, Carey, Chang, Chi, Farnham, Feederle, Feng, Flemington, Flower, Gentleman, Gordon Peters, Grabherr, Gupta, Gustems, Halder, Harshil Patel, Heather, Hollyoake, Hsu, Huang da, Huang da, Ijiel B. Naranjo Perez-Fernandez, Inman, Israel, Jiang, Jianmin Zuo, Kalla, Kalla, Kay Osborn, Kenney, Kenney, Klug, Krig, Kuppers, Li, Lieberman, Lieberman, Lieberman, Longnecker, Ma, Machanick, Martin Rowe, McClellan, Miller, Molyneux, Nicolae Balan, Pruitt, Rajaei Al-Mohammad, Ramasubramanyan, Ramasubramanyan, Richard G. Jenner, Rickinson, Rowe, Rowe, Scacheri, Shannon-Lowe, Sharada Ramasubramanyan, Takada, Thorvaldsdottir, Tsai, Tsang, Vetsika, Whyte, Yang, Young, Young, Yuan, Zuo, Zuo   +77 more
core   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Epstein-Barr virus (EBV) reactivation and therapeutic inhibitors

Journal of Clinical Pathology, 2019
Epstein-Barr virus (EBV) is a ubiquitous human virus which infects almost all humans during their lifetime and following the acute phase, persists for the remainder of the life of the individual. EBV infects B lymphocytes leading to their immortalisation,
J. Kerr
semanticscholar   +1 more source

Systematic review and meta-analysis of the sero-epidemiological association between Epstein Barr virus and multiple sclerosis [PDF]

, 2013
Peer reviewedPublisher ...
Almohmeed, Yahya H, Aucott, Lorna, Avenell, Alison, Vickers, Mark A   +3 more
core   +3 more sources

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Epstein‐Barr virus strain variation and cancer

Cancer Science, 2019
Epstein‐Barr virus (EBV) is a human tumor virus and is etiologically linked to various malignancies. Certain EBV‐associated diseases, such as Burkitt lymphomas and nasopharyngeal carcinomas, are endemic and exhibit biased geographic distribution ...
T. Kanda, Misako Yajima, K. Ikuta
semanticscholar   +1 more source

Epigenetic control of Epstein–Barr virus transcription – relevance to viral life cycle? [PDF]

, 2013
DNA methylation normally leads to silencing of gene expression but Epstein–Barr virus (EBV) provides an exception to the epigenetic paradigm. DNA methylation is absolutely required for the expression of many viral genes.
Sinclair, Alison J
core   +2 more sources