Results 101 to 110 of about 298,867 (391)

Atypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult‐Onset in a 46‐Year‐Old Male

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi, Michael Kutsche, Helena Lichtenfeld, Fanny Kortüm, Angela Abicht, Laura Herrmann, Theresia Herget   +6 more
wiley   +1 more source

Atypical manifestations of Epstein–Barr virus in children: a diagnostic challenge

Jornal de Pediatria, 2016
Objective: Clarify the frequency and the pathophysiological mechanisms of the rare manifestations of Epstein–Barr virus infection. Sources: Original research studies published in English between 1985 and 2015 were selected through a computer-assisted ...
Vasileios Bolis, Christos Karadedos, Ioannis Chiotis, Nikolaos Chaliasos, Sophia Tsabouri   +4 more
doaj   +1 more source

Epstein-Barr Virus Entry [PDF]

Journal of Virology, 2007
One of the many conundrums of herpesvirology is why a herpesvirus is so profligate in its use of four or more envelope glycoproteins for entry into a cell when other viruses can manage very well with only one or two. Profligacy does, however, have its advantages.
openaire   +2 more sources

Local Specific IgE Levels Can Predict and Monitor the Therapeutic Response to Subcutaneous Immunotherapy With House Dust Mite

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Identifying predictive and monitoring biomarkers for allergen immunotherapy response is crucial for enhancing clinical efficacy. This study aims to investigate the systemic and local levels of immunoglobulins and identify potential biomarkers in house dust mite (HDM) allergic rhinitis (AR) patients who are undergoing subcutaneous ...
Xu Xu, Jingyun Li, Xu Zhang, Yu Song, Lin Xi, Luo Zhang, Yuan Zhang   +6 more
wiley   +1 more source

Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth

Science Translational Medicine, 2019
EBNA1 inhibitors developed by fragment-based drug design block EBNA1 DNA binding and EBV-dependent tumor cell growth in vivo. No holds Barr-ed for cancer treatment Persistent latent infection with Epstein-Barr virus contributes to tumorigenesis in a ...
T. Messick, Garry R. Smith, S. Soldan, M. McDonnell, J. Deakyne, K. Malecka, Lois E Tolvinski, A. V. D. van den Heuvel, Baiwei Gu, J. Cassel, D.H. Tran, Benjamin R. Wassermann, Yan Zhang, Venkata Velvadapu, E. Zartler, P. Busson, A. Reitz, P. Lieberman   +17 more
semanticscholar   +1 more source

Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma : a preliminary study [PDF]

, 2008
The aim of this study was to analyze proliferative verrucous leukoplakia (PVL) and oral squamous cell carcinoma (OSCC) for the possible presence of Epstein-Barr virus (EBV).
Alberola, Trinidad M., Bagán Sebastián, José Vicente, Díaz Fernández, José María, Gavaldá Esteve, Carmen, Jiménez Soriano, Yolanda, Margaix Muñoz, María, Murillo Cortés, Judith, Poveda Roda, Rafael, Pérez Alonso, Manuel, Scully, Crispian, Torres Puente, Manuela   +10 more
core  

Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications [PDF]

, 2018
The Epstein-Barr virus (EBV) is a ubiquitous human \u3b3-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies.
Celeghin, Andrea, De Rossi, Anita, Giunco, Silvia, Petrara, Maria Raffaella, Zangrossi, Manuela   +4 more
core   +1 more source

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Although shifts in nasal microbiota have been well‐documented in inflammatory upper airway conditions, microbiota tumor‐associated alterations remain uncharacterized. This study is the first to compare sinonasal microbiota profiles of patients with malignant tumors (MT), benign tumors (BT), and controls, offering insights into tumor‐
Evan A. Patel, Phillip A. Engen, Glen D. Souza, Sarah Khalife, Donyea Moore, Lauren Kret, Pedro Escobedo, Stefan J. Green, Ankur Naqib, Peter Filip, Peter Papagiannopoulos, Bobby A. Tajudeen, Mahboobeh Mahdavinia, Pete S. Batra   +13 more
wiley   +1 more source

Systemic Epstein-Barr-virus-positive T cell lymphoproliferative childhood disease in a 22-year-old Caucasian man: A case report and review of the literature

Journal of Medical Case Reports, 2011
Introduction Systemic Epstein-Barr-virus-positive T cell lymphoproliferative disease of childhood is an extremely rare disorder, characterized by clonal proliferation of Epstein-Barr-virus-infected T cells with an activated cytotoxic phenotype.
Meloni Giovanna, Sista Maria, Righi Simona, Mannu Claudia, Capria Saveria, Bacci Francesco, Gazzola Anna, Sabattini Elena, Agostinelli Claudio, Tabanelli Valentina, Pileri Stefano A, Piccaluga Pier   +11 more
doaj   +1 more source

Novel Therapeutics for Epstein–Barr Virus

Molecules, 2019
Epstein–Barr virus (EBV) is a human γ-herpesvirus that infects up to 95% of the adult population. Primary EBV infection usually occurs during childhood and is generally asymptomatic, though the virus can cause infectious mononucleosis in 35–50% of the ...
G. Andrei, E. Trompet, R. Snoeck
semanticscholar   +1 more source