Results 91 to 100 of about 610,244 (306)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Tridimensional model structure and patterns of molecular evolution of Pepino mosaic virus TGBp3 protein

Virology Journal, 2011
Background Pepino mosaic virus (PepMV) is considered one of the most dangerous pathogens infecting tomatoes worldwide. The virus is highly diverse and four distinct genotypes, as well as inter-strain recombinants, have already been described.
Pospieszny Henryk, Czerwoniec Anna, Hasiów-Jaroszewska Beata, Elena Santiago F   +3 more
doaj   +1 more source

Phylogeography of Japanese encephalitis virus:genotype is associated with climate [PDF]

, 2013
The circulation of vector-borne zoonotic viruses is largely determined by the overlap in the geographical distributions of virus-competent vectors and reservoir hosts.
A Igarashi, A Oya, A Rambaut, A Rambaut, AB Sabin, AJ Auguste, AJ Drummond, AJ Drummond, AJ Schuh, AJ Schuh, AJ Schuh, Alan D. T. Barrett, Amy C. Morrison, Amy J. Schuh, Andrew J. Leigh Brown, B Shapiro, BJ Smith, D Martin, D Posada, DP Martin, DP Martin, EK Cruickshank, EL Buescher, EL Buescher, EL Buescher, EL Buescher, EL Buescher, FA Rey, FJ May, G Baele, GL Campbell, GM Jenkins, H Tsuchie, H Weissenbock, HS Hurlbut, HY Wang, J Fox, J Parker, JE Bryant, JH Nam, JL Wang, JM Smith, JN Hanna, L Lewis, L Rosen, L Rosen, L Rosen, M Gouy, M Padidam, MA Mohammed, MA Suchard, Melissa J. Ward, MH Li, N Nitatpattana, P Lemey, PD Uchil, PT Nga, PV Fulmali, R Takhampunya, RS Lanciotti, S Guindon, S Kumar, SE Sulkin, SE Sulkin, SL Kosakovsky Pond, SL Kosakovsky Pond, SL Pond, SL Pond, SP Ma, T Bakonyi, T Mitamura, T Solomon, TJ Chambers, WF Scherer, WF Scherer, WF Scherer, WM Hammon, WR Chen, WR Chen, WS Paul, XL Pan, Y Kobayashi, YX Li, YY Chen   +83 more
core   +3 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Co-Evolution of quasispecies: B-cell mutation rates maximize viral error catastrophes

, 2001
Co-evolution of two coupled quasispecies is studied, motivated by the competition between viral evolution and adapting immune response. In this co-adaptive model, besides the classical error catastrophe for high virus mutation rates, a second ...
A. Aigner, A. Sasaki, B. Jones, C. Berek, C. O. Wilke, C. Thompson, C. Wilke, Christel Kamp, D. McKean, E. Baake, E. van Nimwegen, G. Nossal, I. Roitt, M. Eigen, M. Eigen, M. F. Diaz, M. Meyer-Herrman, M. Nilsson, M. Nowak, M. Nowak, M. Weigert, N. S. Levy, P. Tarazona, R. S. Harris, S. Altmeyer, S. Bonhoeffer, S. Ganeshan, Stefan Bornholdt, T. Allen, T. Dörner   +29 more
core   +1 more source

Changes on the viral capsid surface during the evolution of porcine circovirus type 2 (PCV2) from 2009 till 2018 may lead to a better receptor binding [PDF]

, 2019
Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus-associated diseases (PCVAD). Three major PCV2 genotypes (PCV2a, PCV2b, and PCV2d) have been identified globally.
Nauwynck, Hans, Theuns, Sebastiaan, Wei, Ruifang, Xie, Jiexiong   +3 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Distribution and conservation of Banana Streak Virus (BSV) within banana Musa balbisiana genome: what impact on host and virus evolution ? [PDF]

, 2011
The nuclear genome of several plants isinvaded by numerous viral sequences. These integrations correspond to accidental events mainly resulting from illegitimate recombination of DNA viruses belonging to the family Caulimoviridae with plant DNA whereas ...
Chabannes, Matthieu, Duroy, Pierre-Olivier, Iskra Caruana, Marie-Line, Laboureau, Nathalie, Perrier, Xavier   +4 more
core   +2 more sources

Begomovirus quasispecies adapt to hosts by exploring different sequence space without changing their consensus sequences [PDF]

, 2014
Geminiviruses possess single-stranded circular DNA genomes that depend on cellular polymerases for replication in the host nucleus. In plant hosts, geminivirus populations behave as ensembles of mutant and recombinant genomes.
Domínguez-Huerta, Guillermo, Grande-Perez, Ana, Moriones, Enrique, Navas-Castillo, Jesus, Sánchez-Campos, Sonia, Tomás, Diego   +5 more
core