Results 101 to 110 of about 3,988,806 (312)

Evolution of the nucleoprotein gene of influenza A virus [PDF]

Journal of Virology, 1990
Nucleotide sequences of 24 nucleoprotein (NP) genes isolated from a wide range of hosts, geographic regions, and influenza A virus serotypes and 18 published NP gene sequences were analyzed to determine evolutionary relationships. The phylogeny of NP genes was determined by a maximum-parsimony analysis of nucleotide sequences.
O T, Gorman, W J, Bean, Y, Kawaoka, R G, Webster   +3 more
openaire   +2 more sources

Widespread interspecific phylogenetic tree incongruence between mosquito-borne and insect-specific flaviviruses at hotspots originally identified in Zika virus

, 2022
Intraspecies (homologous) phylogenetic incongruence, or 'tree conflict' between different loci within the same genome of mosquito-borne flaviviruses (MBFV), was first identified in dengue virus (DENV) and subsequently in Japanese encephalitis virus (JEV),
Gaunt, Bill, Gould, Ernest A., de Lamballerie, Xavier, Kuno, Goro,, de Lamballerie, Xavier,, Gould, Ernest A.,, Gould, Ernest A, Gaunt, Michael W.,, Pettersson, John, Gaunt, Michael W., Pettersson, John,, Gaunt, Michael W, Kuno, Goro, Pettersson, John H-O, Gaunt, Bill,   +14 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Genetic diversity of viruses of Chenuda virus species (Orbivirus, Reoviridae) circulating in Central Asia

Вопросы вирусологии, 2017
Chenuda virus (CNUV) (Orbivirus, Reoviridae) is the only known orbivirus associated with argas (Argasidae) ticks. Scientific study of this group is necessary for understanding of Orbivirus genus evolution patterns.
A. A. Eremyan, D. K. Lvov, A. M. Shchetinin, P. G. Deryabin, V. A. Aristova, A. K. Gitelman, A. G. Botikov, S. V. Alkhovsky   +7 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Geometry and virus evolution [PDF]

Science, 2015
Influenza An influenza pandemic is only a couple of mutations away. Or is it? Meyer and Wilke analyzed how the hemagglutinin protein of the H3 subtype of influenza has evolved, to learn how mutation allows this virus to escape host immune surveillance.
openaire   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Independent repeated mutations within the alphaviruses Ross River virus and Barmah Forest virus indicates convergent evolution and past positive selection in ancestral populations despite ongoing purifying selection [PDF]

Ross River virus (RRV) and Barmah Forest virus (BFV) are arthritogenic arthropod-borne viruses (arboviruses) that exhibit generalist host associations and share distributions in Australia and Papua New Guinea (PNG).
Paramitha, Devina, Haniotis, John, Caly, Leon, Cameron, Jane, Michie, Alice, Ramirez, Ana L, Pyke, Alyssa T, Doggett, Stephen L, Mee, Peter T, Wilson, Daniel J, Herrero, Lara J, Imrie, Allison, Lynch, Stacey E, et al., Mackenzie, John S, Madzokere, Eugene T   +15 more
core   +2 more sources

The evolution of parasitic and mutualistic plant-virus symbioses through transmission-virulence trade-offs. [PDF]

, 2017
Virus-plant interactions range from parasitism to mutualism. Viruses have been shown to increase fecundity of infected plants in comparison with uninfected plants under certain environmental conditions.
Sun, TA, Prendeville, HR, Hajimorad, MR, Hamelin, FM, Allen, LJS, Hilker, FM, Jeger, MJ, Hamelin, Frédéric, Marie, Hilker, Franck M., M. Reza Hajimorad, Hajimorad, M.Reza, Prendeville, Holly R, Linda J.S. Allen, Frank M. Hilker, Michael J. Jeger, Jeger, Michael. J., Frédéric M. Hamelin, Sun, Anthony T., Holly R. Prendeville, T. Anthony Sun, Allen, Linda J S   +20 more
core   +1 more source