Results 151 to 160 of about 4,863,377 (394)
Genetic Evolution and Molecular Selection of the HE Gene of Influenza C Virus [PDF]
, 2019 Influenza C virus (ICV) was first identified in humans and swine, but recently also in cattle, indicating a wider host range and potential threat to both the livestock industry and public health than was originally anticipated.
He, Wanting +10 more
core +1 more source
The evolution of virus–induced apoptosis
Proceedings of the Royal Society of London. Series B: Biological Sciences, 1997 Viruses from several different families are able to exploit their host's cell death programmes so as to maximize viral fitness. Consideration of the evolution of such strategies has lead to the suggestion that the virus should inhibit apoptosis, in order to prolong the life of the cell and thereby maximize the number of progeny virions.
Krakauer, DC, Payne, RJH
openaire +4 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Begomovirus quasispecies adapt to hosts by exploring different sequence space without changing their consensus sequences [PDF]
, 2014 Geminiviruses possess single-stranded circular DNA genomes that depend on cellular polymerases for replication in the host nucleus. In plant hosts, geminivirus populations behave as ensembles of mutant and recombinant genomes.
Domínguez-Huerta, Guillermo +5 more
core
Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]
, 2013 John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D +2 more
core +1 more source
Virus evolution and transmission in an ever more connected world
Proceedings of the Royal Society B: Biological Sciences, 2015 The frequency and global impact of infectious disease outbreaks, particularly those caused by emerging viruses, demonstrate the need for a better understanding of how spatial ecology and pathogen evolution jointly shape epidemic dynamics.
O. Pybus, A. Tatem, P. Lemey
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Inter- and intracontinental migrations and local differentiation have shaped the contemporary epidemiological landscape of canine parvovirus in South America [PDF]
, 2018 Canine parvovirus (CPV) is a fast-evolving single-stranded DNA virus that causes one of the most significant infectious diseasesof dogs. Although the virus dispersed over long distances in the past, current populations are considered to be ...
Aldaz, Jaime +11 more
core +1 more source
nextflu: real-time tracking of seasonal influenza virus evolution in humans
Bioinform., 2015 Summary: Seasonal influenza viruses evolve rapidly, allowing them to evade immunity in their human hosts and reinfect previously infected individuals.
R. Neher, T. Bedford
semanticscholar +1 more source
New Perspectives on Ebola Virus Evolution
PLOS ONE, 2016 (Uploaded by Plazi for the Bat Literature Project) Since the recent devastating outbreak of Ebola virus disease in western Africa, there has been significant effort to understand the evolution of the deadly virus that caused the outbreak. There has been a considerable investment in sequencing Ebola virus (EBOV) isolates, and the results paint an ...
Celeste J Brown +6 more
openaire +4 more sources