Results 141 to 150 of about 3,988,806 (312)

Deceleration and rebound of hemagglutinin divergence in influenza B/Victoria across COVID-19 NPI phases (2016–2024)

Frontiers in Microbiology
The COVID-19 pandemic reshaped global viral transmission and created a natural experiment to test how non-pharmaceutical interventions (NPIs) influence the evolution of co-circulating pathogens.
Yue Zhang, Bin Fu, Cuilian Yu, Sai Liu, Yongan Wang, Zhao Wang, Zhao Wang, Kezhou Wang   +7 more
doaj   +1 more source

Novel phylogenetic algorithm to monitor human tropism in Egyptian H5N1-HPAIV reveals evolution toward efficient human-to-human transmission [PDF]

, 2013
Years of endemic infections with highly pathogenic avian influenza (HPAI) A subtype H5N1 virus in poultry and high numbers of infections in humans provide ample opportunity in Egypt for H5N1-HPAIV to develop pandemic potential.
Ursula Dietrich (351656), Perovic, Vladimir R., Dietrich, Ursula, Veljković, Nevena V., Veljkovic, Nevena, Ursula Dietrich, Claude P. Muller (106167), Nevena Veljkovic, Henry L. Niman (407613), Dusan D Tosic, Nevena Veljkovic (338669), Veljko Veljkovic (315720), Sanja Glisic, Sanja Glisic (168160), Muller, Claude P., Dusan D. Tosic (407614), Vladimir R. Perovic (407612), Niman, Henry L., Veljkovic, Veljko, Tosic, Dusan D., Vladimir R Perovic, Claude P Muller, Veljko Veljkovic, Henry L Niman, Glisic, Sanja, Muller Claude P., Veljkovic Nevena, Perovic Vladimir R., Tosic Dusan D., Veljkovic Veljko, Dietrich Ursula, Glisic Sanja, Niman Henry L.   +32 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Host origin is a determinant of coevolution between gene segments of avian H9 influenza viruses

Journal of Virology
Several emerging influenza viruses, including H7N9 and H5N6 viruses, trace their origins to reassortment with H9N2 viruses that contributed internal gene segments.
Jennifer E. Jones, Seema S. Lakdawala
doaj   +1 more source

Biodiversity and evolution of Imjin virus and Thottapalayam virus in Crocidurinae shrews in Zhejiang Province, China

, 2014
The recent discovery of numerous hantaviruses in insectivores has provided a new view of hantavirus biodiversity and evolution. To determine the presence and genetic diversity of Imjin virus (MJNV) and Thottapalayam virus (TPMV) in insectivores in ...
Ying, Xu Hua, Wang, Wen, Lin, Xian Dan, Zhang, Yong Zhen, Zhou, Run Hong, Fan, Fei Neng, Sun, Xiao Yu, Holmes, Edward C.   +7 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The evolution of virus diseases: their emergence, epidemicity, and control

, 1993
The evolution of virus diseases, both their emergence and disappearance, involves complex interactions between the agent, the host, and the environment.
Wilesmith, John, Brookmeyer, Ronald, McGann, Kathleen A, Desrosiers, Ronald C, Nathanson, Neal   +4 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source