Results 131 to 140 of about 241,522 (268)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Contact-number-driven virus evolution: A multi-level modeling framework for the evolution of acute or persistent RNA virus infection. [PDF]

PLoS Comput Biol, 2023
Sunagawa J, Komorizono R, Park H, Hart WS, Thompson RN, Makino A, Tomonaga K, Iwami S, Yamaguchi R.   +8 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

PB1 mutations as key drivers of influenza A virus evolution. [PDF]

Front Microbiol
Fang C, Sun X, Feng Y, Song H, Wang S.
europepmc   +1 more source

Defects in plant immunity modulate the rates and patterns of RNA virus evolution. [PDF]

Virus Evol, 2022
Navarro R, Ambrós S, Butković A, Carrasco JL, González R, Martínez F, Wu B, Elena SF.   +7 more
europepmc   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Mexico as a hotspot for plant virus evolution: eco-evolutionary regimes shaping viral emergence. [PDF]

Front Plant Sci
Alcántar-Aguirre FC, Zamora-Macorra EJ, Gutiérrez UV, Carrillo-Tripp J, Diaz-Lara A, Aviña-Padilla K.   +5 more
europepmc   +1 more source

A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil. [PDF]

Microbiol Spectr, 2022
Giovanetti M, Pereira LA, Adelino TÉR, Fonseca V, Xavier J, de Araújo Fabri A, Slavov SN, da Silva Lemos P, de Almeida Marques W, Kashima S, Lourenço J, de Oliveira T, Campelo de Albuquerque CF, Freitas C, Peterka CRL, da Cunha RV, Mendonça AF, Lemes da Silva V, Alcantara LCJ.   +18 more
europepmc   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Genomic characterization of Sabiá virus in Brazil, 2019-2020: Implications for diagnostics, virus evolution, and receptor binding. [PDF]

PLoS Negl Trop Dis
Claro IM, Manuli ER, da Silva CAM, Coletti TM, Lemey P, Nastri AC, Casadio LVB, Duarte-Neto AN, Quick J, Romano CM, Whittaker C, Hill SC, Prete CA, Candido DS, Moreira FRR, Ramundo MS, Valença IN, de Jesus JG, Sales FCS, Cunha MS, Guerra JM, Mendes-Correa MC, Tozetto-Mendoza TR, Fumagalli MJ, Ho YL, Simmonds P, Ng WM, Bowden TA, de Souza WM, Pybus OG, Levin AS, Loman N, Sabino EC, Faria NR.   +33 more
europepmc   +1 more source