Results 41 to 50 of about 594,928 (357)

Oropouche virus: clinical, epidemiological, and molecular aspects of a neglected orthobunyavirus. [PDF]

open access: yes, 2017
Oropouche virus (OROV) is an important cause of arboviral illness in Latin American countries, more specifically in the Amazon region of Brazil, Venezuela and Peru, as well as in other countries such as Panama.
Acrani, Gustavo Olszanski   +6 more
core   +1 more source

Deep mutational scanning and CRISPR-engineered viruses: tools for evolutionary and functional genomics studies

open access: yesmSphere
Recent advancements in synthetic biology and sequencing technologies have revolutionized the ability to manipulate viral genomes with unparalleled precision.
Mercedes Paz, Gonzalo Moratorio
doaj   +1 more source

Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism

open access: yesmBio, 2019
APOBEC3B is a single-stranded DNA cytosine deaminase with beneficial innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by inflicting APOBEC signature C-to-T and C-to-G mutations in genomic DNA of multiple cancer types ...
Gabriel J. Starrett   +13 more
doaj   +1 more source

Dating the Emergence of Human Endemic Coronaviruses

open access: yesViruses, 2022
Four endemic coronaviruses infect humans and cause mild symptoms. Because previous analyses were based on a limited number of sequences and did not control for effects that affect molecular dating, we re-assessed the timing of endemic coronavirus ...
Diego Forni   +7 more
doaj   +1 more source

Comparative susceptibility of mosquito populations in North Queensland, Australia to oral infection with dengue virus. [PDF]

open access: yes, 2014
Dengue is the most prevalent arthropod-borne virus, with at least 40% of the world's population at risk of infection each year. In Australia, dengue is not endemic, but viremic travelers trigger outbreaks involving hundreds of cases.
Anderson   +47 more
core   +2 more sources

Evolution and Vaccination of Influenza Virus [PDF]

open access: yesJournal of Computational Biology, 2017
In this study, we present an application paradigm in which an unsupervised machine learning approach is applied to the high-dimensional influenza genetic sequences to investigate whether vaccine is a driving force to the evolution of influenza virus. We first used a visualization approach to visualize the evolutionary paths of vaccine-controlled and ...
Ham Ching Lam   +3 more
openaire   +3 more sources

Identification of drug resistance mutations in HIV from constraints on natural evolution [PDF]

open access: yes, 2015
Human immunodeficiency virus (HIV) evolves with extraordinary rapidity. However, its evolution is constrained by interactions between mutations in its fitness landscape.
Barton, John P.   +3 more
core   +2 more sources

Recombination and Positive Selection Differentially Shaped the Diversity of Betacoronavirus Subgenera

open access: yesViruses, 2020
The Betacoronavirus genus of mammal-infecting viruses includes three subgenera (Sarbecovirus, Embecovirus, and Merbecovirus), in which most known human coronaviruses, including SARS-CoV-2, cluster.
Diego Forni   +2 more
doaj   +1 more source

Viral Metagenomics Reveals Diverse Viruses in Tissue Samples of Diseased Pigs

open access: yesViruses, 2022
The swine industry plays an essential role in agricultural production in China. Diseases, especially viral diseases, affect the development of the pig industry and threaten human health.
Shixing Yang   +14 more
doaj   +1 more source

Contact transmission of influenza virus between ferrets imposes a looser bottleneck than respiratory droplet transmission allowing propagation of antiviral resistance [PDF]

open access: yes, 2016
Influenza viruses cause annual seasonal epidemics and occasional pandemics. It is important to elucidate the stringency of bottlenecks during transmission to shed light on mechanisms that underlie the evolution and propagation of antigenic drift, host ...
Ashcroft, J   +12 more
core   +1 more source

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