Results 71 to 80 of about 4,792 (218)

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Alphaherpesvirus: isolation, identification, partial characterisation, associated pathologic findings, and epidemiology in beluga whales (Delphinapterus leucas) in Alaska and Arctic Canada

Arctic Science, 2018
Live, dead stranded, and harvested belugas (Delphinapterus leucas) in Alaska and the western Canadian Arctic were screened for viruses utilizing a primary beluga cell line. Samples consisted of swabs from blowhole, anus, and genital tract.
Ole Nielsen, Kathleen A. Burek-Huntington, Lisa L. Loseto, Maria Morell, Carlos H. Romero   +4 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Epidemiological, virological, and pathogenic insights into Nairobi sheep disease virus infection in sheep and goats in China

Journal of Virology
Nairobi sheep disease virus (NSDV), a tick-borne pathogen in the Orthonairovirus genus of the Nairoviridae family, causes Nairobi sheep disease (NSD), which has mortality rates over 90% in sheep and goats.
Xin-Yan Yao, Meng-Hang Wang, Xue-Lian Zhang, Xu Zhang, De-Xin Liang, Shao-Han Li, Chun-Yang Lian, Zhi-Hang Lv, Chang-You Xia, Ming-fa Yang, Jian-Wei Shao, Xin Yin   +11 more
doaj   +1 more source

Human Metapneumovirus Detection in Patients with Severe Acute Respiratory Syndrome

Emerging Infectious Diseases, 2003
We used a combination approach of conventional virus isolation and molecular techniques to detect human metapneumovirus (HMPV) in patients with severe acute respiratory syndrome (SARS).
Rickjason C. W. Chan, John S. Tam, Ching-Wan Lam, Edward Chan, Alan Wu, Chi-Kong Li, Thomas A. Buckley, King-Cheung Ng, Gavin M. Joynt, Frankie W.T. Cheng, Ka-Fai To, Nelson Lee, David S.C. Hui, Jo L.K. Cheung, Ida Chu, Esther Liu, Sydney S.C. Chung, Joseph J.Y. Sung   +17 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Epidemiological Investigation of Goose Astrovirus in Hebei Province, China, 2019–2021

Microorganisms
The goose astrovirus (GAstV), a key pathogen causing visceral gout and high mortality in geese, has spread widely in China, with frequent outbreaks in recent years.
Ligong Chen, Huan Cui, Jiaqi Li, Yuxin Zhang, Heng Wang, Yejin Yang, Xuejing Wang, Cheng Zhang, Juxiang Liu   +8 more
doaj   +1 more source