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U-73122, a phospholipase C inhibitor, impairs lymphocytic choriomeningitis virus virion infectivity. [PDF]
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[Interferon in experimental infection with Junin virus].
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RNA composition of Junin virus
Journal of Virology, 1976Junin virus grown in BHK-21 cells was labeled with [3H]uridine and highly purified by differential and isopycnic centrifugation. The RNAs extracted with phenol and analyzed by polyacrylamide gel electrophoresis were shown to be composed of four large species (33, 28, and 18S) and three small ones (4, 5, and 5.5S).
M C, Añón +3 more
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Molecular characteristics of Junin virus
Journal of Virological Methods, 1997Results suggest that protein, glycerophospolipid, galactoside, and sialyl glycoside residues are present in Junin virus (JV), are accessible to enzymatic digestion, and play an important role in infection. Four major protein bands with molecular masses (Mr) 64 +/- 2, 56 +/- 2, 52 +/- 3 (mean +/- standard deviation, n = 4) and approximately 12-18 kDa ...
G, Bushar, J L, Sagripanti
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Lectin affinity of Junin virus glycoproteins
Annales de l'Institut Pasteur / Virologie, 1988We studied the binding of Junin virus (Arenaviridae) glycoproteins, G1 and G2, to two insolubilized lectins. The results showed that mannose, N-acetyl-glucosamine and galactose residues were exposed on G2, while only the latter predominated on G1. Heterogeneity of carbohydrate chains was found in G2, the only glycoprotein that was iodinated by the ...
S E, Mersich, V, Castilla, E B, Damonte
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2002
Argentine hemorrhagic fever (AHF) was recognized as a new clinical entity from the richest farming region of Argentina in the 1950s (Arribalzaga 1955). The etiologic agent of this disease, Junin virus (JUN), was isolated in 1958 (Parodi et al. 1958; Piroski et al. 1959).
D A, Enria, J G, Barrera Oro
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Argentine hemorrhagic fever (AHF) was recognized as a new clinical entity from the richest farming region of Argentina in the 1950s (Arribalzaga 1955). The etiologic agent of this disease, Junin virus (JUN), was isolated in 1958 (Parodi et al. 1958; Piroski et al. 1959).
D A, Enria, J G, Barrera Oro
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Actions of Complement on Junin Virus
Clinical Infectious Diseases, 1989Fresh sera from normal rhesus monkeys, guinea pigs, and rabbits inactivated 90%-99% of the infectivity of Vero cell-passaged, attenuated strains of Junin virus (JV) within 60 minutes. Selective depletion studies showed that inactivation occurred by the classical complement pathway. Complement had little effect on virulent JV strains.
R H, Kenyon, C J, Peters
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Characteristics of Junin Virus
Archiv f�r die gesamte Virusforschung, 19661. There is a linear relationship between the log dose of Junin virus inoculated in guinea pigs and the mean reciprocal time of death. 2. The decrease of infectivity is not significant when the virus is kept for 26 hours at 25° C or six hours at 37° C; but the inactivation is practically complete after 192 hours at 4° C, 72 hours at 25 ...
A S, Parodi +4 more
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Susceptible adult murine model for Junin virus
Journal of Medical Virology, 1988AbstractThe adult mouse model had been considered resistant to Junin virus (JV) infection. However, we found that C3H/HeJ murine strain proved highly susceptible up to 5 months of age to intracerebral inoculation with the prototype XJ JV strain, showing neurological signs and 80–90% mortality within 13 days. Neutralizing antibodies (Nt Ab) were absent,
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