Results 141 to 150 of about 2,624 (181)

Novel neutralizing monoclonal antibodies against Junin virus

Antiviral Research, 2018
Junin virus (JUNV) is the pathogen of Argentine haemorrhagic fever which results in high lethality, while there is limited therapeutics available. Here, a series of mouse monoclonal antibodies (mAbs) were isolated through immunization with DNA and screening against glycoprotein complex (GPC). Finally, five mAbs were found to effectively neutralize JUNV.
Xiaoyan Pan, Yan Wu, Wei Wang, Leike Zhang, Gengfu Xiao   +4 more
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Attenuated Junin virus infection in callithrix jacchus

Journal of Medical Virology, 1985
AbstractTwenty marmosets, male Callithrix jacchus, were used during this study. Fifteen of the marmosets were inoculated with 5,000 TCID50 of the attenuated XJCl3 strain of Junin virus by intramuscular route and five were left as uninoculated controls. Animals were observed for a 420‐day period.
M M, Avila, M J, Frigerio, E L, Weber, S, Rondinone, S R, Samoilovich, R P, Laguens, L B, de Guerrero, M C, Weissenbacher   +7 more
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Genetic Variation in Junin Virus

1993
Junin virus (JV) is a member of Arenaviridae able to cause a severe disease in humans known as Argentine hemorrhagic fever (AHF). The first isolation of this agent was performed in 1958 by Parodi et al. from a human case. Epidemics of AHF have occurred each year in the central area of the country, with incidence peaks coincident with harvest time of ...
Celia E. Coto, Elsa B. Damonte, Laura E. Alche, Luis Scolaro   +3 more
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Ribavirin effect on experimental Junin virus‐induced encephalitis

Journal of Medical Virology, 1988
AbstractJunin virus, the etiological agent of Argentine hemorrhagic fever, produces in man a disease mainly characterized by hemorrhagic alterations, commonly accompanied by neurological symptoms, and leading to 10% mortality. Intracerebral inoculation in 10‐day‐old rats or intraperitoneal inoculation in 2‐day‐old rats leads to high mortality due to ...
M C, Remesar, J L, Blejer, M C, Weissenbacher, M R, Nejamkis   +3 more
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Endothelial cell function alteration after Junin virus infection

Thrombosis and Haemostasis, 2003
SummaryHematologic involvement is the main feature of Argentine hemorrhagic fever (AHF), an endemo-epidemic disease caused by Junin virus (JV). Since endothelial dysfunction could play a role in AHF-altered hemostasis, we studied human umbilical vein endothelial cell (HUVEC) infection with a virulent (JVv) and a non-virulent (JVa) JV strain. Cells were
Ricardo Martin, Gomez, Roberto Gabriel, Pozner, Maria Angela, Lazzari, Lina Paola, D'Atri, Soledad, Negrotto, Ana Marisa, Chudzinski-Tavassi, María Isabel, Berría, Mirta, Schattner   +7 more
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Formalin inactivated junin virus: Immunogenicity and protection assays

Journal of Medical Virology, 1989
AbstractThe aim of this study was to determine if Junin virus inactivated with formalin (FA) was immunogenic and able to elicit a protective response in the guinea pig. The XJ‐Clone 3 strain of Junin virus grown in Vero cells was exposed to FA at 0°C.
C, Videla, G, Carballal, P, Remorini, J, La Torre   +3 more
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Inapparent Infections with Junin Virus among Laboratory Workers

Journal of Infectious Diseases, 1978
Mercedes C. Weissenbacher, Maria E. Grela, Marta S. Sabattini, J. I. Maiztegui, Celia E. Coto, M. J. Frigerio, P. M. Cossio, Adriana S. Rabinovich, and J. G. Barrera Oro From the Cdtedra de Microbiologia y Parasitologia, Facultad de Medicina, and Cdtedra de Microbiologia, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos ...
M C, Weissenbacher, M E, Grela, M S, Sabattini, J I, Maiztegui, C E, Coto, M J, Frigerio, P M, Cossio, A S, Rabinovich, J G, Barrera Oro   +8 more
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Junin Virus Infection of Callithrix Jacchus: Pathologic Features

The American Journal of Tropical Medicine and Hygiene, 1983
Infection of Callithrix jacchus, a New World primate, with the prototype strain of Junin virus produced a severe disease. The animals developed multifocal hemorrhages and characteristic microscopic lesions such as meningoencephalitis, interstitial pneumonia, lymphocytic depletion of lymphatic tissue, hepatocytic necrosis, and a variable decrease in ...
P H, González, R P, Laguens, M J, Frigerio, M A, Calello, M C, Weissenbacher   +4 more
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In vitro selection of Junin virus antigenic variants

Archives of Virology, 1993
The establishment of an experimental persistent infection with Junin virus, the aetiological agent of argentine hemorrhagic fever, involves the emergence of antigenic variants in brain and blood of the cricetid Calomys musculinus. We demonstrate that antigenic variants can also be isolated in vitro under the selective pressure of polyclonal antibodies ...
L E, Alché, C E, Coto
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Calomys callidus as a potential junin virus reservoir

Journal of Medical Virology, 1989
AbstractThe present study investigated whether C. callidus, a species belonging to the Calomys genus, is capable of developing experimentally a persistent Junin virus (JV) infection. Newborn and adult cricetids were inoculated with the attenuated XJ‐Clone 3 strain of JV by intracerebral or mucosal route. The present results indicate that the species is
C, Videla, A, Kajon, G, Carballal, M, Weissenbacher   +3 more
openaire   +2 more sources