Results 191 to 200 of about 1,043,974 (224)
Some of the next articles are maybe not open access.
Genetic Variation in Junin Virus
1993Junin virus (JV) is a member of Arenaviridae able to cause a severe disease in humans known as Argentine hemorrhagic fever (AHF). The first isolation of this agent was performed in 1958 by Parodi et al. from a human case. Epidemics of AHF have occurred each year in the central area of the country, with incidence peaks coincident with harvest time of ...
Celia E. Coto +3 more
openaire +1 more source
In vitro selection of Junin virus antigenic variants
Archives of Virology, 1993The establishment of an experimental persistent infection with Junin virus, the aetiological agent of argentine hemorrhagic fever, involves the emergence of antigenic variants in brain and blood of the cricetid Calomys musculinus. We demonstrate that antigenic variants can also be isolated in vitro under the selective pressure of polyclonal antibodies ...
L E, Alché, C E, Coto
openaire +2 more sources
Attenuated Junin virus infection in callithrix jacchus
Journal of Medical Virology, 1985AbstractTwenty marmosets, male Callithrix jacchus, were used during this study. Fifteen of the marmosets were inoculated with 5,000 TCID50 of the attenuated XJCl3 strain of Junin virus by intramuscular route and five were left as uninoculated controls. Animals were observed for a 420‐day period.
M M, Avila +7 more
openaire +2 more sources
An antibody for fighting Junin virus
C&EN Global Enterprise, 2016Argentine hemorrhagic fever was discovered in the 1950s, and it hasn’t spread beyond Argentina’s borders since. But the illness’s mortality rate—which can be as high as 30%—has public health officials worried. The fever is caused by Junin virus and transmitted by rodents through their saliva and droppings, so it could spread outside its current range ...
openaire +1 more source
Involvement of vacuolar proton ATPase in Junin virus multiplication
Archives of Virology, 2001The role of vacuolar-proton ATPase (V-H+ ATPAse) on Junin virus (JV) replication was evaluated by analyzing the effect of specific inhibitors of the enzyme activity on different steps of virus multiplication cycle. The presence of the macrolide antibiotics bafilomycin A1 and concanamycin A during the first two hours of infection caused a significant ...
V, Castilla, L M, Palermo, C E, Coto
openaire +2 more sources
Calomys callidus as a potential junin virus reservoir
Journal of Medical Virology, 1989AbstractThe present study investigated whether C. callidus, a species belonging to the Calomys genus, is capable of developing experimentally a persistent Junin virus (JV) infection. Newborn and adult cricetids were inoculated with the attenuated XJ‐Clone 3 strain of JV by intracerebral or mucosal route. The present results indicate that the species is
C, Videla +3 more
openaire +2 more sources
Junin Virus Infection of Callithrix Jacchus: Pathologic Features
The American Journal of Tropical Medicine and Hygiene, 1983Infection of Callithrix jacchus, a New World primate, with the prototype strain of Junin virus produced a severe disease. The animals developed multifocal hemorrhages and characteristic microscopic lesions such as meningoencephalitis, interstitial pneumonia, lymphocytic depletion of lymphatic tissue, hepatocytic necrosis, and a variable decrease in ...
P H, González +4 more
openaire +2 more sources
Novel neutralizing monoclonal antibodies against Junin virus
Antiviral Research, 2018Junin virus (JUNV) is the pathogen of Argentine haemorrhagic fever which results in high lethality, while there is limited therapeutics available. Here, a series of mouse monoclonal antibodies (mAbs) were isolated through immunization with DNA and screening against glycoprotein complex (GPC). Finally, five mAbs were found to effectively neutralize JUNV.
Xiaoyan Pan +4 more
openaire +2 more sources
Intermediate filament integrity is required for Junin virus replication
Virus Research, 2003The role of the cytoskeletal framework in Junin virus (JUNV) replication has already been demonstrated with compounds interfering with the microfilament (MF) and microtubule (MT) networks. In this work, we evaluated the role of intermediate filaments (IF) during JUNV infection. We tested the effect of acrylamide, a compound that selectively disrupts IF,
Sandra M, Cordo, Nélida A, Candurra
openaire +2 more sources
Depression of ?Jones Mote? type hypersensitivity by Junin virus
Archiv f�r die gesamte Virusforschung, 1970The effect of Junin virus infection on the active and passive delayed hyper-sensitivity of Jones Mote type in guinea pigs was studied. It was shown that in both types of hypersensitivity there is a suppression of the cutaneous reaction.
N R, Nota +3 more
openaire +2 more sources