Results 171 to 180 of about 76,412 (247)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Characterizing Combined Central and Peripheral Demyelination—Insights From a Multimodal Comparison With Chronic Inflammatory Demyelinating Polyneuropathy and Multiple Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Combined central and peripheral demyelination (CCPD) is a rare dysimmune disorder sharing features with multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Direct comparisons of central and peripheral diagnostic findings across these entities remain limited. We, therefore, performed a
N. Dubuisson, A. Kassab, P. Y. K. Van den Bergh, A. F. J. E. Vrancken, W. L. van der Pol, L. H. van den Berg, H. S. Goedee   +6 more
wiley   +1 more source

Optimal Control Analysis of Vertically Transmitted Infectious Diseases With Saturated Incidence and Nonlinear Treatment

Optimal Control Applications and Methods, EarlyView.
Schematic representation of the proposed disease transmission model incorporating vertical transmission, saturated incidence, and nonlinear treatment. The study combines theoretical analysis, bifurcation and stability investigations, and optimal control techniques to evaluate prevention and treatment interventions.
Oludolapo A. Olanrewaju, Sulaimon F. Abimbade   +1 more
wiley   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Interferon-γ-inducible protein 16 (IFI16) is required for the maintenance of Epstein-Barr virus latency. [PDF]

Virol J, 2017
Pisano G, Roy A, Ahmed Ansari M, Kumar B, Chikoti L, Chandran B.   +5 more
europepmc   +1 more source

Endoscopic Treatment for Esophagogastric Variceal Bleeding in Patients With Acute‐on‐Chronic Liver Failure: An Observational Study

Portal Hypertension &Cirrhosis, EarlyView.
In patients with acute‐on‐chronic liver failure (ACLF), esophagogastric variceal bleeding (EGVB) represents a critical complication associated with high short‐term mortality. This study evaluated the efficacy of endoscopic treatment in this specific population and identified prognostic factors associated with 6‐week rebleeding and mortality.
Yanan Sun, Peng Li, Shibin Zhang, Yuening Zhang, Chunlei Fan, Ajuan Zeng, Yanna Liu, Huiguo Ding   +7 more
wiley   +1 more source

Controlling banana bunchy top disease in Benin: Crop protection strategies with socio‐economic perspectives

PLANTS, PEOPLE, PLANET, EarlyView.
Banana and plantain are vital for food security and income in West Africa, yet banana bunchy top virus (BBTV) threatens production. This study combined remote sensing, field surveys, modelling and socio‐economic analysis to assess BBTV spread and control strategies in Benin.
Renata Retkute, Martine Zandjanakou‐Tachin, Bonaventure Aman Omondi, Ulrich Roland Agoi, Yaovi Marc Vodounou, Hermine Akofodji, Evrard Akpla, Laurence Dossou, Emiline Médénou, Alban Etchiha, Alphonse Attadéou, P. Lava Kumar, John E. Thomas, Christopher A. Gilligan   +13 more
wiley   +1 more source

Rootstock impacts on citrus flush dynamics, vegetative growth, and Diaphorina citri infestation and dispersion: Implications for huanglongbing management

Pest Management Science, EarlyView.
Dwarfing citrus rootstocks restrict flush shoot growth on the scion, thereby reducing Asian citrus psyllid infestation, dispersal, and huanglongbing (HLB) progression. These findings support the use of dwarfing rootstocks as an effective cultural strategy in integrated HLB management for citrus orchards.
Deived Uilian de Carvalho, Eduardo Augusto Girardi, Wellington Ivo Eduardo, Haroldo Xavier Linhares Volpe, Fernando Alves de Azevedo, Marcelo Pedreira de Miranda, Renato Beozzo Bassanezi   +6 more
wiley   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Partial or complete blocking of gD binding to HVEM affects primary and latent HSV-1 infection as well as eye disease in HSV-1 infected mice. [PDF]

PLoS Pathog
Arya D, Jaggi U, Oh JJ, Wang S, Ghiasi H.   +4 more
europepmc   +1 more source