Results 21 to 30 of about 3,841 (208)

Mannose Receptor 1 Restricts HIV Particle Release from Infected Macrophages

Cell Reports, 2018
Human mannose receptor 1 (hMRC1) is expressed on the surface of most tissue macrophages, dendritic cells, and select lymphatic or liver endothelial cells. HMRC1 contributes to the binding of HIV-1 to monocyte-derived macrophages (MDMs) and is involved in
Sayaka Sukegawa, Eri Miyagi, Fadila Bouamr, Helena Farkašová, Klaus Strebel   +4 more
doaj   +1 more source

Trypsin promotes porcine deltacoronavirus mediating cell-to-cell fusion in a cell type-dependent manner

Emerging Microbes and Infections, 2020
Porcine deltacoronavirus (PDCoV) is a newly emerging threat to the global porcine industry. PDCoV has been successfully isolated using various medium additives including trypsin, and although we know it is important for viral replication, the mechanism ...
Yue-Lin Yang, Fandan Meng, Pan Qin, Georg Herrler, Yao-Wei Huang, Yan-Dong Tang   +5 more
doaj   +1 more source

Functional characterization of the putative hepatitis B virus core protein late domain using retrovirus chimeras. [PDF]

PLoS ONE, 2013
The hepatitis B virus (HBV) Core protein encodes a late (L)-domain like motif (129PPAYRPPNAP(138)) that has been purported to serve as a docking site for recruitment of host factors such as Nedd4 that can mediate viral particle release from infected ...
Mayra L Garcia, Tracy D Reynolds, Walther Mothes, Michael D Robek   +3 more
doaj   +1 more source

Role of Heparanase and Syndecan-1 in HSV-1 Release from Infected Cells

Viruses, 2022
Herpes Simplex Virus 1 (HSV-1) is a neurotropic human virus that belongs to the Alphaherpesvirinae subfamily of Herpesviridae. Establishment of its productive infection and progression of disease pathologies depend largely on successful release of ...
Pankaj Sharma, Divya Kapoor, Deepak Shukla   +2 more
doaj   +1 more source

Eurasian-origin gene segments contribute to the transmissibility, aerosol release, and morphology of the 2009 pandemic H1N1 influenza virus. [PDF]

PLoS Pathogens, 2011
The epidemiological success of pandemic and epidemic influenza A viruses relies on the ability to transmit efficiently from person-to-person via respiratory droplets.
Seema S Lakdawala, Elaine W Lamirande, Amorsolo L Suguitan, Weijia Wang, Celia P Santos, Leatrice Vogel, Yumiko Matsuoka, William G Lindsley, Hong Jin, Kanta Subbarao   +9 more
doaj   +1 more source

High-Mannose But Not Complex-Type Glycosylation of Tetherin Is Required for Restriction of HIV-1 Release

Viruses, 2018
Tetherin is an interferon-inducible antiviral protein that inhibits the release of a broad spectrum of enveloped viruses by retaining virions at the surface of infected cells.
Abdul A. Waheed, Ariana Gitzen, Maya Swiderski, Eric O. Freed   +3 more
doaj   +1 more source

Generation and validation of a highly sensitive bioluminescent HIV-1 reporter vector that simplifies measurement of virus release

Retrovirology, 2020
Background The continued persistence of HIV-1 as a public health concern due to the lack of a cure calls for the development of new tools for studying replication of the virus.
James Kirui, Eric O. Freed
doaj   +1 more source

H9N2 virus-derived M1 protein promotes H5N6 virus release in mammalian cells: Mechanism of avian influenza virus inter-species infection in humans.

PLoS Pathogens, 2021
H5N6 highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4 not only exhibits unprecedented intercontinental spread in poultry, but can also cause serious infection in humans, posing a public health threat.
Fangtao Li, Jiyu Liu, Jizhe Yang, Haoran Sun, Zhimin Jiang, Chenxi Wang, Xin Zhang, Yinghui Yu, Chuankuo Zhao, Juan Pu, Yipeng Sun, Kin-Chow Chang, Jinhua Liu, Honglei Sun   +13 more
doaj   +1 more source

Anti-DHAV-1 reproduction and immuno-regulatory effects of a flavonoid prescription on duck virus hepatitis

Pharmaceutical Biology, 2017
Context: The flavonoid prescription baicalin-linarin-icariin-notoginsenoside R1 (BLIN) has a curative effect on duck virus hepatitis (DVH) caused by duck hepatitis A virus type 1 (DHAV-1). However, the mechanism of this curative effect is not understood.
Yun Chen, Ling Zeng, Jingjing Yang, Yixuan Wang, Fangke Yao, Yi Wu, Deyun Wang, Yuanliang Hu, Jiaguo Liu   +8 more
doaj   +1 more source

The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu

Retrovirology, 2009
Background The Human Immunodeficiency virus type 1 (HIV-1) Vpu protein enhances virus release from infected cells and induces proteasomal degradation of CD4.
Strebel Klaus, Kao Sandra, Miyagi Eri, Andrew Amy J   +3 more
doaj   +1 more source