Results 91 to 100 of about 732,521 (313)

Influence of retinoblastoma-related gene silencing on the initiation of DNA replication by African cassava mosaic virus Rep in cells of mature leaves in Nicotiana benthamiana plants [PDF]

, 2011
Background Geminiviruses mainly infect terminally differentiated tissues and cells in plants. They need to reprogramme host cellular machinery for DNA replication.
Bruce, Gareth, Gu, Mei, Shi, Nongnong, Liu, Yule, Hong, Yiguo   +4 more
core   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Rainbow Kaposi's Sarcoma-Associated Herpesvirus Revealed Heterogenic Replication with Dynamic Gene Expression. [PDF]

, 2020
Molecular mechanisms of Kaposi's sarcoma-associated herpesvirus (KSHV) reactivation have been studied primarily by measuring the total or average activity of an infected cell population, which often consists of a mixture of both nonresponding and ...
Campbell, Mel, Chuang, Frank, Guevara-Plunkett, Sara, Izumiya, Chie, Izumiya, Yoshihiro, Kumar, Ashish, Luxardi, Guillaume, Lyu, Yuanzhi, Nakajima, Ken-Ichi, Soulika, Athena, Wang, Kang-Hsin   +10 more
core  

Culex quinquefasciatus mosquitoes do not support replication of Zika virus [PDF]

, 2017
The rapid spread of Zika virus (ZIKV) in the Americas raised many questions about the role of Culex quinquefasciatus mosquitoes in transmission, in addition to the key role played by the vector Aedes aegypti.
Failloux, Anna-Bella, Guimarães Rocha Aguiarr, Eric Roberto, Kohl, Alain, Lourenço-de-Oliveira, Ricardo, Marques, João T., Nten, Célestine Atyame, Sreenu, Vattipally B., Varjak, Margus   +7 more
core   +3 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]

, 2014
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis, Gonzalez, Silvia Adriana   +1 more
core   +4 more sources

Hepatitis C virus replication cycle

Journal of Hepatology, 2010
Ecole Normale Superieure de Lyon,Lyon F-69007, FranceHepatitis C virus (HCV) is a positive strand RNA virus forming thegenus Hepacivirus in the Flaviviridae family. Replication of HCVstarts with the virus binding to hepatocytes, which are the pri-mary, if not exclusive host cells. HCV entry is a multi-step andslow process (Panel 1).
Bartenschlager, Ralf, Cosset, Francois-Loic, Lohmann, Volker   +2 more
openaire   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Apoptosis in the lungs of pigs infected with porcine reproductive and respiratory syndrome virus and associations with the production of apoptogenic cytokines [PDF]

, 2003
International audienceApoptosis was studied in the lungs of pigs during an infection with a European strain of porcine reproductive and respiratory syndrome virus (PRRSV) and it was examined if cytokines were involved in the induction of apoptosis ...
Labarque, Geoffrey, Nauwynck, Hans, Pensaert, Maurice, Van Gucht, Steven, Van Reeth, Kristien   +4 more
core   +3 more sources

Shedding light on virus replication [PDF]

Proceedings of the National Academy of Sciences, 2008
I am pleased to comment on “Visualizing the dynamics of viral replication in living cells via TAT peptide delivery of nuclease-resistant molecular beacons,” by Hsiao-Yun Yeh et al. (1), appearing in this issue of PNAS. I regard it as a very important contribution to animal (including human) virology because it allows observation of early events in ...
openaire   +2 more sources