Results 81 to 90 of about 732,521 (313)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Promotion of Hendra virus replication by microRNA 146a

, 2013
Hendra virus is a highly pathogenic zoonotic paramyxovirus in the genus Henipavirus. Thirty-nine outbreaks of Hendra virus have been reported since its initial identification in Queensland, Australia, resulting in seven human infections and four ...
A. G. Bean, A. J. Foord, Algarte, Bartel, Boldin, Brown, C. Deffrasnes, C. R. Stewart, Cahir McFarland, Cameron, Chen, Ciancanelli, D. Middleton, DiDonato, Feldman, Fiedler, G. A. Marsh, Gantier, Gantier, Gilad, Griffin, H. G. Heine, Halpin, Hou, J. A. Pallister, J. Haining, J. Stambas, J. W. Lowenthal, Jacque, Jopling, K. A. Jenkins, L. Izzard, L.-F. Wang, Lanford, Laurie, Lee, Lee, Levy, Li, Liu, M. L. Tizard, M. P. Gantier, Marianneau, Marsh, Marusawa, Meister, Mitchell, Murray, O'Connell, Pahl, Pallister, Pegtel, Pierce, Playford, R. Robinson, Reed, Santhakumar, Sarasin-Filipowicz, Schwarz, Shaw, Shembade, Shi, T. J. Gough, Taganov, Tomari, Virtue, Wang, Yoneyama, Zhao   +68 more
core   +1 more source

mRNA Display Design of Fibronectin-based Intrabodies That Detect and Inhibit Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein [PDF]

, 2009
The nucleocapsid (N) protein of severe acute respiratory syndrome (SARS) coronavirus plays important roles in both viral replication and modulation of host cell processes.
Amstutz, C. Anders Olson, Cardinale, Cardinale, Carlson, Carter, Chakrabarti, Chang, Chen, Elaine Wong, Enjuanes, Hongyu Deng, Hosse, Hsiang-I. Liao, Ja, Kawe, Koide, Lipovsek, Liu, Luo, Maynard, Milligan, Nizak, Olson, Olson, Rajpal, Ralph S. Baric, Ren Sun, Richard W. Roberts, Roberts, Roberts, Rota, Saikatendu, Satija, Seungmin Hwang, Stocks, Surjit, Vascotto, Visintin, Yount, Yu   +40 more
core   +4 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer

mBio
The integration of HPV DNA into human chromosomes plays a pivotal role in the onset of papillomavirus-related cancers. HPV DNA integration often occurs by linearizing the viral DNA in the E1/E2 region, resulting in the loss of a critical viral early ...
Lulu Yu, Vladimir Majerciak, Alexei Lobanov, Sameer Mirza, Vimla Band, Haibin Liu, Maggie Cam, Stephen H. Hughes, Douglas R. Lowy, Zhi-Ming Zheng   +9 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Chemokine expression and viral infection of the central nervous system: regulation of host defense and neuropathology. [PDF]

, 2001
An effective host response against viral infection of the central nervous system (CNS) is the principal factor dictating the outcome of infection. It is the responsibility of the immune response to contain and control viral replication. Paradoxically, it
Lane, TE, Liu, MT
core  

Stability of a stochastically perturbed model of intracellular single-stranded RNA virus replication

, 2019
Replication of single-stranded RNA virus can be complicated, compared to that of double-stranded virus, as it require production of intermediate antigenomic strands that then serve as template for the genomic-sense strands.
Elena, Santiago F., Korobeinikov, Andrei, Shaikhet, Leonid   +2 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication

Cell Reports, 2019
Summary: HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP6) for viral production and primary cell replication.
Donna L. Mallery, K.M. Rifat Faysal, Alex Kleinpeter, Miranda S.C. Wilson, Marina Vaysburd, Adam J. Fletcher, Mariia Novikova, Till Böcking, Eric O. Freed, Adolfo Saiardi, Leo C. James   +10 more
doaj   +1 more source