Results 101 to 110 of about 1,825,715 (311)

Helicoverpa armigera nucleopolyhedrovirus occlusion-derived virus-associated protein, HA100, affects oral infectivity in vivo but not virus replication in vitro [PDF]

, 2011
ORF100 (ha100) of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) has been reported as one of the unique genes of group II alphabaculoviruses encoding a protein located in the occlusion-derived virus (ODV) envelope and nucleocapsid.
Xushi Xu, Luo, S., Just M. Vlak, Fei Deng, Xu, X., Wang, H., Vlak, J.M., Deng, F., Zhang, Y., Yanfang Zhang, Marcel Westenberg, Sijiani Luo, Westenberg, M., Hu, Z., Hualin Wang, Zhihong Hu   +15 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

HIV-1 transcription start sites usage and its impact on unspliced RNA functions in people living with HIV

mBio
HIV-1 unspliced RNA serves two distinct functions during viral replication: it is packaged into particles as the viral genome, and it is translated to generate Gag/Gag-Pol polyproteins required for virus assembly. Recent studies have demonstrated that in
Saiful Islam, Frank Maldarelli, Olga A. Nikolaitchik, Zetao Cheng, Robert Gorelick, Maria A. Nikolaitchik, Vinay K. Pathak, Wei-Shau Hu   +7 more
doaj   +1 more source

Virus Replication

, 2011
This chapter describes virus replication. Before the development of in vitro cell culture techniques, all viruses had to be propagated in their natural host. For bacterial viruses, this was a relatively simple process that permitted an earlier development of laboratory research methods than was possible with plant or animal viruses. For animal viruses,
openaire   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

The Host Protein Reticulon 3.1A Is Utilized by Flaviviruses to Facilitate Membrane Remodelling

Cell Reports, 2017
Summary: Flaviviruses are enveloped, positive-sensed single-stranded RNA viruses that remodel host membranes, incorporating both viral and host factors facilitating viral replication.
Turgut E. Aktepe, Susann Liebscher, Julia E. Prier, Cameron P. Simmons, Jason M. Mackenzie   +4 more
doaj   +1 more source

Rapid generation of replication-deficient monovalent and multivalent vaccines for bluetongue virus: protection against virulent virus challenge in cattle and sheep.

, 2013
Since 1998, 9 of the 26 serotypes of bluetongue virus (BTV) have spread throughout Europe, and serotype 8 has suddenly emerged in northern Europe, causing considerable economic losses, direct (mortality and morbidity) but also indirect, due to ...
Hoffmann, B., C.C.P. Celma, Wernike, Kerstin, Eschbaumer, M., Wernike, K., De Clercq, K., van Rijn, Piet A, Haegeman, Andy, Beer, M., B. Hoffmann, A. Haegeman, P.A. van Rijn, van Rijn, P.A., Clercq, K., De, Celma, C.C.P., Eschbaumer, Michael, P. Roy, Boyce, Mark, Roy, Polly, M. Boyce, Roy, P., Hoffmann, Bernd, De Clercq, Kris, Rijn, P.A., van, M. Beer, Boyce, M., M. Eschbaumer, Celma, Cristina CP, K. De Clercq, Beer, Martin, K. Wernike, Haegeman, A.   +31 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Studies on influenza A virus PB1-F2 protein [PDF]

, 2011
The influenza A virus genome codes for up to 12 proteins. Segment 2 encodes three proteins, the polymerase subunit PB1, a small protein PB1-F2 and an N-terminally truncated version of PB1 called N40. Different functions have been reported for PB1-F2 such
Vater, Sandra
core   +2 more sources