Results 121 to 130 of about 675,632 (363)

Oxygen tension and virus replication.

Acta virologica, 1998
An evidence is accumulating that the oxygen tension exerts significant effect on the virus replication in vitro. When the in vitro oxygen tension is maintained at an in vivo physiological level, as a rule higher yields of human viruses are seen that at conventional culturing with access of an unphysiologically high oxygen concentration in ambient air ...
Ebbesen, P., Zachar, V.
openaire   +2 more sources

Hepatitis C Virus Replication

Cold Spring Harbor Perspectives in Medicine, 2019
Replication and amplification of the viral genome is a key process for all viruses. For hepatitis C virus (HCV), a positive-strand RNA virus, amplification of the viral genome requires the synthesis of a negative-sense RNA template, which is in turn used for the production of new genomic RNA. This process is governed by numerous proteins, both host and
Ralf Bartenschlager, Ralf Bartenschlager, Christopher J. Neufeldt, Keisuke Tabata   +3 more
openaire   +3 more sources

HIV-1 virus cycle replication: a review of RNA polymerase II transcription, alternative splicing and protein synthesis [PDF]

arXiv, 2019
HIV virus replication is a time-related process that includes several stages. Focusing on the core steps, RNA polymerase II transcripts in an early stage pre-mRNA containing regulator proteins (i.e nef,tat,rev,vif,vpr,vpu), which are completely spliced by the spliceosome complex (0.9kb and 1.8kb) and exported to the ribosome for protein synthesis ...
arxiv  

Promotion of Hendra virus replication by microRNA 146a

, 2013
Hendra virus is a highly pathogenic zoonotic paramyxovirus in the genus Henipavirus. Thirty-nine outbreaks of Hendra virus have been reported since its initial identification in Queensland, Australia, resulting in seven human infections and four ...
A. G. Bean, A. J. Foord, Algarte, Bartel, Boldin, Brown, C. Deffrasnes, C. R. Stewart, Cahir McFarland, Cameron, Chen, Ciancanelli, D. Middleton, DiDonato, Feldman, Fiedler, G. A. Marsh, Gantier, Gantier, Gilad, Griffin, H. G. Heine, Halpin, Hou, J. A. Pallister, J. Haining, J. Stambas, J. W. Lowenthal, Jacque, Jopling, K. A. Jenkins, L. Izzard, L.-F. Wang, Lanford, Laurie, Lee, Lee, Levy, Li, Liu, M. L. Tizard, M. P. Gantier, Marianneau, Marsh, Marusawa, Meister, Mitchell, Murray, O'Connell, Pahl, Pallister, Pegtel, Pierce, Playford, R. Robinson, Reed, Santhakumar, Sarasin-Filipowicz, Schwarz, Shaw, Shembade, Shi, T. J. Gough, Taganov, Tomari, Virtue, Wang, Yoneyama, Zhao   +68 more
core   +1 more source

Human papillomavirus E2 regulates SRSF3 (SRp20) to promote capsid protein expression in infected differentiated keratinocytes [PDF]

, 2016
The human papillomavirus (HPV) life cycle is tightly linked to differentiation of the infected epithelial cell suggesting a sophisticated interplay between host cell metabolism and virus replication.
Beemon, K. L., Bodily, J. M., Graham, S. V., Hernandez-Lopez, H., Klymenko, Tetyana, MacDonald, A. I.   +5 more
core   +2 more sources

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response. [PDF]

, 2014
Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, interferon (IFN)-dependent upregulation of IFN-stimulated genes (ISGs), and the activity
Asensio, VJ, Bengoechea, JA, Fernández, Y, Killip, MJ, Oliveros, JC, Ortín, J, Pérez-Cidoncha, M, Randall, RE   +7 more
core   +2 more sources

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly

Nature Communications
The HIV-1 capsid is composed of capsid (CA) protein hexamers and pentamers (capsomers) that contain a central pore hypothesised to regulate capsid assembly and facilitate nucleotide import early during post-infection. These pore functions are mediated by
Alex Kleinpeter, Donna L. Mallery, Nadine Renner, Anna Albecka, J. Ole Klarhof, Eric O. Freed, Leo C. James   +6 more
doaj   +1 more source

Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus [PDF]

, 2011
Merkel cell polyomavirus (MCV) has been recently described as the cause for most human Merkel cell carcinomas. MCV is similar to simian virus 40 (SV40) and encodes a nuclear large T (LT) oncoprotein that is usually mutated to eliminate viral replication ...
Ali, Binda, Campbell, Campbell, Caplan, Cotsiki, Côté-Martin, DeCaprio, Dilworth, Felici, Feng, Flinn, Hakki, Houben, Jennifer Hein, Lane, Laude, Li, Liang, Linzer, Mannová, Nakamura, Nakamura, Ole V. Gjoerup, Pallas, Patrick S. Moore, Pelkmans, Per H. Basse, Peralta, Pipas, Poupon, Price, Qian, Richardson, Schowalter, Shuda, Shuda, Simon C.W. Richardson, Srinivasan, Sukarieh, Tuna Toptan, Whitman, Wrana, Wurmser, Xi Liu, Yuan Chang   +45 more
core   +2 more sources