Results 261 to 270 of about 754,819 (359)

Rational Design of Drugs That Induce Human Immunodeficiency Virus Replication

, 2003
Dean H. Hamer, Sven Bocklandt, Louise McHugh, Tae‐Wook Chun, Peter M. Blumberg, Dina M. Sigano, Víctor E. Márquez   +6 more
openalex   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket-Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target. [PDF]

Adv Sci (Weinh)
Ding X, Zeng D, Liu D, Bian Y, Li B, Li Z, Li Q, Liang S, Si Y, Yao Q, Ding Y, Zhu J, Li X, Zheng K, Guo H, Wang W.   +15 more
europepmc   +1 more source

The in vitro replication phenotype of hepatitis B virus (HBV) splice variants Sp3 and Sp9 and their impact on wild-type HBV replication

Laura C. McCoullough, Tomas Sadauskas, Vitina Sozzi, Kai Yan Mak, Hugh S. Mason, Margaret Littlejohn, Peter Revill   +6 more
openalex   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Long noncoding RNA HNF4A-AS1 upregulates TLE4 to inhibit hepatitis B virus replication. [PDF]

Virus Res
Liu L, Dai W, Wang Q, Qian H, Liu X, Hao Q.   +5 more
europepmc   +1 more source

RNA virus replication

Journal of Clinical Virology, 2000
openaire   +1 more source

Plant Virus‐Induced Inheritable Apoptosis Drives Reproductive Costs in Female Insect Vectors to Balance Viral Biparental Transmission

Advanced Science, EarlyView.
Rice gall dwarf virus (RGDV), transmitted biparentally by leafhopper vector to their offspring, exploits the capsid protein to induce inheritable ovarian apoptosis via insulin‐driven PI3K/AKT/FoxO signaling axis. This mechanism enhances infection but reduces female reproductive fitness, causing inefficient maternal transmission.
Haibo Wu, Wenqiang Wan, Qingquan Liang, Hengsong Yang, Chengcong Lu, Taiyun Wei, Qian Chen   +6 more
wiley   +1 more source

The interferon-inducible MxB large GTPase attenuates hepatitis B virus replication by activating the RIG-I innate immunity signaling pathway. [PDF]

Sci Rep
Onuki M, Inoue J, Doi K, Ninomiya M, Sano A, Tsuruoka M, Sato K, Sawahashi S, Ouchi K, Watanabe K, McNiven MA, Masamune A.   +11 more
europepmc   +1 more source