Results 271 to 280 of about 754,819 (359)

Interference of the Simian Virus 40 Origin of Replication by the Cytomegalovirus Immediate Early Gene Enhancer: Evidence for Competition of Active Regulatory Chromatin Conformation in a Single Domain

, 2000
Penghui Chen, Wen-Bin Tseng, Yi Chu, Ming‐Ta Hsu   +3 more
openalex   +2 more sources

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source

Human cytomegalovirus promotes <i>de novo</i> PC synthesis during early virus replication. [PDF]

J Virol
Kline I, Mokry RL, Xi Y, Passols Manzano M, Layesa S, Sohrab Ali N, Moy MA, Goodrum FD, Purdy JG.   +8 more
europepmc   +1 more source

Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection [PDF]

, 2018
et al,, Klein, Robyn S, Vollmer, Lauren L   +2 more
core   +1 more source

TREM2‐Mediated Cholesterol Efflux in Macrophages Inhibits Anti‐Tumor Immunity via Limitation of CD4+ T and NK Cells

Advanced Science, EarlyView.
Impaired anti‐tumor immunity is mediated by TREM2 + macrophages in non‐small cell lung cancer. TREM2 + macrophages prevent anti‐tumor immunity depending on the limitation of CD4 + T and NK cells. TREM2 promotes cholesterol efflux via ABCA1 to limit the production of CX3CL1 in macrophages.
Yunhan Wang, Weina Yu, Xinxin Wang, Qitai Zhao, Qingyang Lei, Aitian Li, Shasha Liu, Tian Wang, Li Yang, Yi Zhang   +9 more
wiley   +1 more source

Activation of IRE1 Endonuclease Activity Regulates Zika Virus Replication and Antiviral Response During Infection in Human Microglia. [PDF]

Viruses
Hernández-Díaz T, Oyarzún-Arrau A, Gaete-Argel A, López-Palma D, López-Schettini J, Fernández D, Valiente-Echeverría F, Osorio F, Soto-Rifo R.   +8 more
europepmc   +1 more source

140 Inhibition of AKT Kinase Activity Decreases Replication of Human Respiratory Syncytial Virus

, 2012
Kim C. Tran, Sandra Fuentes, Biao He, Michael N. Teng   +3 more
openalex   +1 more source

Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression

Advanced Science, EarlyView.
This study identifies SPTAN1‐kla as a novel oncogenic driver in HBV‐driven HCC, linking metabolic, epigenetic, and immune mechanisms. SPTAN1‐kla promotes HCC progression via NOTCH1/HES1 activation and immunosuppression. Findings highlight that targeting SPTAN1‐kla provides a framework for HCC treatment to improve clinical outcomes in HBV infected ...
Zengbin Wang, Dongjie Ye, Linqing Wu, Jiayu Liu, Banglun Pan, Zhu Zhang, Xiaoxia Zhang, Yuxin Yao, Nanhong Tang   +8 more
wiley   +1 more source

Heat shock protein 90 chaperone activity is required for hepatitis A virus replication. [PDF]

J Virol
Li Y, Zheng X, Xie L, Kapustina M, Shirasaki T, Yonish B, Chen X, Hirai-Yuki A, Nagata N, Suzuki R, Isogawa M, Vogt MR, Muramatsu M, Lemon SM.   +13 more
europepmc   +1 more source

Ultrastructural Characterization and Three-Dimensional Architecture of Replication Sites in Dengue Virus-Infected Mosquito Cells

, 2014
Jiraphan Junjhon, Janice Pennington, Thomas J. Edwards, Rushika Perera, Jason Lanman, Richard Kühn   +5 more
openalex   +2 more sources