Results 51 to 60 of about 760,800 (362)

Defined mutations in the 5' nontranslated sequence of Sindbis virus RNA [PDF]

, 1990
We have constructed 24 deletion mutants which contain deletions of from 1 to 15 nucleotides in the 5' nontranslated region of Sindbis virus RNA and tested the effect of these mutations on virus replication.
Niesters, Hubert G. M., Strauss, James H.   +1 more
core   +2 more sources

Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis [PDF]

, 2017
Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with ...
Amarasinghe, Gaya K, Basler, Christopher F, Batra, Jyoti, Leung, Daisy W, Luthra, Priya, Wu, Chao, Xu, Wei   +6 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Identification and characterization of a novel non-structural protein of bluetongue virus [PDF]

, 2011
Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue). For over two decades, it has been widely accepted that the 10 segments of the dsRNA genome of BTV encode for 7 structural and 3 non-structural proteins.
AA Van Dijk, AE Firth, AE Firth, AG Aminev, AG Aminev, AJ Wilson, Alessia Armezzani, Amr Bayoumy, Andrew Shaw, B Sherry, BJ Erasmus, C Gonzalez-Lopez, C Lee, C Vinson, CC Celma, CD DeMaula, CR Rinaldo Jr, D Grimm, E Calvo-Pinilla, E Calvo-Pinilla, E Matsuo, EL Nason, EW Rainsford, F Arnaud, FM Boisvert, Frazer Rixon, FW Bazer, G Sutton, G Van Heeke, Giulia Franzoni, I Schwartz-Cornil, JA Hiscox, JA Hiscox, JA Mertz, JM Grimes, JM Wehrfritz, Kathryn Allan, L Vazquez-Iglesias, LJ Reed, M Barro, M Boyce, M Boyce, M Caporale, M Caporale, M Marfori, M Mura, M Neville, M Palmarini, M Rojas, M Varela, MA Hofmann, Marco Caporale, Mark Heise, Massimo Palmarini, Matthew Golder, Maxime Ratinier, ME Peeples, MH Malim, MK Estes, MM Arnold, MR Michel, MR Yang, MS Lindstrom, N Feng, N Stauber, NJ Horscroft, NJ Maclachlan, NJ Maclachlan, NJ MacLachlan, NM Foster, P Franchi, P Gouet, P Jameson, P Roy, P Roy, PP Mertens, PP Mertens, PS Mellor, R Dulbecco, R Noad, R Volmer, RE Randall, RJ Owens, S Boulon, S Brandt, S Maan, S Maan, Sandro Filipe Nunes, SH Wang, SJ Wechsler, X Zhang, Z Han   +91 more
core   +12 more sources

Mycophenolic acid (MPA) modulates host cellular autophagy progression in sub genomic dengue virus-2 replicon cells [PDF]

, 2019
Cellular autophagy (Macrophagy) is a self-degradative process, executed through the network of autophagy associated genes (ATGs) encoded proteins. Both in vitro and in vivo studies suggest that dengue virus (DENV) induces autophagy and supports the viral
Dungdung, Ranjeet, Manchala, Nageswar Reddy, Pilankatta, Rajendra, Trivedi, Pankaj, Unniyampurath, Unnikrishnan   +4 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Discontinuous template switching generates coronavirus subgenomic RNAs from the 3ʹ viral genome end by 5ʹ to 3ʹ transcription

Journal of Virology
In coronavirus (CoV)-infected cells, several structural and accessory proteins are synthesized from subgenome RNAs (sgRNA) containing a common genomic 5ʹ-leader followed by a given open reading frame (ORF).
Ayslan Castro Brant, Zhe Hu, Angelika Zelma Chen, Vladimir Majerciak, Jonathan Yewdell, Zhi-Ming Zheng   +5 more
doaj   +1 more source

Autophagy induction regulates influenza virus replication in a time-dependent manner [PDF]

, 2017
Autophagy plays a key role in host defence responses against microbial infections by promoting degradation of pathogens and participating in acquired immunity.
Abdoli, Asghar, Bamdad, Taravat, Feizi, Amir, Feizi, Neda, Fotouhi, Fatemeh, Jamali, Abbas, Mehrbod, Parvaneh, Nasrollahi Nargesabad, Reza, Ollah Jazaeri, Ehsan, Romani, Bizhan, Saleh, Maryam, Shokouhi Targhi, Hadiseh, Soleimanjahi, Hoorieh   +12 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo

Retrovirology, 2019
Background Reverse transcription (RT) of HIV and SIV is initiated by the binding of the acceptor stem of tRNALys3 to the primer binding site (PBS) of the viral RNA genome.
Christine M. Fennessey, Celine Camus, Taina T. Immonen, Carolyn Reid, Frank Maldarelli, Jeffrey D. Lifson, Brandon F. Keele   +6 more
doaj   +1 more source