Passaging of a Newcastle disease virus pigeon variant in chickens results in selection of viruses with mutations in the polymerase complex enhancing virus replication and virulence [PDF]
, 2010 Some Newcastle disease virus (NDV) variants isolated from pigeons (pigeon paramyxovirus type 1; PPMV-1) do not show their full virulence potential for domestic chickens but may become virulent upon spread in these animals.
Peeters, B.P.H. +9 more
core +1 more source
, 2017 The replication processes used by individual viruses is highly variable. However, all viruses must attach to a susceptible host cell, enter the cell, disassemble the virus particle (uncoating), replicate its own genetic material and express the associated proteins, assemble new virus particles, and escape from the infected cell (release).
Burrell, Christopher J. +2 more
openaire +2 more sources
Role of Lipids in Virus Replication [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Viruses intricately interact with and modulate cellular membranes at several stages of their replication, but much less is known about the role of viral lipids compared to proteins and nucleic acids. All animal viruses have to cross membranes for cell entry and exit, which occurs by membrane fusion (in enveloped viruses), by transient local disruption ...
Maier, Lorizate, Hans-Georg, Kräusslich
openaire +2 more sources
Unravelling the structure of viral replication complexes at super-resolution [PDF]
, 2013 This work was supported by Biotechnology and Biomedical Sciences Research Council grant BB/H018719/1During infection, many RNA viruses produce characteristic inclusion bodies that contain both viral and host components.
Karl J. Oparka +12 more
core +1 more source
mBio, 2022 The relationship between spatiotemporal distribution of HIV-1 proviruses and their transcriptional activity is not well understood. To elucidate the intranuclear positions of transcriptionally active HIV-1 proviruses, we utilized an RNA fluorescence in ...
Ryan C. Burdick +5 more
doaj +1 more source
Glycyrrhizin exerts antioxidative effects in H5N1 influenza A virus-infected cells and inhibits virus replication and pro-inflammatory gene expression. [PDF]
, 2011 Glycyrrhizin is known to exert antiviral and anti-inflammatory effects. Here, the effects of an approved parenteral glycyrrhizin preparation (Stronger Neo-Minophafen C) were investigated on highly pathogenic influenza A H5N1 virus replication, H5N1 ...
Michaelis, Martin +20 more
core +1 more source
Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis [PDF]
, 2012 Conflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating the IFN-induction cascade are
Killip, M. J. +14 more
core +1 more source
Guanylate-binding protein 5 antagonizes viral glycoproteins independently of furin processing
mBioGuanylate-binding protein (GBP) 5 is an interferon-inducible cellular factor with broad anti-viral activity. Recently, GBP5 has been shown to antagonize the glycoproteins of a number of enveloped viruses, in part by disrupting the host enzyme furin. Here
Hana Veler +3 more
doaj +1 more source
Viruses, 2020 Combination antiretroviral therapy (cART) controls but does not eradicate HIV infection; HIV persistence is the principal obstacle to curing infections.
Elizabeth M. Anderson +15 more
doaj +1 more source
The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication [PDF]
, 2014 Most RNA viruses infecting mammals and other vertebrates show profound suppression of CpG and UpA dinucleotide frequencies. To investigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with altered CpG and UpA ...
Atkinson, N J +5 more
core +1 more source